Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage

Human Reproduction

Volumn 22, Issue 2, 2007, Pages 440-443

  Hirschfeld, A F ^a   Jiang, R ^b   Robinson, W P ^b   McFadden, D E ^b   Turvey, S E ^a  

^a BC CHILDREN S HOSPITAL   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Innate immunity; Lipopolysaccharide; Miscarriage; Polymorphism; TLR4

Indexed keywords

ASPARAGINE; CHAPERONE; GLYCINE; ISOLEUCINE; LIPOPOLYSACCHARIDE; THREONINE; TOLL LIKE RECEPTOR 4;

ARTICLE; CASE CONTROL STUDY; CHROMOSOME ANALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; DNA DETERMINATION; EMBRYO; EMBRYO MEMBRANE; FEMALE; FETUS; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC CODE; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; NEWBORN; POLYMERASE CHAIN REACTION; PROTEIN DETERMINATION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SPONTANEOUS ABORTION; UMBILICAL CORD BLOOD;

ANIMALIA;

EID: 33846515974     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/del377     Document Type: Article

References (45)

1. Abrahams VM, Bole-Aldo P, Kim YM, Straszewski-Chavez SL, Chaiworapongsa T, Romero R and Mor G (2004) Divergent trophoblast responses to bacterial products mediated by TLRs. J Immunol 173,4286-4296.
2. Abrahams VM, Visintin I, Aldo PB, Guller S, Romero R and Mor G (2005) A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells. J Immunol 175,8096-8104.
3. Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Corbett SA, Calvano SE and Lowry SF (2002) Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 186,1522-1525.
4. Ameziane N, Beillat T, Verpillat P, Chollet-Martin S, Aumont MC, Seknadji P, Lamotte M, Lebret D, Ollivier V and de Prost D (2003). Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol 23,e61-e64.
5. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL and Schwartz DA (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 25,187-191.
6. von Aulock S, Schroder NW, Gueinzius K, Traub S, Hoffmann S, Graf K, Dimmeler S, Hartung T, Schumann RR and Hermann C (2003) Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide-induced cytokine release in human whole blood. J Infect Dis 188,938-943.
7. Baines MG, Duclos AJ, de Fougerolles AR and Gendron RL (1996) Immunological prevention of spontaneous early embryo resorption is mediated by non-specific immunosimulation. Am J Reprod Immunol 35,34-42.
8. Balistreri CR, Candore G, Colonna-Romano G, Lio D, Caruso M, Hoffmann E, Franceschi C and Caruso C (2004) Role of Toll-like receptor 4 in acute myocardial infarction and longevity. JAMA 292,2339-2340.
9. Boekholdt SM, Agema WR, Peters RJ, Zwinderman AH, van der Wall EE, Reitsma PH, Kastelein JJ and Jukema JW (2003) Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events. Circulation 107,2416-2421.
10. Chaouat G, Ledee-Bataille N, Dubanchet S, Zourbas S, Sandra O and Martal J (2004) Reproductive immunology 2003: Reassessing the Th1/Th2 paradigm? Immunol Lett 92,207-214.
11. Clark DA, Banwatt D and Chaouat G (1993) Effect of prostaglandin synthesis inhibitors on spontaneous and endotoxin-induced abortion in mice. J Reprod Immunol 24,29-44.
12. Clark DA, Arck PC and Chaouat G (1999) Why did your mother reject you? Immunogenetic determinants of the response to environmental selective pressure expressed at the uterine level. Am J Reprod Immunol 41,5-22.
13. Clark DA, Yu G, Arck PC, Levy GA and Gorczynski RM (2003) MD-1 is a critical part of the mechanism causing Th1-cytokine-triggered murine fetal loss syndrome. Am J Reprod Immunol 49,297-307.
14. Clark DA, Manuel J, Lee L, Chaouat G, Gorczynski RM and Levy GA (2004) Ecology of danger-dependent cytokine-boosted spontaneous abortion in the CBA x DBA/2 mouse model. I. Synergistic effect of LPS and (TNF-alpha + IFN-gamma) on pregnancy loss. Am J Reprod Immunol 52,370-378.
15. Dabbagh K and Lewis DB (2003) Toll-like receptors and T-helper-1/ T-helper-2 responses. Curr Opin Infect Dis 16,199-204.
16. Daels PF, Starr M, Kindahl H, Fredriksson G, Hughes JP and Stabenfeldt GH (1987) Effect of Salmonella typhimurium endotoxin on PGF-2 alpha release and fetal death in the mare. J Reprod Fertil Suppl 35,485-492.
17. Deb K, Chaturvedi MM and Jaiswal YK (2004) A 'minimum dose' of lipopolysaccharide required for implantation failure: Assessment of its effect on the maternal reproductive organs and interleukin-1alpha expression in the mouse. Reproduction 128,87-97.
18. Erridge C, Stewart J and Poxton IR (2003) Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J Exp Med 197,1787-1791.
19. Giri SN, Emau P, Cullor JS, Stabenfeldt GH, Bruss ML, Bondurant RH and Osburn BI (1990) Effects of endotoxin infusion on circulating levels of eicosanoids, progesterone, cortisol, glucose and lactic acid, and abortion in pregnant cows. Vet Microbiol 21,211-231.
20. van der Graaf C, Kullberg BJ, Joosten L, Verver-Jansen T, Jacobs L, Van der Meer JW and Netea MG (2005) Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism. Cytokine 30,264-268.
21. Hay PE, Lamont RF, Taylor-Robinson D, Morgan DJ, Ison C and Pearson J (1994) Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. BMJ 308,295-298.
22. Heesen M, Wessiepe M, Kunz D, Vasickova K and Blomeke B (2003) Rapid and reliable genotyping for the Toll-like receptor 4 A896G polymorphism using fluorescence-labeled hybridization probes in a real-time polymerase chain reaction assay. Clin Chim Acta 333,47-49.
23. Hill JA, Polgar K and Anderson DJ (1995) T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA 273,1933-1936.
24. Holmlund U, Cebers G, Dahlfors AR, Sandstedt B, Bremme K, Ekstrom ES and Scheynius A (2002) Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta. Immunology 107,145-151.
25. Kamiyama S, Teruya Y, Nohara M and Kanazawa K (2004) Impact of detection of bacterial endotoxin in menstrual effluent on the pregnancy rate in in vitro fertilization and embryo transfer. Fertil Steril 82,788-792.
26. Karhukorpi J, Laitinen T and Karttunen R (2003) Searching for links between endotoxin exposure and pregnancy loss: CD14 polymorphism in idiopathic recurrent miscarriage. Am J Reprod Immunol 50,346-350.
27. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J and Schwartz DA (2002) Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 347,185-192.
28. Korn AP, Bolan G, Padian N, Ohm-Smith M, Schachter J and Landers DV (1995) Plasma cell endometritis in women with symptomatic bacterial vaginosis. Obstet Gynecol 85,387-390.
29. Kumazaki K, Nakayama M, Yanagihara I, Suehara N and Wada Y (2004) Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis. Hum Pathol 35,47-54.
30. Lomax B, Tang S, Separovic E, Phillips D, Hillard E, Thomson T and Kalousek DK (2000) Comparative genomic hybridization in combination with flow cytometry improves results of cytogenetic analysis of spontaneous abortions. Am J Hum Genet 66,1516-1521.
31. Lorenz E, Hallman M, Marttila R, Haataja R and Schwartz DA (2002a) Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish population. Pediatr Res 52,373-376.
32. Lorenz E, Mira JP, Frees KL and Schwartz DA (2002b) Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 162,1028-1032.
33. Marzi M, Vigano A, Trabattoni D, Villa ML, Salvaggio A, Clerici E and Clerici M (1996) Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol 106,127-133.
34. Michimata T, Sakai M, Miyazaki S, Ogasawara MS, Suzumori K, Aoki K, Nagata K and Saito S (2003) Decrease of T-helper 2 and T-cytotoxic 2 cells at implantation sites occurs in unexplained recurrent spontaneous abortion with normal chromosomal content. Hum Reprod 18,1523-1528.
35. Peipert JF, Montagno AB, Cooper AS and Sung CJ (1997) Bacterial vaginosis as a risk factor for upper genital tract infection. Am J Obstet Gynecol 177,1184-1187.
36. Piccinni MP, Beloni L, Livi C, Maggi E, Scarselli G and Romagnani S (1998) Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med 4,1020-1024.
37. Raghupathy R, Makhseed M, Azizieh F, Hassan N, Al-Azemi M and Al-Shamali E (1999) Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions. Cell Immunol 196,122-130.
38. Ralph SG, Rutherford AJ and Wilson JD (1999) Influence of bacterial vaginosis on conception and miscarriage in the first trimester: Cohort study. BMJ 319,220-223.
39. Romero R, Espinoza J and Mazor M (2004) Can endometrial infection/ inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil Steril 82,799-804.
40. Schlafer DH, Yuh B, Foley GL, Elssaser TH, Sadowsky D and Nathanielsz PW (1994) Effect of Salmonella endotoxin administered to the pregnant sheep at 133-142 days gestation on fetal oxygenation, maternal and fetal adrenocorticotropic hormone and cortisol, and maternal plasma tumor necrosis factor alpha concentrations. Biol Reprod 50,1297-1302.
41. Smirnova I, Mann N, Dols A, Derkx HH, Hibberd ML, Levin M and Beutler B (2003) Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci USA 100,6075-6080.
42. Takeda K, Kaisho T and Akira S (2003) Toll-like receptors. Annu Rev Immunol 21,335-376.
43. Van Rijn BB, Roest M, Franx A, Bruinse HW and Voorbij HA (2004) Single step high-throughput determination of Toll-like receptor 4 polymorphisms. J Immunol Methods 289,81-87.
44. Wegmann TG, Lin H, Guilbert L and Mosmann TR (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon? Immunol Today 14,353-356.
45. Zinaman MJ, Clegg ED, Brown CC, O'Connor J and Selevan SG (1996) Estimates of human fertility and pregnancy loss. Fertil Steril 65,503-509.