Isotope dilution LC/MS/MS for the detection of nerve agent exposure in urine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 846, Issue 1-2, 2007, Pages 42-50

  Ciner, Frederic L ^a   McCord, Carla E ^a   Plunkett Jr , Roy W ^a   Martin, Michael F ^a   Croley, Timothy R ^a  

^a Department of General Services   (United States)

Author keywords

LC MS MS; Method development; Nerve agents

Indexed keywords

BIOLOGICAL MATERIALS; INSECTICIDES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; METABOLITES; STATISTICAL METHODS;

METHOD DEVELOPMENT; NERVE AGENTS; REPRODUCIBILITY; STANDARD DEVIATIONS;

PHOSPHORUS COMPOUNDS;

CYCLOSARIN; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; ORGANOPHOSPHATE INSECTICIDE; ORGANOPHOSPHORUS COMPOUND; SARIN; SOMAN;

ARTICLE; CHEMICAL ANALYSIS; HUMAN; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; URINALYSIS; VALIDATION STUDY;

CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; ISOTOPES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 33846463090     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.08.008     Document Type: Article

References (15)

1. Harris L.W., Braswell L.M., Fleisher J.P., and Cliff W.J. Biochem. Pharmacol. 13 (1964) 1129
2. Reynolds M.L., Little P.J., Thomas B.F., Bagley R.B., and Martin B.R. Toxicol. Appl. Pharmacol. 80 (1985) 409
3. D.E. Lenz, J. Boisseau, D.M. Maxwell, E. Heir, Proceedings of the 6th Medical Chemical Defense Bioscience Review, 1987, p. 201, AD B121516.
4. Suzuki O., Seno H., Watanabe-Suzuki K., and Ishii A. Forensic Sci. Int. 113 (2000) 331
5. Bryant P.J.R., Ford-Moore A.H., Perry B.J., Wardrop A.W.H., and Watkins T.F. J. Chem. Soc. 1 (1960) 1553
6. Black R.M., Clarke R.J., Read R.W., and Reid M.T.J. J. Chromatogr. A 662 (1994) 301
7. Black R.M., and Read R.W. J. Chromatogr. A 759 (1997) 79
8. Black R.M., and Read R.W. J. Chromatogr. A 794 (1998) 233
9. Black R.M., and Read R.W. J. Chromatogr. A 849 (1999) 169
10. Creasy W.R. J. Am. Soc. Mass Spectrom. 10 (1999) 440
11. Steiner W.E., Clowers B.H., Matz L.M., Siems W.F., and Hill Jr. H.H. Anal. Chem. 74 (2002) 4343
12. Polhuijs M., Langenberg J.P., and Benschop H.P. Toxicol. Appl. Pharmacol. 146 (1997) 156
13. Driskell W.J., Shih M., Needham L.L., and Barr D.B. J. Anal. Toxicol. 26 (2002) 6
14. Barr J.R., Driskell W.J., Aston L.S., and Martinez R.A. J. Anal. Toxicol. 28 (2004) 372
15. Collins T., McCord C.E., Plunkett R.W., Martin M.F., and Croley T.R. Proceedings of the 52nd ASMS Conference on Mass Spectrometry and Allied Topics. Nashville, TN (May 2004)