Synthesis of a novel inhibitor against MRSA and VRE: Preparation from zerumbone ring opening material showing histidine-kinase inhibition

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 4, 2007, Pages 1098-1101

  Kitayama, Takashi ^a   Iwabuchi, Risa ^a   Minagawa, Shu ^a   Sawada, Seiji ^b   Okumura, Ryo ^c   Hoshino, Kazuki ^c   Cappiello, John ^d   Utsumi, Ryutaro ^a  

^a KINKI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY OF EDUCATION   (Japan)

^c DAIICHI SANKYO CO   (Japan)

^d ALLERGAN INC   (United States)

Author keywords

Drug resistant bacterium; Histidine kinase; Inhibitor; MRSA; Two component system; VRE; YycG; Zerumbone

Indexed keywords

ANTIBIOTIC AGENT; GINGER EXTRACT; PROTEIN HISTIDINE KINASE; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG; ZERUMBONE DERIVATIVE;

ARTICLE; AUTOPHOSPHORYLATION; BACILLUS SUBTILIS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RING OPENING; VANCOMYCIN RESISTANT ENTEROCOCCUS;

BACILLUS SUBTILIS; ENTEROCOCCUS FAECALIS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; PHOSPHORYLATION; PROTEIN KINASES; SESQUITERPENES; STAPHYLOCOCCUS AUREUS; TRYPTOPHAN;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 33846591804     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.015     Document Type: Article

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