Impaired extracellular matrix degradation in aortic vessels of cirrhotic rats

Journal of Hepatology

Volumn 46, Issue 3, 2007, Pages 440-446

  Fernández Varo, Guillermo ^a   Morales Ruiz, Manuel ^a   Ros, Josefa ^a   Tugues, Sònia ^a   Muñoz Luque, Javier ^a   Casals, Gregori ^a   Arroyo, Vicente ^a   Rodés, Juan ^a   Jiménez, Wladimiro ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

Aortic vessels; Extracellular matrix (ECM); Matrix metalloproteinases (MMPs); Mitogen activated protein kinases (MAPKs); Nitric oxide (NO)

Indexed keywords

COLLAGEN TYPE 4; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N(G) NITROARGININE METHYL ESTER; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CELL GROWTH; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; LIVER CIRRHOSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; THICKNESS; VASCULAR DISEASE;

ANIMALS; AORTA; APOPTOSIS; CARBON TETRACHLORIDE; COLLAGEN TYPE IV; EXTRACELLULAR MATRIX; LIVER; LIVER CIRRHOSIS; MALE; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE SYNTHASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 33846565842     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2006.09.023     Document Type: Article

References (26)

1. Fernández-Varo G., Ros J., Morales-Ruiz M., Cejudo-Martín P., Arroyo V., Solé M., et al. Nitric oxide synthase 3-dependent vascular remodeling and circulatory dysfunction in cirrhosis. Am J Pathol 162 (2003) 1985-1993
2. Mii S., Khalil R.A., Morgan K.G., Ware J.A., and Kent K.G. Mitogen-activated protein kinase and proliferation of human vascular smooth muscle cells. Am J Physiol 270 (1996) H142-H150
3. Force T., and Bonventre J.V. Growth factors and mitogen-activated protein kinases. Hypertension 31 (1998) 152-161
4. Touyz R.M., and Schiffrin E.L. AngII-stimulated generation of reactive oxygen species in human vascular smooth muscle cells is mediated via PLD-dependent pathways. Hypertension 34 (1999) 976-982
5. Touyz R.M., He G., Deng L.Y., and Schiffrin E.L. Role of extracellular signal-regulated kinases in angiotensin II-stimulated contraction of smooth muscle cells from human resistance vessels. Circulation 99 (1999) 392-399
6. Robinson M.J., and Cobb M.H. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9 (1997) 180-186
7. Morinville A., Maysinger D., and Shaver A. From vanadis to atorpos: vanadium compounds as pharmacological tools in cell death signaling. Trends Pharmacol Sci 19 (1998) 452-459
8. New L., and Han J. The p38 MAP Kinase pathway and its biological function. Trends Cardiovasc Med 8 (1998) 220-229
9. Wang Y., Huang S., Sah V.P., Ross Jr. J., Brown J.H., Han J., et al. Cardiac muscle hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem 273 (1998) 2161-2168
10. Gratton J.P., Morales-Ruiz M., Kureishi Y., Fulton D., Walsh K., and Sessa W.C. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J Biol Chem 276 (2001) 30359-30365
11. Lafont A., Durand E., Samuel J.L., Besse B., Addad F., Levy B.I., et al. Endothelial dysfunction and collagen accumulation: two independent factors for restenosis and constrictive remodeling after experimental angioplasty. Circulation 100 (1999) 1109-1115
12. Kuzuya M., and Iguchi A. Role of matrix metalloproteinases in vascular remodeling. J Atheroscler Thromb 10 (2003) 275-282
13. Zempo N., Koyama N., Kenagy R.D., Lea H.J., and Clowes A.W. Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor. Arterioscler Thromb Vasc Biol 16 (1996) 28-33
14. Cheng L., Mantile G., Pauly R., Nater C., Felici A., Monticone R., et al. Adenovirus-mediated gene transfer of the human tissue inhibitor of metalloproteinase-2 blocks vascular smooth muscle cell invasiveness in vitro and modulates neointimal development in vitro. Circulation 98 (1998) 2195-2201
15. Eagleton M.J., Peterson D.A., Sullivan V.V., Roelofs K.J., Ford J.A., Stanley J.C., et al. Nitric oxide inhibition increases aortic wall matrix metalloproteinase-9 expression. J Surg Res 104 (2002) 15-21
16. Clària J., and Jiménez W. Renal dysfunction and ascites in carbon-tetrachloride-induced cirrhosis in rats. In: Arroyo V., Ginès P., Rodés J., and Schrier R.W. (Eds). Ascites and Rrenal Disfunction in Liver Disease. Pathogenesis Diagnosis and Treatment (1999), Blackwell Science Inc, Malden, MA 379-396
17. Gavrieli Y., Sherman Y., and Ben Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119 (1992) 493-501
18. Yu S.M., Hung L.M., and Lin C.C. cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signalling pathway. Circulation 95 (1997) 1269-1277
19. Mitani Y., Zaidi S.H.E., Dufourcq P., Thompson K., and Rabinovitch M. Nitric oxide reduces vascular smooth muscle cell elastase activity through cGMP-mediated suppression of ERK phosphorylation and AML1B nuclear partitioning. FASEB J 14 (2000) 805-814
20. Mulvany M.J. Small artery remodeling and significance in the development of hypertension. News Physiol 17 (2002) 105-109
21. Longo G.M., Xiong W., Greiner T.C., Zhao Y., Fiotti N., and Baxter B.T. Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J Clin Invest 110 (2002) 625-632
22. Gurjar M.V., Sharma R.V., and Bhalla R.C. eNOS gene transfer inhibits smooth muscle cell migration and MMP-2 and MMP-9 activity. Arterioscler Tromb Vasc Biol 19 (1999) 2871-2877
23. Garanich J.S., Pahakis M., and Tarbell J.M. Shear stress inhibits smooth muscle cell migration via nitric oxide-mediated downregulation of matrix metalloproteinase-2 activity. Am J Physiol 288 (2005) H2244-H2252
24. Matsunaga T., Weihrauch D.W., Moniz M.C., Tessmer J., Warltier D.C., and Chilian W.M. Angiostatin inhibits coronary angiogenesis during impaired production of nitric oxide. Circulation 105 (2002) 2185-2191
25. Wang W., Viappiani S., Sawicka J., and Schulz R. Inhibition of endogenous nitric oxide in the heart enhances matrix metalloproteinase-2 release. Brit J Pharmacol 145 (2005) 43-49
26. Domenicalli M., Ros J., Fernandez-Varo G., Cejudo-Martin P., Crespo M., Morales-Ruiz M., et al. Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors. Gut 54 (2005) 522-527