Molecular insights of SAH enzyme catalysis and implication for inhibitor design

Journal of Theoretical Biology

Volumn 244, Issue 4, 2007, Pages 692-702

  Wei, Huachun ^a,b   Zhang, Rui ^b   Wang, Chunfang ^b   Zheng, Huiqin ^b   Li, Aixiu ^b   Chou, Kuo Chen ^c   Wei, Dong Qing ^a,c  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b TIANJIN NORMAL UNIVERSITY   (China)

^c GORDON LIFE SCIENCE INSTITUTE   (United States)

Author keywords

Docking; Enzyme catalysis; Inhibitor design; S adenosylhomocysteine hydrolase (SAH)

Indexed keywords

ADENOSINE; ADENOSYLHOMOCYSTEINASE; CHEMICAL COMPOUND; ENZYME INHIBITOR; HOMOCYSTEINE; METHYL GROUP; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

CATALYSIS; ENZYME ACTIVITY; HYDROLYSIS; INHIBITION; LIFE CYCLE; MOLECULAR ANALYSIS; VIRUS;

ARTICLE; CHEMICAL REACTION KINETICS; CHINESE MEDICINE; COMPUTER ANALYSIS; DATA BASE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; FUNCTIONAL PROTEOMICS; HUMAN; LIFE CYCLE; METHYLATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN MODIFICATION; STRUCTURAL PROTEOMICS; STRUCTURE ANALYSIS; THEORETICAL MODEL; VIRUS REPLICATION;

ADENINE; ADENOSYLHOMOCYSTEINASE; BINDING SITES; CATALYSIS; DATABASES, FACTUAL; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; LIGANDS; MEDICINE, CHINESE TRADITIONAL; METHYLATION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RIBOSE;

EID: 33846449105     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2006.09.011     Document Type: Article

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