The chemical synapse goes electric: Ca2+- and voltage-sensitive GPCRs control neurotransmitter release

Trends in Neurosciences

Volumn 30, Issue 2, 2007, Pages 54-61

  Parnas, Hanna ^a   Parnas, Itzchack ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AUTORECEPTOR; CALCIUM; CORE PROTEIN; G PROTEIN COUPLED RECEPTOR;

CALCIUM TRANSPORT; DEPOLARIZATION; ELECTRIC POTENTIAL; HUMAN; NEGATIVE FEEDBACK; NERVE CELL PLASTICITY; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR AFFINITY; REVIEW; SYNAPSE; SYNAPTIC POTENTIAL;

ANIMALS; CALCIUM; ELECTROPHYSIOLOGY; HUMANS; NEUROTRANSMITTER AGENTS; RECEPTORS, G-PROTEIN-COUPLED; SYNAPSES;

EID: 33846502144     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2006.12.001     Document Type: Review

References (57)

1. Parnas H., et al. Autoreceptors, membrane potential and the regulation of transmitter release. Trends Neurosci. 23 (2000) 60-68
2. Khanin R., et al. On the feedback between theory and experiment in elucidating the molecular mechanism underlying neurotransmitter release. Bull. Math. Biol. 68 (2006) 997-1009
3. Nicholls J.G., et al. From Neuron to Brain. 4th edn (2001), Sinauer Associates
4. Gether U. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr. Rev. 21 (2000) 90-113
5. Starke K., et al. Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol. Rev. 69 (1989) 864-989
6. Takahashi M., et al. Calcium influx-independent depression of transmitter release by 5-HT at lamprey spinal cord synapses. J. Physiol. 532 (2001) 323-336
7. 2 entry. Science 292 (2001) 293-297
8. Stephens G.J., and Mochida S. G protein βγ subunits mediate presynaptic inhibition of transmitter release from rat superior cervical ganglion neurones in culture. J. Physiol. 563 (2005) 765-776
9. Santafe M.M., et al. Muscarinic autoreceptors modulate transmitter release through protein kinase C and protein kinase A in the rat motor nerve terminal. Eur. J. Neurosci. 23 (2006) 2048-2056
10. Photowala H., et al. G protein βγ-subunits activated by serotonin mediate presynaptic inhibition by regulating vesicle fusion properties. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 4281-4286
11. Yusim K., et al. Theory of neurotransmitter release control based on voltage-dependent interaction between autoreceptors and proteins of the exocytotic machinery. Bull. Math. Biol. 61 (1999) 701-725
12. Linial M., et al. Voltage-dependent interaction between the muscarinic ACh receptor and proteins of the exocytic machinery. J. Physiol. 504 (1997) 251-258
13. Ilouz N., et al. Depolarization affects the binding properties of muscarinic acetylcholine receptors and their interaction with proteins of the exocytic apparatus. J. Biol. Chem. 274 (1999) 29519-29528
14. Slutsky I., et al. Presynaptic effects of muscarine on ACh release at the frog neuromuscular junction. J. Physiol. 514 (1999) 769-782
15. 2 muscarinic G-protein-coupled receptor is voltage sensitive. J. Biol. Chem. 278 (2003) 22482-22491
16. Ohana L., et al. The metabotropic glutamate G-protein-coupled receptors mGluR3 and mGluR1a are voltage sensitive. J. Biol. Chem. 281 (2006) 24204-24215
17. B G-protein-coupled receptor voltage sensitive?. Rev. Neurosci. 16 (2005) S16
18. Katz B., and Miledi R. The role of calcium in neuromuscular facilitation. J. Physiol. 308 (1968) 481-492
19. Schneggenburger R., and Neher E. Presynaptic calcium and control of vesicle fusion. Curr. Opin. Neurobiol. 15 (2005) 266-274
20. Felmy F., et al. Probing the intracellular calcium sensitivity of transmitter release during synaptic facilitation. Neuron 37 (2003) 801-811
21. 2+. J. Neurophysiol. 81 (1999) 634-642
22. Bollmann J.H. Calcium sensitivity of glutamate release in calyx-type terminal. Science 289 (2000) 953-957
23. Schneggenburger R., and Neher E. Intracellular calcium dependence of transmitter release rates at fast central synapse. Nature 406 (2000) 889-893
24. Augustin G.J. How does calcium trigger neurotransmitter release?. Curr. Opin. Neurobiol. 3 (2001) 320-326
25. 2+ channel clustering and vesicle release. Science 312 (2006) 1051-1054
26. Atwood H.L. Gatekeeper at the synapse. Science 312 (2006) 1008-1009
27. Katz B., and Miledi R. The effect of calcium on acetylcholine release from motor nerve terminals. Proc. R. Soc. Lond. B. Biol. Sci. 161 (1965) 469-503
28. 2 muscarinic receptors are involved in controlling the kinetics of ACh release at the frog neuromuscular junction. J. Physiol. 536 (2001) 717-725
29. 2-muscarinic receptors in control of the kinetics of acetylcholine release. J. Neurophysiol. 89 (2003) 1954-1967
30. 2+-independent feedback inhibition of acetylcholine release in frog neuromuscular junction. J. Neurosci. 22 (2002) 3426-3433
31. 2 muscarinic receptors. J. Neurophysiol. 93 (2005) 3257-3269
32. Kupchik Y.M., et al. Depolarization initiates release in crayfish by relief of a tonic block imposed by presynaptic inhibitory autoreceptors. Rev. Neurosci. 16 (2005) S39
33. Bradley S.R., et al. Activation of group II metabotropic glutamate receptors inhibits synaptic excitation of substantia nigra pars reticulate in rat neocortex. J. Neurosci. 20 (2000) 3085-3094
34. Bandrowski A.E., et al. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J. Neurophysiol. 89 (2003) 1308-1316
35. Bacci A., et al. Modulation of neocortical interneurons: extrinsic influences and exercises in self-control. Trends Neurosci. 28 (2005) 602-610
36. VanRullen R., et al. Spike times make sense. Trends Neurosci. 28 (2005) 1-4
37. Haag J., et al. Fly motion vision is based on Reichardt detectors regardless of the signal-to-noise ratio. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 16333-16338
38. Carr C.E., and Konishi M. A circuit for detection of interaural time differences in the brain stem of the barn owl. J. Neurosci. 10 (1990) 3227-3246
39. Dan Y., and Poo M.M. Spike timing-dependent plasticity of neural circuits. Neuron 44 (2004) 23-30
40. Guetiq R., and Sompolinsky H. The tempotron: a neuron that learns spike timing-based decisions. Nat. Neurosci. 9 (2006) 420-428
41. Markram H., et al. Potential for multiple mechanisms, phenomena and algorithms for synaptic plasticity at single synapses. Neuropharmacology 37 (1998) 489-500
42. Wess J. Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications. Annu. Rev. Pharmacol. Toxicol. 44 (2004) 423-450
43. Bezanilla F. The voltage-sensor structure in voltage-gated channel. Trends Biochem. Sci. 30 (2005) 166-168
44. 2+ oscillations in rat megakaryocytes. J. Physiol. 524 (2000) 437-446
45. 2+ mobilization in the rat megakaryocyte. J. Physiol. 555 (2003) 61-70
46. Martinez-Pinna J., et al. Direct voltage control of signaling via P2Y1 and other Gαq-coupled receptors. J. Biol. Chem. 280 (2005) 1490-1498
47. Perroy J., et al. Permissive effect of voltage on mGlu 7 receptor subtype signaling in neurons. J. Biol. Chem. 277 (2002) 1223-1228
48. Bolton T.B., and Zholos A.V. Potential synergy: voltage-driven steps in receptor-G protein coupling and beyond. Sci. STKE 210 (2003) pe52
49. Armstrong C.M., and Bezanilla F. Currents related to movement of the gating particles of the sodium channels. Nature 242 (1973) 459-461
50. Ben-Chaim Y., et al. Movement of 'gating charge' is coupled to ligand binding in a G-protein coupled muscarinic receptor. Nature 444 (2006) 106-109
51. 2+-activated K+ channels. Nat. Neurosci. 3 (2000) 566-571
52. 2+ channel clusters persist at isolated presynaptic terminals. Eur. J. Neurosci. 23 (2006) 1391-1396
53. 2+ signal for phasic transmitter release at the rat calyx of Held. J. Physiol. 547 (2003) 665-689
54. Rizo J., et al. Unravling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release. Trends Cell Biol. 16 (2006) 339-350
55. 2+-triggered exocytosis. Science 304 (2004) 289-292
56. Ravetch J.V., and Lanier L.L. Immune inhibitory receptors. Science 290 (2000) 84-89
57. Stefani E., and Bezanilla F. Cut-open voltage-clamp technique. Methods Enzymol. 293 (1998) 300-318