Protein and energy intake in advanced chronic kidney disease: How much is too much?

Seminars in Dialysis

Volumn 20, Issue 1, 2007, Pages 5-11

  Alp Ikizler, T ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALORIC INTAKE; CHRONIC KIDNEY FAILURE; DIABETES MELLITUS; HUMAN; INSULIN RESISTANCE; METABOLISM; NUTRITIONAL REQUIREMENT; PROTEIN INTAKE; RENAL REPLACEMENT THERAPY; REVIEW; UREMIA;

DIABETES MELLITUS; DIETARY PROTEINS; ENERGY INTAKE; HUMANS; INSULIN RESISTANCE; KIDNEY FAILURE, CHRONIC; NUTRITIONAL REQUIREMENTS; RENAL DIALYSIS; UREMIA;

EID: 33846444332     PISSN: 08940959     EISSN: 1525139X     Source Type: Journal    
DOI: 10.1111/j.1525-139X.2007.00231.x     Document Type: Review

References (72)

1. Bergstrom J: Protein catabolic factors in patients on renal replacement therapy. Adv Exp Med Biol 260:1-9, 1989
2. Bergstrom J: Nutrition and mortality in hemodialysis. J Am Soc Nephrol 6:1329-1341, 1995
3. Hakim RM, Levin N: Malnutrition in hemodialysis patients. Am J Kidney Dis 21:125-137, 1993
4. Ikizler TA, Hakim RM: Nutrition in end-stage renal disease. Kidney Int 50:343-357, 1996
5. Kopple JD. Causes of catabolism and wasting in acute or chronic renal failure. In: Robinson RR (ed). Nephrology, 2 edn. New York: Springer Verlag, 1984:1498-1520
6. Kopple JD: Effect of nutrition on morbidity and mortality in maintenance dialysis patients. Am J Kidney Dis 24:1002-1009, 1994
7. Mitch WE, Walser M: Nutritional therapy of the uremic patient. In: Rector FC, Brenner BM (eds). The Kidney, 4th edn. Philadelphia, PA: Saunders, 1991:2186-2222
8. Mitch WE, Goldberg AL: Mechanism of muscle wasting: the role of ubiquitin-proteasome pathway. N Engl J Med 335:1897-1905, 1997
9. Verdery RB: Malnutrition and chronic inflammation: causes or effects of frailty? Aging 1992:262-263, 1995
10. Churchill DN, Taylor DW, Cook RJ, LaPlante P, Barre P, Cartier P, Fay WP, Goldstein MB, Jindal K, Mandin H: Canadian hemodialysis morbidity study. Am J Kidney Dis 19:214-234, 1992
11. Iseki K, Kawazoe N, Fukiyama K: Serum albumin is a strong predictor of death in chronic dialysis patients. Kidney Int 44:115-119, 1993
12. Lowrie EG, Huang WH, Lew NL, Liu Y: The relative contribution of measured variables to death risk among hemodialysis patients. In: Friedman EA (ed). Death on Hemodialysis. Amsterdam: Kluwer Academic Publishers, 1994:121-141
13. Ikizler TA, Wingard RL, Harvell J, Shyr Y, Hakim RM: Association of morbidity with markers of nutrition and inflammation in chronic hemodialysis patients: a prospective study. Kidney Int 55:1945-1951, 1999
14. Collins AJ, Ma JZ, Umen A, Keshaviah P: Urea index and other predictors of hemodialysis patient survival. Am J Kidney Dis 23:272-282, 1993
15. Goldwasser P, Mittman M, Antignani A, Burrel D, Michel M-A, Collier T, Avram MM: Predictors of mortality on hemodialysis. J Am Soc Nephrol 3:1613-1622, 1993
16. Oksa H, Ahonen K, Pasternack A, Marnela KM: Malnutrition in hemodialysis patients. Scand J Urol Nephrol 25:157-161, 1991
17. Owen WF Jr, Lew NL, Liu Y, Lowrie EG, Lazarus JM: The urea reduction ratio and serum albumin concentrations as predictors of mortality in patients undergoing hemodialysis. N Engl J Med 329:1001-1006, 1993
18. Lim VS, Flanigan MJ: Protein intake in patients with renal failure: comments on the current NKF-DOQI guidelines for nutrition in chronic renal failure. Semin Dial 14:150-152, 2001
19. Ikizler TA, Greene J, Wingard RL, Parker RA, Hakim RM: Spontaneous dietary protein intake during progression of chronic renal failure. J Am Soc Nephrol 6:1386-1391, 1995
20. Kopple JD: National kidney foundation K/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis 37:S66-S70, 2001
21. Du J, Hu Z, Mitch WE: Cellular signals activating muscle proteolysis in chronic kidney disease: a two-stage process. Int J Biochem Cell Biol 37:2147-2155, 2005
22. Anderstam B, Mamoun AH, Sodersten P, Bergstrom J: Middle-sized molecule fractions isolated from uremic ultrafiltrate and normal urine inhibit ingestive behavior in the rat. J Am Soc Nephrol 7:2453-2460, 1996
23. Mamoun AH, Sodersten P, Anderstam B, Bergstrom J: Evidence of splanchnic-brain signaling in inhibition of ingestive behavior by middle molecules. J Am Soc Nephrol 10:309-314, 1999
24. Mamoun AH: Anorexia in patients with chronic renal failure-progress towards understanding the molecular basis. Nephrol Dial Transplant 13:2460-2463, 1998
25. Lim VS, Kopple JD: Protein metabolism in patients with chronic renal failure: role of uremia and dialysis. Kidney Int 58:1-10, 2000
26. Lim VS, Bier DM, Flanigan MJ, Sum-Ping ST: The effect of hemodialysis on protein metabolism: a leucine kinetic study. J Clin Invest 91:2429-2436, 1993
27. Reaich D, Channon SM, Scrimgeour CM, Daley SE, Wilkinson R, Goodship TH: Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation. Am J Physiol 265:E230-E235, 1993
28. Goodship TH, Mitch WE, Hoerr RA, Wagner DA, Steinman TI, Young VR: Adaptation to low-protein diets in renal failure: leucine turnover and nitrogen balance. J Am Soc Nephrol 1:66-75, 1990
29. Goodship TH, Lloyd S, Clague MB, Bartlett K, Ward MK, Wilkinson R: Whole body leucine turnover and nutritional status in continuous ambulatory peritoneal dialysis. Clin Sci (Lond) 73:463-469, 1987
30. Lim VS, Yarasheski KE, Flanigan MJ: The effect of uraemia, acidosis, and dialysis treatment on protein metabolism: a longitudinal leucine kinetic study. Nephrol Dial Transplant 13:1723-1730, 1998
31. Adey D, Kumar R, McCarthy JT, Nair KS: Reduced synthesis of muscle proteins in chronic renal failure. Am J Physiol Endocrinol Metab 278:E219-E225, 2000
32. Lim VS, Ikizler TA, Raj DS, Flanigan MJ: Does hemodialysis increase protein breakdown? Dissociation between whole-body amino acid turnover and regional muscle kinetics. J Am Soc Nephrol 16:862-868, 2005
33. Ikizler TA, Pupim RB, Brouillette JR, Levenhagen DK, Farmer K, Hakim RM, Flakoll PJ: Hemodialysis stimulates muscle and whole-body protein loss and alters substrate oxidation. Am J Physiol Endocrinol Metab 282:E107-E116, 2002
34. Raj DS, Zager P, Shah VO, Dominic EA, Adeniyi O, Blandon P, Wolfe R, Ferrando A: Protein turnover and amino acid transport kinetics in end-stage renal disease. Am J Physiol Endocrinol Metab 286:E136-E143, 2004
35. Caglar K, Fedje L, Dimmitt R, Hakim RM, Shyr Y, Ikizler TA: Therapeutic effects of oral nutritional supplementation during hemodialysis. Kidney Int 62:1054-1059, 2004
36. Pupim LB, Flakoll PJ, Levenhagen DK, Ikizler TA: Exercise augments the acute anabolic effects of intradialytic parenteral nutrition in chronic hemodialysis patients. Am J Physiol Endocrinol Metab 286:E589-597, 2004
37. Pupim RB, Flakoll PJ, Brouillette JR, Levenhagen DK, Hakim RM, Ikizler TA: Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J Clin Invest 110:483-492, 2002
38. Veeneman JM, Kingma HA, Boer TS, Stellaard F, De Jong PE, Reijngoud DJ, Huisman RM: Protein intake during hemodialysis maintains a positive whole body protein balance in chronic hemodialysis patients. Am J Physiol Endocrinol Metab 284:E954-965, 2003
39. Kaysen GA: The microinflammatory state in uremia: causes and potential consequences. J Am Soc Nephrol 12:1549-1557, 2001
40. Bergstrom J, Lindholm B, Lacson E Jr, Owen W Jr, Lowrie EG, Glassock RJ, Ikizler TA, Wessels FJ, Moldawer LL, Wanner C, Zimmermann J: What are the causes and consequences of the chronic inflammatory state in chronic dialysis patients? Semin Dial 13:163-175, 2000
41. Panichi V, Tetta C, Rindi P, Palla R, Lonnemann G: Plasma C-reactive protein is linked to backfiltration associated interleukin-6 production. ASAIO J 44:M415-M417, 1998
42. Ross R: Atherosclerosis - an inflammatory disease. N Engl J Med 340:115-126, 1999
43. Bistrian BR: Role of the systemic inflammatory response syndrome in the development of protein-calorie malnutrition in ESRD. Am J Kidney Dis 32:S113-S117, 1998
44. Caglar K, Hakim RM, Ikizler TA: Approaches to the reversal of malnutrition, inflammation, and atherosclerosis in end-stage renal disease. Nutr Rev 60:378-387, 2002
45. Dinarello CA, Roubenoff RA: Mechanisms of loss of lean body mass in patients on chronic dialysis. Blood Purif 14:388-394, 1996
46. Flores EA, Bistrian BR, Pomposelli JJ, Dinarello CA, Blackburn GL, Istfan NW: Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1. J Clin Invest 83:1614-1622, 1989
47. Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys MH, Kopple JD: Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr 80:299-307, 2004
48. Cano NJ, Roth H, Aparicio M, Azar R, Canaud B, Chauveau P, Combe C, Fouque D, Laville M, Leverve XM: Malnutrition in hemodialysis diabetic patients: evaluation and prognostic influence. Kidney Int 62:593-601, 2002
49. Flakoll PJ, Carlson M, Cherrington AC: Physiological action of insulin. In: Leroith DTS, Olefsky J (eds). Diabetes Mellitus: A Fundamental and Clinical Text, 2nd edn. Philadelphia, PA: Williams & Wilkins, 2000:148-161
50. Du J, Hu Z, Mitch WE. Molecular mechanisms activating muscle protein degradation in chronic kidney disease and other catabolic conditions. Eur J Clin Invest 35:157-163, 2005
51. Nair KS, Halliday D, Matthews DE, Welle SL: Hyperglucagonemia during insulin deficiency accelerates protein catabolism. Am J Physiol Endocrinol Metab 253:E208-E213, 1987
52. Charlton MR, Nair KS. Role of hyperglucagonemia in catabolism associated with type 1 diabetes: effects on leucine metabolism and the resting metabolic rate. Diabetes 47:1748-1756, 1998
53. Charlton M, Nair KS. Protein metabolism in insulin-dependent diabetes mellitus. J Nutr 128:323S-372S, 1998
54. Denne SC, Brechtel G, Johnson A, Liechty EA, Baron AD: Skeletal muscle proteolysis is reduced in noninsulin-dependent diabetes mellitus and is unaltered by euglycemic hyperinsulinemia or intensive insulin therapy. J Clin Endocrinol Metab 80:2371-2377, 1995
55. Biolo G, Inchiostro S, Tiengo A, Tessari P: Regulation of postprandial whole-body proteolysis in insulin-deprived IDDM. Diabetes 44:203-209, 1995
56. Luzi L, Petrides AS, De Fronzo RA. Different sensitivity of glucose and amino acid metabolism to insulin in NIDDM. Diabetes 42:1868-1877, 1993
57. Pupim LB, Flakoll PJ, Majchrzak KM, Aftab Guy DL, Stenvinkel P, Ikizler TA: Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus. Kidney Int 68:1857-1865, 2005
58. Pupim LB, Heimburger O, Qureshi AR, Ikizler TA, Stenvinkel P: Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus. Kidney Int 68:2368-2374, 2005
59. DeFronzo RA, Alvestrand A, Smith D, Hendler R, Hendler E, Wahren J: Insulin resistance in uremia. J Clin Invest 67:563-568, 1981
60. Price SR, Du JD, Bailey JL, Mitch WE: Molecular mechanisms regulating protein turnover in muscle. Am J Kidney Dis 37:S112-S114, 2001
61. Lee SW, Dai G, Hu Z, Wang X, Du J, Mitch WE: Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase. J Am Soc Nephrol 15:1537-1545, 2004
62. Price SR, Bailey JL, Wang X, Jurkovitz C, England BK, Ding X, Phillips LS, Mitch WE: Muscle wasting in insulin openic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription. J Clin Invest 98:1703-1708, 1996
63. Lim VS, Yarasheski KE, Crowley JR, Fangman J, Flanigan M: Insulin is protein-anabolic in chronic renal failure patients. J Am Soc Nephrol 14:2297-2304, 2003
64. Kasiske BL, Lakatua JD, Ma JZ, Louis TA: A meta-analysis of the effects of dietary protein restriction on the rate of decline in renal function. Am J Kidney Dis 31:954-961, 1998
65. Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V, Whelton PK, He J: The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med 140:167-174, 2004
66. Garibotto G, Sofia A, Canepa A, Saffioti S, Sacco P, Sala M, Dertenois L, Pastorino N, Deferrari G, Russo R: Acute effects of peritoneal dialysis with dialysates containing dextrose or dextrose and amino acids on muscle protein turnover in patients with chronic renal failure. J Am Soc Nephrol 12:557-567, 2001
67. Jones M, Hagen T, Boyle CA, Vonesh E, Hamburger R, Charytan C, Sandroni S, Bernard D, Piraino B, Schreiber M, Gehr T, Fein P, Friedlander M, Burkart J, Ross D, Zimmerman S, Swartz R, Knight T, Kraus A Jr, McDonald L, Hartnett M, Weaver M, Martis L, Moran J: Treatment of malnutrition with 1.1% amino acid peritoneal dialysis solution: results of a multicenter outpatient study. Am J Kidney Dis 32:761-769, 1998
68. Tjiong HL, van den Berg JW, Wattimena JL, Rietveld T, van Dijk LJ, van der Wiel AM, van Egmond AM, Fieren MW, Swart R: Dialysate as food: combined amino acid and glucose dialysate improves protein anabolism in renal failure patients on automated peritoneal dialysis. J Am Soc Nephrol 16:1486-1493, 2005
69. Beddhu S, Pappas LM, Ramkumar N, Samore M: Effects of body size and body composition on survival in hemodialysis patients. J Am Soc Nephrol 14:2366-2372, 2003
70. Kalantar-Zadeh K, Kuwae N, Wu DY, Shantouf RS, Fouque D, Anker SD, Block G, Kopple JD: Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patients. Am J Clin Nutr 83:202-210, 2006
71. Kopple JD, Zhu X, Lew NL, Lowrie EG: Body weight-for-height relationships predict mortality in maintenance hemodialysis patients. Kidney Int 56:1136-1148, 1999
72. Kalantar-Zadeh K, Kopple JD, Kilpatrick RD, McAllister CJ, Shinaberger CS, Gjertson DW, Greenland S: Association of morbid obesity and weight change over time with cardiovascular survival in hemodialysis population. Am J Kidney Dis 46:489-500, 2005