Nitric oxide synthase 3-dependent vascular remodeling and circulatory dysfunction in cirrhosis

American Journal of Pathology

Volumn 162, Issue 6, 2003, Pages 1985-1993

  Fernández Varo, Guillermo ^a   Ros, Josefa ^a   Morales Ruiz, Manuel ^a   Cejudo Martín, Pilar ^a   Arroyo, Vicente ^a   Solé, Manel ^a   Rivera, Francisca ^a   Rodés, Juan ^a   Jiménez, Wladimiro ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY COMPLIANCE; ARTICLE; ASCITES; BLOOD VESSEL DIAMETER; BLOOD VESSEL WALL; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; HEMODYNAMICS; HISTOLOGY; LIVER CIRRHOSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASCULAR RESISTANCE;

EID: 0037568328     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64331-3     Document Type: Article

References (27)

1. Gibbons GH, Dzau VJ: The emerging concept of vascular remodeling. N Engl J Med 1994, 330:1431-1438
2. Mulvany MJ: Vascular remodeling of resistance vessels: can we define this? Cardiovasc Res 1999, 41:9-13
3. Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC: Direct evidence of the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest 1998, 101:731-736
4. Dzau VJ, Horiuchi M: Vascular remodeling: the emerging paradigm of programmed cell death (apoptosis). Chest 1998, 114:91S-99S
5. Arroyo V, Jimenez W: Renal and circulatory dysfunction in cirrhosis. Lights and shadows in an important clinical problem. J Hepatol 2000, 32(Suppl 1):157-170
6. Arroyo V, Ginés P, Jiménez W, Rodés J: Renal dysfunction in cirrhosis. Oxford Textbook of Clinical Hepatology, ed 2 Edited by J Bircher, JP Benhamou, N McIntyre, M Rizzetto, J Rodés. Oxford, Oxford Medical Publications, 1999, pp 733-761
7. Morales M, Jiménez W, Pérez-Sala D, Ros J, Leivas A, Lamas S, Rivera F, Arroyo V: Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites. Hepatology 1996, 24: 1481-1486
8. Clària J, Jiménez W: Renal dysfunction and ascites in carbon-tetra-chloride-induced cirrhosis in rats. Ascites and renal dysfunction in liver disease. Pathogenesis Diagnosis and Treatment. Edited by V Arroyo, P Ginès, J Rodés, RW Schrier. Malden, MA, Blackwell Science Inc., 1999, pp 379-396
9. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with folin phenol reagent. J Biol Chem 1951, 193:265-275
10. Zhao H, Shimokaw H, Uragami-Harasawa L, Igarashi H, Takeshita A: Long-term vascular effects of Nω-nitro-L-arginine methyl ester are not solely mediated by inhibition of endothelial nitric oxide synthesis in the rat mesenteric artery. J Cardiovasc Pharmacol 1999, 33:554-566
11. Niederberger M, Martin PY, Ginés P, Morris K, Tsai P, Xu DL, McMurtry J, Schrier RW: Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats Gastroenterology 1995, 109:1624-1630
12. Cornwell TL, Arnold E, Boerth NJ, Lincoln TM: Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am J Physiol 1994, 267:C1405-C1413
13. von der Leyen HE, Gibbons GH, Morishita R, Lewis NP, Zhang L, Nakajima M, Kaneda Y, Cooke JP, Dzau VJ: Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci USA 1995, 92:1137-1141
14. Sarkar R, Meinberg EG, Stanley JC, Gordon D, Webb RC: Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Circ Res 1996, 78:225-230
15. Murrell GA, Jang D, Williams RJ: Nitric oxide activates metalloprotease enzymes in articular cartilage. Biochem Biophys Res Commun 1995, 206:15-21
16. Castro A, Jiménez W, Clària J, Ros J, Martinez JM, Bosch M, Arroyo V, Piulats J, Rivera F, Rodés J: Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide. Hepatology 1993, 18:367-372
17. Clària J, Jiménez W, Ros J, Rigol M, Angeli P, Arroyo V, Rivera F, Rodés J: Increased nitric oxide dependent vasorelaxation in aortic rings of cirrhotic rats with ascites. Hepatology 1994, 20:1615-1621
18. Ros J, Jiménez W, Lamas S, Clària J, Arroyo V, Rivera F, Rodés J: Nitric oxide production in arterial vessels of cirrhotic rats. Hepatology 1995, 21:554-560
19. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999, 399:597-601
20. McCabe TJ, Fulton D, Roman LT, Sessa WC: Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation. J Biol Chem 2000, 275: 6123-6128
21. Sarkar R, Gordon D, Stanley JC, Webb RC: Cell cycle effect of nitric oxide on vascular smooth muscle cells. Am J Physiol 1997, 272: H1810-H1818
22. Guo K, Andrés V, Walsh K: Nitric oxide-induced down regulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Circulation 1998, 97:2066-2072
23. Mancini GB, Henry GC, Macaya C, O'Neill BJ, Pucillo AL, Carere RG, Wargovich TJ, Mudra H, Luscher TF, Klibaner MI, Haber HE, Uprichard AC, Pepine CJ, Pitt B: Angiotensin converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing Endothelial Dysfunction). Circulation 1996, 94:258-265
24. Treasure CB, Klein JL, Weintraub WS, Talley JD, Stillabower ME, Kosinski AS, Zhang J, Boccuzzi SJ, Cedarholm JC, Alexander RW: Beneficial effects of cholesterol lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 1995, 332:481-487
25. Safar M, Simon A, Leverson J: The arterial wall: relationships between haemodynamic and structural aspects in man. Diseases of the Arterial Wall. Edited by JP Camilleri, CL Berry, JN Fiessinger, J Bariety. Berlin, Springer-Verlag, 1989, pp 269-278
26. Numaguchi K, Egashira K, Takemoto M, Kadokami T, Shimokawa H, Sueishi K, Takeshita A: Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats. Hypertension 1995, 26:957-962
27. Rossi MA. Colombini-Netto M: Chronic inhibition of NO synthesis per se promotes structural intimal remodeling of the rat aorta. J Hypertens 2001, 19:1567-1579