Calcium modulation of monoclonal antibody binding to phosphatidylinositol phosphate

Biochemical and Biophysical Research Communications

Volumn 354, Issue 3, 2007, Pages 747-751

  Beck, Zoltan ^a   Karasavvas, Nicos ^b   Tong, James ^b   Matyas, Gary R ^b   Rao, Mangala ^b   Alving, Carl R ^b  

^a Henry M Jackson Foundation for Military Medical Research   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

4E10; Antibodies to phospholipids; Calcium; HIV 1; Liposomes; Monoclonal antibodies; Phosphatidylinositol phosphate; Phosphoinositide; Surface plasmon resonance

Indexed keywords

CALCIUM ION; HAPTEN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LIPOSOME; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4E10; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHOLIPID; POLYPHOSPHOINOSITIDE; VIRUS ENVELOPE PROTEIN;

ARTICLE; BINDING AFFINITY; BIOCHIP; ENZYME LINKED IMMUNOSORBENT ASSAY; MODULATION; PHOSPHORYLATION; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; CALCIUM; CATIONS, DIVALENT; DOSE-RESPONSE RELATIONSHIP, DRUG; EDETIC ACID; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV-1; HUMANS; HYDROPHOBICITY; IMMUNOGLOBULIN M; LIPOSOMES; MICE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOLIPIDS; VIRAL ENVELOPE PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS 1; MURINAE;

EID: 33846569482     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.01.033     Document Type: Article

References (16)

1. Kabat E.A. The antibody combining site. Prog. Immunol. 5 (1983) 67-85
2. Kabat E.A., Kiao J., Sherman W.H., and Osserman E.F. Immunochemical characterization of the specificities of two human monoclonal IgM's reacting with chondroitin sulfates. Carbohydr. Res. 130 (1984) 289-297
3. Wassef N.M., Roerdink F., Swartz G.M., Lyon J.A., Berson B.J., and Alving C.R. Phosphate-binding specificity of monoclonal antibodies to phosphoinositides in liposomes. Mol. Immunol. 21 (1984) 863-868
4. Alving C.R. Antibodies to liposomes, phospholipids, and phosphate esters. Chem. Phys. Lipids 40 (1986) 303-314
5. Hauser H., and Dawson R.M.C. The displacement of calcium ions from phospholipid monolayers by pharmacologically active and other organic bases. Biochem. J. 109 (1968) 909-916
6. Macdonald P.M., and Seelig J. Calcium binding to mixed phosphatidylglycerol-phosphatidylcholine bilayers as studied by deuterium nuclear magnetic resonance. Biochemistry 26 (1987) 1231-1240
7. Alving B.M., Banerji B., Fogler W.E., and Alving C.R. Lupus anticoagulant activities of murine monoclonal antibodies to liposomal phosphatidylinositol phosphate. Clin. Exp. Immunol. 69 (1987) 403-408
8. Haynes B.F., Fleming J., St Clair E.W., Katinger H., Stiegler G., Kunert R., Robinson J., Scearce R.M., Plonk K., Staats H.F., Ortel T.L., Liao H.X., and Alam S.M. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science 308 (2005) 906-1908
9. Sanchez-Martinez S., Lorizate M., Katinger H., Kunert R., and Nieva J.L. Membrane association and epitope recognition by HIV-1 neutralizing anti-gp41 2F5 and 4E10 antibodies. AIDS Res. Hum. Retroviruses 22 (2006) 998-1006
10. Brown B.K., Karasavva N., Beck Z., Matyas G.R., Birx D.L., Polonis V.R., and Alving C.R. Monoclonal antibodies to phosphatidylinositol phosphate neutralize HIV-1: role of phosphate binding subsites. J. Virol. 81 4 (2007) 2087-2091
11. Wassef N.W., Alving C.R., and Richards R.L. Liposomes as carriers for vaccines. Immunomethods 4 (1994) 217-222
12. Green F.A., and Costello P.B. Divalent cation effects on the binding of human anti-phospholipid antibodies. Biochim. Biophys. Acta 896 (1987) 47-51
13. Zhou T., Hamer D.H., Hendrickson W.A., Sattentau Q.J., and Kwong P.D. Interfacial metal and antibody recognition. Proc. Natl. Acad. Sci. USA 102 (2005) 14575-14580
14. Alving C.R., Beck Z., Karasavva N., Matyas G.R., and Rao M. HIV-1, lipid rafts, and antibodies to liposomes. Implications for viral-neutralizing antibodies (review). Mol. Memb. Biol. 23 6 (2006) 453-465
15. Williamson P., Christie A., Kohlin T., Schlegel R.A., Comfurius P., Harmsma M., Zwaal R.F., and Bevers E.M. Phospholipid scramblase activation pathways in lymphocytes. Biochemistry 40 (2001) 8065-8072
16. Sims P.J., and Wiedmer T. Unraveling the mysteries of phospholipid scrambling. Thromb. Haemost. 86 (2001) 266-275