Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice

International Journal of Developmental Neuroscience

Volumn 25, Issue 1, 2007, Pages 23-28

  Saeed, O ^a   Yaghmaie, F ^b   Garan, S A ^c   Gouw, A M ^e   Voelker, M A ^d   Sternberg, H ^d   Timiras, P S ^e  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c Aging Research Centre   (Canada)

^d BIOTIME INC   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Caloric restriction; Hypothalamus; IGF 1; IGF 1 receptor; IGF 1R; Paraventricular nucleus; Six week old young mice; Twenty two month old mice

Indexed keywords

SOMATOMEDIN B RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; CALORIC RESTRICTION; CELL AGING; CELL COUNT; CELL LOSS; CELL POPULATION; FEMALE; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; MICROSCOPE IMAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; THALAMUS MIDLINE NUCLEUS;

AGE FACTORS; ANIMALS; CALORIC RESTRICTION; CELL COUNT; FEMALE; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MICE; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RECEPTOR, IGF TYPE 1;

MAMMALIA; MUS;

EID: 33846531764     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2006.11.004     Document Type: Article

References (24)

1. Aberg N.D., Brywe K.G., and Isgaard J. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. Sci. World J. 18 6 (2006) 53-80
2. Bartke A., and Brown-Borg H. Life extension in the dwarf mouse. Curr. Top. Dev. Biol. 63 (2004) 189-225
3. Bartke A., Masterneck M.M., Al-Regaiey K.A., and Bonkowski M.S. Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice. Interdiscipl. Top Gerontol. 35 (2007) 69-82
4. Breese C.R., Ingram R.L., and Sonntag W.E. Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. J. Gerontol. 46 5 (1991) B180-B187
5. Bluher M., Hahn B.B., and Khan C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 (2003) 572-574
6. Clancy D.J., Gems D., Harshman L.G., Oldham S., Stocker H., Hafen E., Leevers S.J., and Partridge L. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292 5514 (2001) 104-106
7. Garan S.A., Neudorf J., Tonkin J., McCook L.R., and Timiras P.S. Creating three-dimensional maps of the mouse hypothalamus using an automated imaging microscope system. Exp. Gerontol. 35 (2000) 1421
8. Hasty P., Campisi J., Hoeijmakers J., van Steeg H., and Vijg J. Aging and genome maintenance: lessons from the mouse?. Science 299 (2003) 1355-1359
9. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., Even P., Cervera P., and Le Bouc P. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421 (2003) 182-187
10. Kandel R.E., Schwartz J.H., and Thomas M. Principles of Neural Science (2000), McGraw Hill Companies Inc., USA
11. Kenyon C., Chang J., Gensch E., Rudner A., and Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 336 (1993) 461-464
12. Lopez T., and Hanahan D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 1 (2002) 339-353
13. Mobbs C.V., Bray G.A., Atkinson R.L., Bartke A., Finch C.E., Maratos-Flier E., Crawley J.N., and Nelson J.F. Neuroendocrine and pharmacological manipulation to assess how caloric restriction increases lifespan. J. Gerontol. A: Biol. Sci. Med. Sci. 56 (2001) 34-44
14. Mynarcik D.C., Williams P.F., Schaffer L., Yu G.Q., and Whittaker J. Identification of common ligand binding determinants of the insulin and insulin like growth factor 1 receptors: insights into mechanisms of ligand binding. J. Biol. Chem. 272 (1997) 18650-18655
15. Paxinos G., and Franklin K. The Mouse Brain in Stereotaxic Coordinates. 2nd ed. (2001), Academic Press, Hong Kong
16. Ramsey J.J., Harper M.E., and Weindruch R. Restriction of energy intake, energy expenditure, and aging. Free Radic. Biol. Med. 29 10 (2000) 946-968
17. Sohal R.S., and Weindruch R. Oxidative stress, caloric restriction, and aging. Science 273 (1996) 59-63
18. Tatar M., Bartke A., and Antebi A. The endocrine regulation of aging by insulin-like signals. Science 299 (2003) 1346-1351
19. Trejo J.L., Carro E., Garcia-Galloway E., and Torres-Aleman I. Role of insulin-like growth factor I signaling in neurodegenerative diseases. J. Mol. Med. 82 3 (2004) 156-162
20. Turturro A., Witt W.W., Lewis S., Hass B.S., Lipman R.D., and Hart R.W. Growth curves and survival characteristics of the animals used in the biomarkers of aging program. Gerontology A 54 (1999) B492-B501
21. Weindruch R., and Walford R.L. The Retardation of Aging and Disease by Dietary Restriction (1988), Charles C. Thomas, Springfield, IL
22. Yaghmaie F., Saeed O., Garan S.A., Freitag W., Timiras P.S., and Sternberg H. Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice. Neuroendocrinol. Lett. 26 3 (2005 Jun) 197-203
23. Yaghmaie F., Saeed O., Garan S.A., Voelker M., Gouw A., Freitag W., Sternberg H., and Timiras P.S. Age-dependent loss of Insulin-like growth factor-1 receptor immunoreactive cells in the Supraoptic hypothalamus is reduced in calorically restricted mice. Int. J. Dev. Neurosci. 24 7 (2006) 431-436
24. Zhou X., Herman J.P., and Paden C.M. Evidence that IGF-1 acts as an autocrine/paracrine growth factor in the magnocellular neurosecretory system: neuronal synthesis and induction of axonal sprouting. Exp. Neurol. 159 2 (1999 Oct) 419-432