Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 4, 2007, Pages 1047-1051

  Letavic, Michael A ^a   Keith, John M ^a   Jablonowski, Jill A ^a   Stocking, Emily M ^a   Gomez, Leslie A ^a   Ly, Kiev S ^a   Miller, Jennifer M ^a   Barbier, Ann J ^a   Bonaventure, Pascal ^a   Boggs, Jamin D ^a   Wilson, Sandy J ^a   Miller, Kirsten L ^a   Lord, Brian ^a   McAllister, Heather M ^a   Tognarelli, D J ^a   Wu, Jiejun ^a   Abad, Marta C ^a   Schubert, Carsten ^a   Lovenberg, Timothy W ^a   Carruthers, Nicholas I ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Histamine; Histamine H3 antagonists; Serotonin; Serotonin reuptake inhibitors; Tetrahydroisoquinolines

Indexed keywords

HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; TETRAHYDROISOQUINOLINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HALF-LIFE; HISTAMINE ANTAGONISTS; HUMANS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NOREPINEPHRINE; RATS; RECEPTORS, HISTAMINE H3; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 33846618166     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.036     Document Type: Article

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