Clinical measurement of thrombin generation by calibrated automated thrombography requires contact factor inhibition

Journal of Thrombosis and Haemostasis

Volumn 2, Issue 11, 2004, Pages 1954-1959

  Luddington, Roger ^a   Baglin, T ^a  

^a CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Contact factor inhibition; Corn trypsin inhibitor; Thrombin generation; Tissue factor

Indexed keywords

THROMBIN; THROMBOPLASTIN; TRYPSIN INHIBITOR;

ADULT; AGED; ARTICLE; AUTOMATION; BLOOD ANALYSIS; BLOOD CLOTTING; BLOOD CLOTTING TEST; BLOOD SAMPLING; CALIBRATION; CLINICAL ARTICLE; CLINICAL PRACTICE; DIAGNOSTIC TEST; FEMALE; HEMOPHILIA A; HEMOPHILIA B; HUMAN; IN VITRO STUDY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOPHILIA; THROMBOSIS;

ADULT; AGED; AGED, 80 AND OVER; AUTOMATION; BLOOD COAGULATION TESTS; CALIBRATION; CLINICAL LABORATORY TECHNIQUES; HEMOPHILIA A; HUMANS; MIDDLE AGED; PLANT PROTEINS; REPRODUCIBILITY OF RESULTS; THROMBIN; THROMBOPHILIA; THROMBOPLASTIN;

EID: 13244264708     PISSN: 15387933     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2004.00964.x     Document Type: Article

References (22)

1. Hemker H, Beguin S. Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemost 1995; 74: 134-8.
2. Butenas S, van't Veer C, Mann K. 'Normal' thrombin generation. Blood 1999; 94: 2169-78.
3. Hemker H, Beguin S. Phenotyping the clotting system. Thromb Haemost 2000; 84: 747-51.
4. Mannucci P. The measurement of multifactorial thrombophilia. Thromb Haemost 2002; 88: 1-2.
5. Mann K, Brummel K, Butenas S. What is all that thrombin for? J Thromb Haemost 2003; 1: 1504-14.
6. Hemker H, Willems G, Beguin S. A computer assisted method to obtain the prothrombin activation velocity in whole plasma independent of thrombin decay processes. Thromb Haemost 1986; 56: 9-17.
7. Hemker H, Wielders S, Kessels H, Beguin S. Continuous registration of thrombin generation in plasma, its use for the determination of the thrombin potential. Thromb Haemost 1993; 70 617-24.
8. Rand M, Lock J, van't Veer C, Gaffney D, Mann K. Blood clotting in minimally altered whole blood. Blood 1996; 88: 3422-45.
9. Hemker H, Giesen P, Al Dieri R et al. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003; 33: 4-15.
10. Falls L, Furie B, Furie BC. Role of phosphatidylethanolamine in assembly and function of the factor Ixa-factor VIIIa complex on membrane surfaces. Biochemistry 2000; 39: 1321-22.
11. Hemker H, Giesen P, Ramjee M, Wagenvoord R, Beguin S. The thrombogram: monitoring thrombin generation in platelet-rich plasma. Thromb Haemost 2000; 83: 589-92.
12. Josso F, Prou-Wartelle O. Interaction of tissue factor and factor VII at the earliest phase of coagulation. Thromb Diath Haemorrh 1965; 17: 35-44.
13. Osterud B, Rapaport S. Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation. Proc Natl Acad Sci, USA 1977; 74 5260-4.
14. Gailani D, Broze G. Factor XI activation in a revised model of blood coagulation. Science 1991; 253: 909-12.
15. Brummel K, Paradis S, Butenas S, Mann K. Thrombin functions during tissue factor-induced blood coagulation. Blood 2002; 100 148-52.
16. Silverberg M, Dunn J, Garen L, Kaplan A. Autoactivation of human Hageman factor. Demonstration utilizing a synthetic substrate. J Biol Chem 1980; 255: 7281-6.
17. Hong J, Larsson A, Ekdahl K, Elgue G, Larsson R, Nilsson B. Contact between a polymer and whole blood: sequence of events leading to thrombin generation. J Lab Clin Med 2001; 138: 139-45.
18. Hojima Y, Pierce J, Pisano J. Hageman factor fragment inhibitor in corn seeds: purification and characterisation. Thromb Res 1980; 20: 149-62.
19. Schneider D, Tracy P, Mann K, Sobel B. Differential effects of anti-coagulants on the activation of platelets ex vivo. Circulation 1997; 96: 2877-83.
20. Cawthern K, van't Veer C, Lock J, DiLorenzo M, Branda R, Mann K. Blood coagulation in hemophilia A and hemophilia C. Blood 1998; 91: 4581-92.
21. Kumar R, Beguin S, Hemker HC. The influence of fibrinogen and fibrin on thrombin generation - evidence for feedback activation of the clotting system by clot bound thrombin. Thromb Haemost 1994; 72 713-21.
22. Becker D, Fredenburgh J, Stafford A, Weitz J. Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II. J Biol Chem 1999; 274: 6226-33.