Why are clinical trials in pediatric head injury so difficult?

Pediatric Critical Care Medicine

Volumn 8, Issue 1, 2007, Pages 71-

  Duhaime, Ann Christine ^a  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAGNESIUM SULFATE;

CHILD CARE; CHILD DEVELOPMENT; CHILDHOOD INJURY; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG SAFETY; EDITORIAL; EVIDENCE BASED MEDICINE; HEAD INJURY; HUMAN; MATURATION; MEDICAL LITERATURE; MEDICAL RESEARCH; NEUROPROTECTION; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PUBLICATION;

AGE FACTORS; ANIMALS; BRAIN INJURIES; CHILD; CLINICAL TRIALS; CRANIOCEREBRAL TRAUMA; DISEASE MODELS, ANIMAL; FEASIBILITY STUDIES; HUMANS; MAGNESIUM SULFATE; NEUROPROTECTIVE AGENTS; PILOT PROJECTS; RODENTIA;

EID: 33846534137     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.PCC.0000253552.60687.AC     Document Type: Editorial

References (5)

1. Natale JE, Guerguerian AM, Joseph JG, et al: Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury. Pediatr Crit Care Med 2007; 8:1-9
2. Narayan RK, Michel ME, Ansell B, et al: Clinical trials in head injury. J Neurotrauma 2002; 19:503-557
3. Natale JE, Joseph JG, Pretzlaff R, et al: Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses. Dev Neurosci 2006; 28:276-290
4. Robertson CL, McKenna MC: Preface. Dev Neurosci 2006; 28:243
5. Kochanek PM: Pediatric traumatic brain injury: Quo vadis? Dev Neurosci 2006; 28:244-255