Improved reliability of lymphoma diagnostics via PCR-based clonality testing: - Report of the BIOMED-2 Concerted Action BHM4-CT98-3936

Leukemia

Volumn 21, Issue 2, 2007, Pages 201-206

  van Krieken, J H J M ^a   Langerak, A W ^b   Macintyre, E A ^c   Kneba, M ^d   Hodges, E ^e   Sanz, R Garcia ^f   Morgan, G J ^g   Parreira, A ^h   Molina, T J ⁱ   Cabecadas J ^h   Gaulard, P ^j   Jasani, B ^k   Garcia, J F ^l   Ott, M ^m   Hannsmann, M L ⁿ   Berger, F ^o   Hummel, M ^p   Davi, F ^q   Bruggemann M ^d   Lavender, F L ^r   Schuuring, E ^s   Evans, P A S ^g   White, H ^r   Salles, G ^o   Groenen, P J T A ^a   Gameiro, P ^h   Pott, Ch ^d   van Dongen, J J M ^b   more..

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^f HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^g UNIVERSITY OF LEEDS   (United Kingdom)

^h INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

ⁱ HÔTEL DIEU   (France)

^j HENRI MONDOR HOSPITAL   (France)

^k CARDIFF UNIVERSITY   (United Kingdom)

^l Centro Nacional de Investigaciones Oncológicas   (Spain)

^m Luitpoldkrankenhaus ^*  (Germany)

ⁿ UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^o CENTRE HOSPITALIER LYON SUD   (France)

^p CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^q PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^r UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^s UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ARTICLE; B CELL LYMPHOMA; CLONAL VARIATION; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; FALSE NEGATIVE RESULT; FOLLICULAR LYMPHOMA; GENE REARRANGEMENT; HEALTH CARE COST; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; LYMPHOCYTE PROLIFERATION; LYMPHOMA; MANTLE CELL LYMPHOMA; PERIPHERAL T CELL LYMPHOMA; POLYMERASE CHAIN REACTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUALITY OF LIFE; RELIABILITY; STANDARDIZATION; T CELL LYMPHOMA; VALIDATION STUDY;

EID: 33846528976     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404467     Document Type: Article

References (40)

1. Hennessy BT, Hanrahan EO, Daly PA. Non-Hodgkin lymphoma: An update. Lancet Oncol 2004; 5: 341-353.
2. Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 2002; 100: 2292-2302.
3. Van Dongen JJM. Analysis of immunoglobulin genes and T cell receptor genes as a diagnostic tool for the detection of lymphoid malignancies. Neth J Med 1987; 31: 201-209.
4. Gleissner B, Maurer J, Thiel E. Detection of immunoglobulin heavy chain genes rearrangements in B-cell leukemias, lymphomas, multiple myelomas, monoclonal and polyclonal gammopathies. Leuk Lymphoma 2000; 39: 151-155.
5. Sen F, Vega F, Medeiros LJ. Molecular genetic methods in the diagnosis of hematologic neoplasms. Semin Diagn Pathol 2002; 19: 72-93.
6. Langerak AW, Van Krieken JH, Wolvers-Tettero IL, Kerkhof E, Mulder AH, Vrints LW et al. The role of molecular analysis of immunoglobulin and T cell receptor gene rearrangements in the diagnosis of lymphoproliferative disorders. J Clin Pathol 2001; 5: 565-567.
7. Tonegawa S. Somatic generation of antibody diversity. Nature 1983; 302: 575-581.
8. Davis MM, Björkman PJ. T-cell antigen receptor genes and T-cell recognition. Nature 1988; 334: 395-402.
9. van der Harst D, de Jong D, Limpens J, Kluin PM, Rozier Y, van Ommen GJ et al. Clonal B-cell populations in patients with idiopathic thrombocytopenic purpura. Blood 1990; 76: 2321-2326.
10. Van Dongen JJM, Wolvers-Tettero ILM. Analysis of immunoglobulin and T cell receptor genes. Part II: Possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders. Clin Chim Acta 1991; 198: 93-174.
11. Posnett DN, Sinha R, Kabak S, Russo C. Clonal populations of T cells in normal elderly humans: The T cell equivalent to "benign monoclonal gammapathy". J Exp Med 1994; 179: 609-618.
12. Malik UR, Oleksowicz L, Dutcher JP, Ratech H, Borowitz MJ, Wiernik PH. Atypical clonal T-cell proliferation in infectious mononucleosis. Med Oncol 1996; 13: 207-213.
13. Hoeve MA, Krol AD, Philippo K, Derksen PW, Veenendaal RA, Schuuring E et al. Limitations of clonality analysis of B cell proliferations using CDR3 polymerase chain reaction. Mol Pathol 2000; 53: 194-200.
14. Smith BR, Weinberg DS, Robert NJ, Towle M, Luther E, Pinkus GS et al. Circulating monoclonal B lymphocytes in non-Hodgkin's lymphoma. N Engl J Med 1984; 311: 1476-1481.
15. Gelb AB, Rouse RV, Dorfman RF, Warnke RA. Detection of immunophenotypic abnormalities in paraffin-embedded B-lineage non-Hodgkin's lymphomas. Am J Clin Pathol 1994; 102: 825-834.
16. Ashton-Key M, Jessup E, Isaacson PG. Immunoglobulin light chain staining in paraffin-embedded tissue using a heat mediated epitope retrieval method. Histopathology 1996; 29: 525-531.
17. Beishuizen A, Verhoeven MA, Mol EJ, Breit TM, Wolvers-Tettero ILM, Van Dongen JJM. Detection of immunoglobulin heavy-chain gene rearrangements by Southern blot analysis: Recommendations for optimal results. Leukemia 1993; 7: 2045-2053.
18. Langerak AW, Wolvers-Tettero ILM, Van Dongen JJM. Detection of T cell receptor beta (TCRB) gene rearrangement patterns in T cell malignancies by Southern blot analysis. Leukemia 1999; 13: 965-974.
19. Van Krieken JH, Elwood L, Andrade RE, Jaffe ES, Cossman J, Medeiros LJ. Rearrangement of the T-cell receptor delta chain gene in T-cell lymphomas with a mature phenotype. Am J Pathol 1991; 139: 161-168.
20. Langerak AW, Szczepanski T, Van der Burg M, Wolvers-Tettero IL, Van Dongen JJM. Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations. Leukemia 1997; 11: 2192-2199.
21. Gonzalez M, Gonzalez D, Lopez-Perez R, Garcia-Sanz R, Chillon MC, Balanzategui A et al. Heteroduplex analysis of VDJ amplified segments from rearranged IgH genes for clonality assessments in B-cell non-Hodgkin's lymphoma. A comparison between different strategies. Haematologica 1999; 84: 779-784.
22. Derksen PW, Langerak AW, Kerkhof E, Wolvers-Tettero IL, Boor PP, Mulder AH et al. Comparison of different polymerase chain reaction-based approaches for clonality assessment of immunoglobulin heavy-chain gene rearrangements in B-cell neoplasia. Mod Pathol 1999; 12: 794-805.
23. Krafft AE, Taubenberger JK, Sheng ZM, Bijwaard KE, Abbondanzo SL, Aguilera NS et al. Enhanced sensitivity with a novel TCR gamma PCR assay for clonality studies in 569 formalin-fixed, paraffin-embedded (FFPE) cases. Mol Diagn 1999; 4: 119-133.
24. Assaf C, Hummel M, Dippel E, Goerdt S, Muller HH, Anagnostopoulos I et al. High detection rate of T-cell receptor beta chain rearrangements in T-cell lymphoproliferations by family specific polymerase chain reaction in combination with the GeneScan technique and DNA sequencing. Blood 2000; 96: 640-646.
25. Theriault C, Galoin S, Valmary S, Selves J, Lamant L, Roda D et al. PCR analysis of immunoglobulin heavy chain (IgH) and TcRgamma chain gene rearrangements in the diagnosis of lympho-proliferative disorders: results of a study of 525 cases. Mod Pathol 2000; 13: 1269-1279.
26. Sandberg Y, Heule F, Lam K, Lugtenburg PJ, Wolvers-Tettero IL, Van Dongen JJM et al. Molecular immunoglobulin/T-cell receptor clonality analysis in cutaneous lymphoproliferations. Experience with the BIOMED-2 standardized polymerase chain reaction protocol. Haematologica 2003; 88: 659-670.
27. Van Dongen JJM, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender L et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations. Report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17: 2257-2317.
28. Van Krieken JH, Langerak AW, San Miguel JF, Parreira A, Smith JL, Morgan GM et al. Clonality analysis for antigen receptor genes: Preliminary results from the Biomed-2 concerted action PL 96-3936. Hum Pathol 2003; 34: 359-361.
29. Droese J, Langerak AW, Groenen PJ, Brüggemann M, Neumann P, Wolvers-Tettero IL et al. Validation of BIOMED-2 multiplex PCR tubes for detection of TCRB gene rearrangements in T-cell malignancies. Leukemia 2004; 18: 1531-1538.
30. Evans PAS, Pott Ch, Groenen PJTA, Salles G, Davi F, Berger F et al. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets: Report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Submitted.
31. Brüggemann M, White H, Gaulard P, Garcia-Sanz R, Gameiro P, Oeschger S et al. Powerful strategy for PCR-based clonality assessment in T-cell malignancies: Report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia, (in press).
32. Langerak AW, Molina TJ, Lavender FL, Pearson D, Flohr T, Sambade C et al. PCR-based clonality testing in tissue samples with reactive lymphoproliferations: Usefulness and pitfalls: A study from the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia, (in press).
33. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds). World Health Organization classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. IARC Press: Lyon, 2001, pp 1-351.
34. Kneba M, Bolz I, Linke B, Hiddemann W. Analysis of rearranged T-cell receptor beta-chain genes by polymerase chain reaction (PCR) DNA sequencing and automated high resolution PCR fragment analysis. Blood 1995; 86: 3930-3937.
35. Foss HD, Anagnostopoulos I, Araujo I, Assaf C, Demel G, Kummer JA et al. Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules. Blood 1996; 88: 4005-4011.
36. Van der Burg M, Tumkaya T, Boerma M, De Bruin-Versteeg S, Langerak AW, Van Dongen JJM. Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at the IGL locus. Blood 2001; 97: 1001-1008.
37. Van Zelm MC, Van der Burg M, De Ridder D, Barendregt BH, De Haas EF, Reinders MJ et al. Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression. J Immunol 2005; 175: 5912-5922.
38. Dik WA, Pike-Overzet K, Weerkamp F, De Ridder D, De Haas EF, Baert MR et al. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med 2005; 201: 1715-1723.
39. Langerak AW, Nadel B, De Torbal A, Wolvers-Tettero IL, Van Gastel-Mol EJ, Verhaaf B et al. Unraveling the consecutive recombination events in the human IGK locus. J Immunol 2004; 173: 3878-3888.
40. Droese J, Langerak AW, Groenen PJ, Bruggemann M, Neumann P, Wolvers-Tettero IL et al. Validation of BIOMED-2 multiplex PCR tubes for detection of TCRB gene rearrangements in T-cell malignancies. Leukemia 2004; 18: 1531-1538.