Design and synthesis of a novel class of dual PPARγ/δ agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 4, 2007, Pages 1052-1055

  Gonzalez, Isabel C ^a   Lamar, Jason ^a   Iradier, Fatima ^a   Xu, Yanping ^a   Winneroski, Leonard L ^a   York, Jeremy ^a   Yumibe, Nathan ^a   Zink, Richard ^a   Montrose Rafizadeh, Chahrzad ^a   Etgen, Gary J ^a   Broderick, Carol L ^a   Oldham, Brian A ^a   Mantlo, Nathan ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Diabetes; Dyslipidemia; PPAR

Indexed keywords

3 [2 ETHYL 4 [3 (4 ETHYL 2 PYRIDIN 2 YLPHENOXY)BUTOXY]PHENYL]PROPIONIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROPIONIC ACID DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GLYCEMIC CONTROL; HYPERGLYCEMIA; IC 50; MALE; NONHUMAN; RAT; WEIGHT GAIN; ZUCKER DIABETIC FATTY RAT;

ANIMALS; BLOOD GLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FEMALE; HALF-LIFE; HUMANS; HYPOGLYCEMIC AGENTS; INDICATORS AND REAGENTS; INSULIN; MALE; PPAR DELTA; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES; WEIGHT GAIN;

RATTUS;

EID: 33846641605     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.029     Document Type: Article

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