Impact of Native, Recombinant, and Cross-Reactive Allergens on Humoral and T-Cell-Mediated Immune Responses

Immunology and Allergy Clinics of North America

Volumn 27, Issue 1, 2007, Pages 65-78

  Crameri, Reto ^a,b   Rhyner, Claudio ^a  

^a SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

^b UNIVERSITY OF SALZBURG   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CROSS REACTING ANTIGEN; CYCLOPHILIN; CYTOKINE; EPITOPE; MANGANESE SUPEROXIDE DISMUTASE; PHOSPHOLIPASE A2; PROFILIN; RECOMBINANT ANTIGEN; THIOREDOXIN;

ALLERGY; AMINO ACID SEQUENCE; ANTIGEN STRUCTURE; ASTHMA; ATOPY; B LYMPHOCYTE; CELLULAR IMMUNITY; CROSS REACTION; DIAGNOSTIC PROCEDURE; DRUG EFFECT; EFFECTOR CELL; HUMAN; HUMORAL IMMUNITY; IMMUNOMODULATION; IMMUNOTHERAPY; MOLECULAR BIOLOGY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; SENSITIZATION; STRUCTURE ANALYSIS; T LYMPHOCYTE;

ALLERGENS; ANTIBODY FORMATION; CROSS REACTIONS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNITY, CELLULAR; RECOMBINANT PROTEINS; T-LYMPHOCYTES;

EID: 33846570082     PISSN: 08898561     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.iac.2006.11.003     Document Type: Review

References (98)

1. Bachau V., and Durham S.R. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 24 5 (2004) 758-764
2. Sennhauser F.H., Braun-Fahrlander C., and Wildhaber J.H. The burden of asthma in children: a European perspective. Paediatr Respir Rev 6 1 (2005) 2-7
3. Kay A.B. Allergy and allergic diseases. First of two parts. N Engl J Med 344 1 (2001) 30-37
4. Kay A.B. Allergy and allergic diseases. Second of two parts. N Engl J Med 344 2 (2001) 109-113
5. Montanaro A., and Bardana Jr. E.J. The mechanisms, causes, and treatment of anaphylaxis. J Investig Allergol Clin Immunol 12 1 (2002) 2-11
6. Barnes P.J. Therapeutic strategies for allergic diseases. Nature 402 Suppl 6760 (1999) B31-B38
7. Strunk R.C., and Bloomberg G.R. Omalizumab for asthma. N Engl J Med 354 25 (2006) 2689-2695
8. Kankaanranta H., Lahdensuo A., Moilanen E., et al. Add-on therapy options in asthma not adequately controlled by inhaled corticosteroids: a comprehensive review. Respir Res 5 1 (2004) 17
9. Mascarell L., Van Overtvelt V., and Moingeon P. Novel ways for immune intervention in immunotherapy: mucosal allergy vaccines. Immunol Allergy Clin North Am 26 (2006) 283-306
10. Noon L. Prophylactic inoculation against hay fever. Lancet 1 (1911) 1572-1573
11. Müller U.R. Bee venom allergy in beekeepers and their family members. Curr Opin Allergy Clin Immunol 5 4 (2005) 343-347
12. Durham S.R., Walker S.M., Varga E.M., et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 341 7 (1999) 468-475
13. Thomas W.R., and Smith W. Towards defining the full spectrum of important house dust mite allergens. Clin Exp Allergy 29 12 (1999) 896-904
14. Crameri R., Limacher A., Weichel M., et al. Structural aspects and clinical relevance of Aspergillus fumigatus antigens/allergens. Med Mycol 44 (2006) S261-S267
15. Bohle B., and Vieths S. Improving diagnostic tests for food allergy with recombinant allergens. Methods 32 3 (2003) 292-299
16. van Ree R. The CREATE project: EU support for the improvement of allergen standardization in Europe. Allergy 59 6 (2004) 571-574
17. Vailes L., Sridhara S., Cromwell O., et al. Quantitation of the major fungal allergens, Alt a 1 and Asp f 1, in commercial allergenic products. J Allergy Clin Immunol 107 4 (2001) 641-646
18. Meinert R., Frischer T., Karmaus W., et al. Influence of skin prick test criteria on estimation of prevalence and incidence of allergic sensitization in children. Allergy 49 7 (1994) 526-532
19. Pastorello E.A., Incorvaia C., Ortolani C., et al. Studies on the relationship between the level of specific IgE antibodies and the clinical expression of allergy: I. Definition of levels distinguishing patients with symptomatic from patients with asymptomatic allergy to common aeroallergens. J Allergy Clin Immunol 96 5 (1995) 580-587
20. Dreborg S. The batch-to-batch variationof the potency of dog- and cat- allergen-coated lancets. Evaluation by skin prick testing. Allergy 48 5 (1993) 373-376
21. Platts-Mills T.A.E., and Chapman M.D. Allergen standardization. J Allergy Clin Immunol 87 (1991) 621-625
22. Muguerzat J., Capo C., Porri F., et al. Latex allergy: allergen identification in Hevea brasiliensis fractions by immunoblotting. Clin Exp Allergy 26 10 (1996) 1177-1181
23. Lewis S.A., Grimshaw K.E., Warner J.O., et al. The promiscuity of immunoglobulin E binding to peanut allergens, as determined by Western blotting, correlates with the severity of clinical symptoms. Clin Exp Allergy 35 6 (2005) 767-773
24. van Hage-Hamsten M., and Valenta R. Specific immunotherapy-the induction of new IgE-specificities?. Allergy 57 5 (2002) 375-378
25. Moverare R., Elfman L., Vesterinen E., et al. Development of new IgE specificities to allergic components in birch pollen extract during specific immunotherapy studied with immunoblotting and Pharmacia CAP System. Allergy 57 5 (2002) 423-430
26. Arruda L.K., Platts-Mills T.A., Fox J.W., et al. Aspergillus fumigatus allergen I, a major IgE-binding protein, is a member of the mitogillin family of cytotoxins. J Exp Med 172 5 (1990) 1529-1532
27. Di Felice G., Tinghino R., Federico R., et al. Use of monoclonal antibodies for the characterization of allergenic extracts. Ann Ist Super Sanita 27 1 (1991) 183-187
28. Chua K.Y., Stewart G.A., Thomas W.R., et al. Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases. J Exp Med 167 1 (1988) 175-182
29. Scheiner O. Recombinant allergens: biological, immunological and practical aspects. Int Arch Allergy Immunol 98 2 (1992) 93-96
30. Crameri R. Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications. Int Arch Allergy Immunol 115 (1998) 99-114
31. Chapman M.D., Smith A.M., Vailes L.D., et al. Recombinant allergens for diagnosis and therapy of allergic disease. J Allergy Clin Immunol 106 3 (2000) 409-418
32. Crameri R. High throughput screening: a rapid way to recombinant allergens. Allergy 56 Suppl 67 (2001) 30-34
33. Valenta R., and Kraft D. From allergen structure to new forms of allergen-specific immunotherapy. Curr Opin Immunol 14 4 (2002) 718-727
34. Wallner M., Gruber P., Radauer C., et al. La scale and medium scale production of recombinant allergens in Escherichia coli. Methods 32 3 (2004) 219-226
35. 2. Biochim Biophys Acta 1165 2 (1992) 201-210
36. 2 from honey bee venom is similar. J Allergy Clin Immunol 96 3 (1995) 395-402
37. 2 has the same potency to release histamine from basophils in patients with Hymenoptera allergy. J Allergy Clin Immunol 95 6 (1995) 1229-1235
38. 2. J Allergy Clin Immunol 94 1 (1994) 61-70
39. 2 does not affect the specific IgE, IgG4 and cytokine responses in bee sting allergy. Clin Exp Allergy 29 7 (1998) 839-849
40. 2. Clin Exp Allergy 27 8 (1997) 915-920
41. Hoffmann-Sommergruber K., O′Riordain G., Ahorn H., et al. Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1. Clin Exp Allergy 29 6 (1999) 840-847
42. Tresch S., Holzmann D., Baumann S., et al. In vitro and in vivo allergenicity of recombinant Bet v 1 compared to the reactivity of natural birch pollen extract. Clin Exp Allergy 33 8 (2003) 1153-1158
43. Schmid-Grendelmeier P., and Crameri R. Recombinant allergens for skin testing. Int Arch Allergy Immunol 125 2 (2001) 96-111
44. Schmid-Grendelmeier P., Holzmann D., Himly M., et al. Native Art v 1 and recombinant Art v 1 are able to induce humoral and T cell-mediated in vitro and in vivo responses in mugwort allergy. J Allergy Clin Immunol 111 6 (2003) 1328-1336
45. Crameri R., Lidholm J., Grönlund H., et al. Automated specific IgE assay with recombinant allergens: evaluation of the recombinant Aspergillus fumigatus allergen I in the Pharmacia CAP System. Clin Exp Allergy 26 12 (1996) 1411-1419
46. Hiller R., Laffer S., Harwanegg C., et al. Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J 16 (2002) 414-416
47. Allergome: a platform for allergen knowledge. Available at: www.allergome.org. Accessed December 28, 2006.
48. Heiss S., Mahler V., Steiner R., et al. Component-resolved diagnosis (CRD) of type I allergy with recombinant grass and tree pollen allergens by skin testing. J Invest Dermatol 113 5 (1999) 830-837
49. Valenta R., Lidholm J., Niederberger V., et al. The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT). Clin Exp Allergy 29 7 (1999) 896-904
50. Aalberse R.C., van der Gaag R., and van Leeuwen J. Serologic aspects of IgG4 antibodies. J Immunol 130 (1983) 722-726
51. Akdis C.A., Blesken T., Wymann D., et al. Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants. Eur J Immunol 28 3 (1998) 914-925
52. 2. J Immunol 91 (1993) 3582-3591
53. 2 in allergic patients. Eur J Immunol 25 (1995) 538-542
54. 2. Int Arch Allergy Immunol 117 (1998) 1-10
55. 2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol 101 (1998) 747-754
56. Flückiger S., Limacher A., Glaser A.G., et al. Structural aspects of cross-reactive allergens. Recent Research Developments in Allergy and Clinical Immunology 5 (2004) 57-75
57. Stadler M.B., and Stadler B.M. Allergenicity prediction by protein sequence. FASEB J 17 (2003) 1141-1143
58. Li K.B., Issac P., and Krishnan A. Predicting allergenic proteins using wavlet transform. Bioinformatics 20 (2004) 2572-2578
59. Valenta R., Duchene M., Ebner C., et al. Profilins constitute a novel family of functional plant pan-allergens. J Exp Med 175 (1992) 377-385
60. Reese G., Ayuso R., and Lehrer S.B. Tropomyosin: an invertebrate pan-allergen. Int Arch Allergy Immunol 119 (1999) 247-258
61. Barral P., Batanero E., Palomares O., et al. A major allergen from pollen defines a novel family of plant proteins and shows intra- and interspecies cross-reactivity. J Immunol 172 (2004) 3644-3651
62. Flückiger S., Fijten H., Whitley P., et al. Cyclophilins, a new family of cross-reactive allergens. Eur J Immunol 32 (2002) 10-17
63. Limacher A., Glaser A.G., Meier C., et al. Cross-reactivity and 1.4 Å crystal structure of Malassezia sympodialis Thioredoxin (Mala s 13), a member of a new pan-allergen family. J Immunol 178 (2007) 389-396
64. Ferreira F., Hirtenlehner K., Jelek A., et al. Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy. J Exp Med 183 (1996) 599-609
65. Valenta R., Sperr W.R., Ferreira F., et al. Induction of specific histamine release from basophils with purified natural and recombinant birch pollen allergens. J Allergy Clin Immunol 91 (1993) 88-97
66. Linhart B., and Valenta R. Molecular design of allergy vaccines. Curr Opin Immunol 17 (2005) 646-655
67. Hoffmann-Sommergruber K., Demoly P., Crameri R., et al. IgE reactivity to Api g 1, a major celery allergen, in a Central European population is based on primary sensitization to Bet v 1. J Allergy Clin Immunol 104 (1999) 478-484
68. May Y., Gadermaier G., Bohle B., et al. Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. Int Arch Allergy Immunol 139 (2006) 53-62
69. Bohle B., Radakovics A., Luttkopf D., et al. Characterization of the T cell response to the major hazelnut allergen, Cor a 1.04: evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens. Clin Exp Allergy 35 (2005) 1392-1399
70. Reuter A., Fortunato D., Garoffo L.P., et al. Novel isoforms of Pru av 1 with diverging immunoglobulin E binding properties identified by a synergistic combination of molecular biology and proteomics. Proteomics 5 (2005) 282-289
71. Breiteneder H., and Ebner C. Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol 1067 (2000) 27-36
72. Wagner S., Sowka S., Mayer C., et al. Identification of a Heave brasiliensis latex manganese superoxide dismutase (Hev b 10) as a cross-reactive allergen. Int Arch Allergy Immunol 125 (2001) 120-127
73. Andersson A., Rasool O., Schmidt M., et al. Cloning, expression and characterization of two new IgE-binding proteins from the yeast Malassezia sympodialis with sequence similarities to heat shock proteins and manganese superoxide dismutase. Eur J Biochem 271 (2004) 1885-1894
74. Radauer C., Willerroider M., Fuchs H., et al. Cross-reactive and species-specific immunoglobulin E epitopes of plant profilins: an experimental and structure-based analysis. Clin Exp Allergy 36 (2006) 920-929
75. Mellon M.B., Frank B.T., and Fang K.C. Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes. J Immunol 168 (2002) 290-297
76. Das Dores S., Chopin C., Romano A., et al. IgE-binding and cross-reactivity of a new 41 kDa allergen of codfish. Allergy 57 Suppl 72 (2002) 84-87
77. Bernard H., Negroni L., Chatel J.M., et al. Molecular basis of IgE cross-reactivity between human beta-casein and bovine beta-casein, a major allergen of milk. Mol Immunol 37 (2000) 161-167
78. Maynard F., Chatel J.M., and Wal J.M. Immunological IgE cross-reactions of bovine and human alpha-lactalbumins in cow's milk allergic patients. Food and Agricultural Immunology 11 (1999) 179-189
79. Baur X., Bossert J., and Koops F. IgE-mediated allergy to recombinant human insulin in a diabetic. Allergy 58 (2003) 676-678
80. Pandjaitan B., Swoboda I., Brandejsky-Pichler F., et al. Escherichia coli expression and purification of recombinant dog albumin, a cross-reactive animal allergen. J Allergy Clin Immunol 105 (2000) 279-285
81. Natter S., Seibeler S., Hufnagl P., et al. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. FASEB J 12 (1998) 1559-1569
82. Crameri R., Kodzius R., Konthur Z., et al. Tapping allergen repertoires by advanced cloning technologies. Int Arch Allergy Immunol 124 (2001) 43-47
83. Appenzeller U., Meyer C., Menz G., et al. IgE-mediated reactions to autoantigens in allergic diseases. Int Arch Allergy Immunol 118 (1999) 193-196
84. Mayer C., Hemmann S., Faith A., et al. Cloning, production, characterization and IgE cross-reactivity of different manganese superoxide dismutases in individuals sensitized to Aspergillus fumigatus. Int Arch Allergy Immunol 113 (1997) 213-215
85. Crameri R., Faith A., Hemmann S., et al. Humoral and cell-mediated autoimmunity in allergy to Aspergillus fumigatus. J Exp Med 184 (1996) 265-270
86. Flückiger S., Scapozza L., Mayer C., et al. Immunological and structural analysis of IgE-mediated cross-reactivity between manganese superoxide dismutases. Int Arch Allergy Immunol 128 (2002) 292-303
87. Flückiger S., Mittl P.R.E., Scapozza L., et al. Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2 Å resolution. J Immunol 168 (2002) 1267-1272
88. Schmid-Grendelmeier P., Flückiger S., Disch R., et al. IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol 115 (2005) 1068-1075
89. Schmid-Grendelmeier P., Scheynius A., and Crameri R. The role of sensitization to Malassezia sympodialis in atopic eczema. Chem Immunol Allergy 91 (2006) 98-109
90. 2 protein. J Exp Med 189 (1999) 1507-1512
91. Limacher A., Kloer D.P., Flückiger S., et al. The crystal structure of Aspergillus fumigatus cyclophilin reveals 3D domain swapping of a central element. Structure 14 (2006) 185-195
92. Glaser A.G., Limacher A., Flückiger S., et al. Analysis of the cross-reactivity and of the 1.5 Å crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family. Biochem J 396 (2006) 41-49
93. Weichel M., Vergoossen N.J., Bonomi S., et al. Screening the allergenic repertoires of wheat and maize with sera from double-blind, placebo-controlled food challenge positive patients. Allergy 61 (2006) 128-135
94. Weichel M., Glaser A.G., Ballmer-Weber B.K., et al. Wheat and maize thioredoxins: a novel cross-reactive cereal allergen family related to baker's asthma. J Allergy Clin Immunol 117 (2006) 676-681
95. Neudecker P., Lehmann K., Nerkamp J., et al. Mutational epitope analysis of Pru av 1 and Api g 1, the major allergens of cherry (Prunus avium) celery (Apium graveolens): correlating IgE reactivity with three-dimensional structure. Biochem J 376 (2003) 97-107
96. Crameri R. Correlating IgE reactivity with three-dimensional structure. Biochem J 276 (2003) e1-e2
97. Valenta R., Seiberler S., Natter S., et al. Autoallergy: a pathogenetic factor in atopic dermatitis?. J Allergy Clin Immunol 105 (2000) 432-437
98. Aalberse R.C. Structural biology of allergens. J Allergy Clin Immunol 106 (2000) 228-238