Gene expression profiles of drug-metabolizing enzymes and transporters with an overexpression of hepatocyte growth factor

Liver International

Volumn 27, Issue 1, 2007, Pages 109-119

  Kakizaki, Satoru ^a   Yamazaki, Yuichi ^a   Kosone, Takashi ^a   Horigichi, Norio ^a   Sohara, Naondo ^a   Sato, Ken ^a   Takagi, Hitoshi ^a   Yoshinari, Kouichi ^b   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; Drug transporters; Drug metabolizing enzyme; Hepatocyte growth factor; Nuclear receptor; Transferase

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CARBOXYLESTERASE; CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450 1A2; CYTOCHROME P450 2B; CYTOCHROME P450 2B10; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 2D9; CYTOCHROME P450 3A11; CYTOCHROME P450 4A; CYTOCHROME P450 4A10; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HETERODIMER; OLIGONUCLEOTIDE; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; SCATTER FACTOR; SULFOTRANSFERASE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; LIVER REGENERATION; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; TRANSGENIC MOUSE; UNINDEXED SEQUENCE; WILD TYPE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; GENE EXPRESSION PROFILING; HEPATOCYTE GROWTH FACTOR; LIVER; MALE; MICE; MICE, TRANSGENIC; MICROSOMES, LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOBARBITAL; PYRIDINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER;

EID: 33846447855     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2006.01384.x     Document Type: Article

References (38)

1. Xu C, Li CY, Kong AN. Induction of phase I, II and III drug metabolism/ transport by xenobiotics. Arch Pharm Res 2005; 28: 249-68.
2. Marie IJ, Dalet C, Banchard JM, et al. Inhibition of cytochrome P-450p (P450IIIA1) gene expression during liver regeneration from two-thirds hepatectomy in the rat. Biochem Pharmacol 1988; 37: 3515-21.
3. Habib SL, Srikanth NS, Scappaticci FA, et al. Altered expression of cytochrome P450 mRNA during chemical-induced hepatocarcinogenesis and following partial hepatectomy. Toxicol Appl Pharmacol 1994; 124: 139-48.
4. Hakkola J, Pasanen M, Purkunen R, et al. Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver. Biochem Pharmacol 1994; 48: 59-64.
5. Degawa M, Miura S, Yoshinari K, Hashimoto Y. Altered expression of hepatic CYP1A enzymes in rat hepatocarcinogenesis. Jpn J Cancer Res 1995; 86: 535-9.
6. Grant MH, Duthie SJ, Gray AG, Burke MD. Mixed function oxidase and UDP-glucuronyltransferase activities in the human HepG2 hepatoma cell line. Biochem Pharmacol 1988; 37: 4111-6.
7. Donato MT, Bassi AM, Gómez-Lechón MJ, et al. Evaluation of the xenobiotic biotransformation capability of rodent hepatoma cell lines in comparison with rat hepatocytes. In Vitro Cell Dev Biol 1994; 30A: 574-80.
8. Matsumoto K, Nakamura T. Hepatocyte growth factor: Molecular structure, roles in liver regeneration, and other biological functions. Crit Rev Oncog 1992; 3: 27-54.
9. Gómez-Lechón MJ, Castell JV, Guillén MI, et al. Effects of hepatocyte growth factor (HGF) on the growth and metabolism of human hepatocytes in primary culture. Hepatology 1995; 21: 1248-54.
10. Nishizaki T, Takenake K, Yoshizumi T, et al. Alteration in levels of human hepatocyte growth factor following hepatectomy. J Am Coll Surg 1995; 181: 6-10.
11. Selden C, Johnstone R, Darby H, Gupta S, Hodgson HJF. Human serum does contain a high molecular weight hepatocyte growth factor: Studies pre- and post-hepatic resection. Biochem Biophys Res Commun 1986; 139: 361-6.
12. Tsubouchi H, Hirono S, Gohda E, et al. Clinical significance of human hepatocyte growth factor in blood from patients with fulminant hepatic failure. Hepatology 1989; 9: 875-81.
13. Shimizu I, Ichihara A, Nakamura T. Hepatocyte growth factor in ascites from patients with cirrhosis. J Biochem 1991; 109: 14-18.
14. Miki C, Iriyama K, Strain A, et al. Clinical significance of serum hepatocyte growth factor in orthotopic liver transplantation. Surgery 1996; 119: 505-10.
15. Donato MT, Gomez-Lechon MJ, Jover R, Nakamura T, Castell JV. Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture. J Pharmacol Exp Ther 1998; 284: 760-7.
16. Greuet J, Pichard L, Ourlin JC, et al. Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture. Hepatology 1997; 25: 1166-75.
17. Hohne M, Becker-Rabbenstein V, Kahl GF, Taniguchi H. Regulation of cytochrome P-450 CYPIA1 gene expression and protooncogene expression by growth factors in primary hepatocytes. FEBS Lett 1990; 273: 219-22.
18. Aubrecht J, Hirsch-Ernst KI, Becker-Rabbenstein V, Kahl GF, Taniguchi H, Hohne MW. Induction of cytochrome P-4502B1-related mouse cytochrome P-450 and regulation of its expression by epidermal growth factor/ transforming growth factor α in primary hepatocyte culture. Biochem Pharmacol 1995; 50: 781-5.
19. Ching KZ, Tenney KA, Chen J, Morgan ET. Suppression of constitutive cytochrome P450 gene expression by epidermal growth factor receptor ligands in cultured rat hepatocytes. Drug Metab Dis 1996; 24: 542-6.
20. Klinger W, Karge E. Interaction of induction, ontogenetic development and liver regeneration on the monooxygenase level. Exp Pathol 1987; 31: 117-24.
21. Chen ZY, White CC, Eaton DL. Decreased expression of cytochrome P450 mRNAs and related steroid hydroxylation activities in hepatic hyperplastic nodules in male F344 rats. Toxicol Appl Pharmacol 1993; 123: 151-9.
22. Takayama H, La Rochelle WJ, Anver M, Bockman DE, Merlino G. Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci USA 1996; 93: 5866-71.
23. Miyata M, Takano H, Guo LQ, Nagata K, Yamazoe Y. Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity. Carcinogenesis 2004; 25: 203-9.
24. Gonzalez FJ. The molecular biology of cytochrome P450s. Pharmacol Ther 1989; 40: 243-88.
25. Jarukamjorn K, Sakuma T, Miyaura J, Nemoto N. Different regulation of the expression of mouse hepatic cytochrome P450 2B enzymes by glucocorticoid and phenobarbital. Arch Biochem Biophys 1999; 369: 89-99.
26. Sueyoshi T, Negishi M. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol 2001; 41: 123-43.
27. Belanger A, Hum DW, Beaulieu M, et al. Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues. J Steroid Biochem Mol Biol 1998; 65: 301-10.
28. Honkakoski P, Moore R, Gynther J, Negishi M. Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes. J Biol Chem 1996; 271: 9746-53.
29. Kietzmann T, Hirsch-Ernst KI, Kahl GF, Jungermann K. Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: Role of epidermal growth factor and perivenous oxygen tension. Mol Pharmacol 1999; 56: 46-53.
30. Schuetz EG, Schuetz JD, May B, Guzelian PS. Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. J Biol Chem 1990; 265: 1188-92.
31. Bauer D, Wolfram N, Kahl GF, Hirsch-Ernst KI. Transcriptional regulation of CYP2B1 induction in primary rat hepatocyte cultures: Repression by epidermal growth factor is mediated via a distal enhancer region. Mol Pharmacol 2004; 65: 172-80.
32. Ueda A, Hamadeh HK, Webb HK, et al. Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol 2002; 61: 1-6.
33. Pascussi JM, Dvorak Z, Gerbal-Chaloin S, Assenat E, Maurel P, Vilarem MJ. Pathophysiological factors affecting CAR gene expression. Drug Metab Rev 2003; 35: 255-68.
34. Sakuma T, Honma R, Maguchi S, Tamaki H, Nemoto N. Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat. Xenobiotica 2001; 31: 223-37.
35. Lindross PM, Zarnegar R, Michalopoulos GK. Hepatocyte growth factor rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration. Hepatology 1991; 13: 743-9.
36. Kinoshita T, Hirao S, Matsumoto K, Nakamura T. Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy. Biochem Biophys Res Commun 1991; 177: 330-5.
37. Efimova EA, Glanemann M, Nussler AK, et al. Changes in serum levels of growth factors in healthy individuals after living related liver donation. Transplant Proc 2005; 37: 1074-5.
38. Sakata H, Takayama H, Sharp R, Rubin JS, Merlino G, LaRochelle WJ. Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ 1996; 7: 1513-23.