Reduced acetylcholinesterase activity in erythrocyte membranes from patients with phenylketonuria

Clinical Biochemistry

Volumn 35, Issue 8, 2002, Pages 615-619

  Tsakiris, Stylianos ^a   Schulpis, Kleopatra H ^b   Tjamouranis, Joanna ^b   Michelakakis, Helen ^b   Karikas, George A ^b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

Author keywords

AChE activity; Alanine; Dopamine; Phenylalanine; PKU; Tyrosine

Indexed keywords

ACETYLCHOLINESTERASE; ALANINE; DOPAMINE; PHENYLALANINE; TYROSINE;

AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; DOPAMINE BLOOD LEVEL; ENZYME ACTIVITY; ERYTHROCYTE MEMBRANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INCUBATION TIME; PHENYLKETONURIA; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SPECTROPHOTOMETRY;

ACETYLCHOLINESTERASE; AMINO ACIDS; CELL MEMBRANE; CHILD; DOPAMINE; ERYTHROCYTES; HUMANS; PHENYLKETONURIAS;

EID: 0036867140     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9120(02)00381-8     Document Type: Article

References (25)

1. Antonas K.N., Coulson W.F. Brain uptake and protein incorporation of amino acids studied in rats subjected to prolonged hyperphenylalaninemia. J Neurochem. 25:1975;309-314.
2. Burri R., Stefen C., Stiger S., Brodbeck U., Colombo J.P., Herschkowitz N. Reduced myelinogenesis and recovery in hyperphenylalaninemic rats. Correlation between brain phenylalanine levels, characteristic brain enzymes for myelination and brain development. Mol Chem Neuropathol. 13:1990;57-69.
3. Candito M., Albertini M., Politano S., Deville A., Mariani R. Plasma catecholamine in children. J Chromatograph. 617:1993;304-307.
4. Carlson H., Hyman D., Blitzer M. Evidence for an intracerebral action of phenylalanine in stimulation of prolactin secretion. J Clin Endocr Metab. 70:1990;814-819.
5. Curtius H., Wiederwieser C., Viscontini G., Leimbacher N., Wegman H., Schmidt H. Serotonin and dopamine synthesis in phenylketonuria. Adv Exp Med Biol. 133:1981;277-291.
6. +-ATPase activities in suckling rat frontal cortex, hippocampus and hypothalamus. Z Naturforsch. 57c:2002;182-188.
7. Ellman GL, Courtney D, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961;7:88-5.
8. Fernstrom J.D. Dietary amino acids and brain function. J Am Diet Assoc. 94:1994;71-77.
9. th ed. Oxford: Blackwell Scientific Publ.; 1989. p. 224-55.
10. Galbraith D.A., Watts D.C. Changes in some cytoplasmic enzymes from red cells fractionated into age groups by centrifugation in Ficoll/Triosil gradients. Biochem J. 191:1980;63-70.
11. Hawkinks D.A., Greenfield S.A. Non-cholinergic action of exogenous acetylcholinesterase in the rat substantia nigra. II. Long-term interactions with dopamine metabolism. Behav Brain Res. 48:1992;159-163.
12. Huges J.V., Johnson T.C. The effect of hyperphenylalaninemia on the concentration of amino acyltransferribonucleic acid in vivo. Biochem J. 162:1977;527-537.
13. Kamber E., Poyiagi A., Deliconstantinos G. Modifications in the activities of membrane-bound enzymes during in vivo ageing of human and rabbit erythrocytes. Comp Biochem Physiol. 77B:1984;95-99.
14. Krause W., Halminski M., McDonald L. Biochemical and neuropsychological effects of elevated plasma phenylalanine in patients with phenylketonuria. J Clin Invest. 15:1985;40-48.
15. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem. 193:1951;265-275.
16. Missiou-Tsagaraki S., Soulpi K., Loumakou M. Phenylketonuria in Greece, 12 years experience. J Mental Def Res. 32:1988;271-281.
17. Ohno M., Kobayashi M., Kishi A., Watanabe S. Working memory failure by combined blockade of cholinergic and β-adrenergic transmission in the rat hippocampus. Neuroreport. 8:1997;1571-1575.
18. Schulpis K.H., Papakonstantinou E., Michelakakis H. Elevated serum prolactin concentrations in phenylketonuric patients on a "loose diet" Clin Endocrinol. 48:1998;99-101.
19. Scriver C., Kaufman S., Eisensmith R., Woo S. The hyperphenylalaninemias. Scriver C., Beadet A., Sly W., Valle D. The metabolic and molecular bases of inherited disease. 2000;1667-1725 McGraw Hill, New York, NY.
20. Taub F., Johnson T.C. The mechanism of polyribosomes? Some disaggregation in brain tissue by phenylalanine. Biochem J. 151:1975;173-180.
21. +-ATPase activities in adult and aged rat brain. Mech Ageing Dev. 122:2001;491-501.
22. +-ATPase. Z Naturforsch. 53c:1998;1055-1060.
23. +-ATPase. Z Naturforsch. 53c:1998;163-167.
24. Tsakiris S., Schulpis K.H. Alanine reverses the inhibitory effect of phenylalanine on acetylcholinesterase activity. Z Naturforsch. 57c:2002;506-511.
25. Weil-Maiherbe F. Blood adrenaline and intelligence. J Ment Sci. 101:1995;733-754.