CD4+CD25high regulatory T cells reduce T cell transendothelial migration in cancer patients

European Journal of Immunology

Volumn 37, Issue 1, 2007, Pages 282-291

  Enarsson, Karin ^a   Lundin, B Samuel ^a   Johnsson, Erik ^b   Brezicka, Thomas ^b   Quiding Järbrink, Marianne ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cell migration; Immune evasion; Mucosal immunity; Regulatory T cells; Tumor immunology

Indexed keywords

CHEMOKINE; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA; INTERLEUKIN 2 RECEPTOR ALPHA;

ADULT; AGED; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ADHESION; CELL INTERACTION; COLON CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; LEUKOCYTE MIGRATION INHIBITION; LUNG CANCER; LYMPHOCYTE MIGRATION; MAJOR CLINICAL STUDY; MALE; MUCOSAL IMMUNITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STOMACH CANCER; T CELL DEPLETION; TUMOR IMMUNOLOGY; BIOSYNTHESIS; CELL MOTION; COLON TUMOR; CONTACT INHIBITION; CYTOLOGY; IMMUNOLOGY; LEUKOCYTE MIGRATION INHIBITION TEST; LUNG NON SMALL CELL CANCER; LUNG TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; STOMACH TUMOR; VASCULAR ENDOTHELIUM;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION; CELL MIGRATION INHIBITION; CELL MOVEMENT; COLONIC NEOPLASMS; CONTACT INHIBITION; ENDOTHELIUM, VASCULAR; FEMALE; HELICOBACTER PYLORI; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LUNG NEOPLASMS; MALE; MIDDLE AGED; STOMACH NEOPLASMS; T-LYMPHOCYTES, REGULATORY;

EID: 33846381676     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636183     Document Type: Article

References (33)

1. Nagorsen, D., Scheibenbogen, C., Marincola, F. M., Letsch, A. and Keilholz, U., Natural Tce)l immunity against cancer. Clin. Cancer Res. 2003. 9: 4296-4303.
2. Garrido, F. and Algarra, I., MHC antigens and tumor escape from immune surveillance. Adv. Cancer Res. 2001. 83: 117-158.
3. Croce, M. V., Colussi, A. G., Price, M. R. and Segal-Eiras, A., Expression of tumour associated antigens in normal, benign and malignant human mammary epithelial tissue: A comparative immunohistochemical study. Anticancer Res. 1997. 17: 4287-4292.
4. Enarsson, K., Johnsson, E., Lindholm, C., Lundgren, A., Pan-Hammarstrom, Q., Stromberg, E., Bergin, P. et al., Differential mechanisms for T lymphocyte recruitment in normal and neoplastic human gastric mucosa. Clin. Immunol. 2006. 118: 24-34.
5. high regulatory T cells in Helicobacter pylori-infected patients. Infect. Immun. 2005. 73: 523-531.
6. Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M. et al., Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004. 10: 942-949.
7. Wolf, A. M., Wolf, D., Steurer, M., Gastl, G., Gunsilius, E. and Grubeck-Loebenstein, B., Increase of regulatory T cells in the peripheral blood of cancer patients. Clin. Cancer Res. 2003. 9: 606-612.
8. McGuirk, P. and Mills, K. H., Pathogen-specific regulatory T cells provokea shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol. 2002. 23: 450-455.
9. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M., Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoinumme diseases. J. Immunol. 1995. 155: 1151-1164.
10. high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect. Immun. 2003. 71: 1755-1762.
11. Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K. et al., Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 2001. 345: 784-789.
12. Enarsson, K., Brisslert, M., Backert, S. and Quiding-Jarbrink, M., Helicobacter pylori induces transendothelial migration of activated memory T cells. Infect. Immun. 2005. 73: 761-769.
13. + T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 2003. 197: 111-119.
14. Zhang, K., Baeckstrom, D., Brevinge, H. and Hansson, G. C., Comparison of sialyl-Lewis A-carrying CD43 and MUC1 mucins secreted from a colon carcinoma cell line for E-selectin binding and inhibition of leukocyte adhesion. Tumour Biol. 1997 18: 175-187.
15. Alexiou, D., Karayiannakis, A. J., Syrigos, K. N., Zbar, A., Sekara, E., Michail, P., Rosenberg, T. and Diamantis, T., Clinical significance of serum levels of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in gastric cancer patients. Am. J. Gastroenterol. 2003. 98: 478-485.
16. Kunkel, E. J., Campbell, J. J., Haraldsen, G., Pan, J., Boisvert, J., Roberts, A. I., Ebert, E. C. et al., Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J. Exp. Med. 2000. 192: 761-768.
17. Enarsson, K., Lundgren, A., Kindlund, B., Hermansson, M., Roncador, G., Banham, A. H., Lundin, B. S. and Quiding-Jarbrink, M., Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori-infection and gastric adenocarcinoma. Clin. Immunol. 2006, in press.
18. Nakamura, K., Kitani, A. and Strober, W., Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 2001. 194: 629-644.
19. + regulatory T cells cure murine colitis: The role of IL-10, TGF-beta, and CTLA4. J. Immunol. 2003. 171: 5012-5017
20. Hung, K., Hayashi, R., Lafond-Walker, A., Lowenstein, C., Pardoll, D. and Levitsky, H., The central role of CD4(+) T cells in the antitumor immune response. J. Exp. Med. 1998. 188: 2357-2368.
21. + Tcells: Efficacy is limited by migration away from the site and induction of nonresponsiveness. J. Immunol. 1999. 162: 2858-2866.
22. Barbieri, C., Fujisawa, M. M., Yasuda, C. L., Metze, I. L., Oliveira, E. C., Santos, L. M., Lopes, L. R. and Andreollo, N. A., Effect of surgical treatment on the cellular immune response of gastric cancer patients. Braz. J. Med. Biol. Res. 2003. 36: 339-345.
23. Aosasa, S., Ono, S., Mochizuki, H., Tsujimoto, H., Osada, S., Takayama, E., Seki, S. and Hiraide, H., Activation of monocytes and endothelial cells depends on the severity of surgical stress. World J. Surg. 2000. 24: 10-16.
24. + Tcells. J. Immunol. 1999. 162: 696-703.
25. Kawai, T., Seki, M., Watanabe, H., Eastcott, J. W., Smith, D. J. and Taubman, M. A., T(h)l transmigration anergy: A new concept of endothelial cell-T cell regulatory interaction. Int. Immunol. 2000. 12: 937-948.
26. + Tcell responses. J. Exp. Med. 2003. 198: 889-901.
27. Caramalho, L, Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M. and Demengeot, J., Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 2003. 197: 403-411.
28. Burdelya, L., Kujawski, M., Niu, G., Zhong, B., Wang, T., Zhang, S., Kortylewski, M. et al., Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects. J. Immunol. 2005. 174: 3925-3931.
29. Marincola, F. M., Jaffee, E. M., Hicklin, D. J. and Ferrone, S., Escape of human solid tumors from T-cell recognition: Molecular mechanisms and functional significance. Adv. Immunol. 2000. 74: 181-273.
30. Enk, A. and Mahnke, K., In vivo function and manipulation of regulatory T cells. Keystone Symposia: Regulatory/Suppressor T cells 2004 Abstr. 037.
31. Mattsson, A., Tinnert, A., Hamlet, A., Lonroth, H., Bolin, I., and Svennerholm, A. M., Specific antibodies in sera and gastric aspirates of symptomatic and asymptomatic Helicobacter pylori-infected subjects. Clin. Diagn. Lab. Immunol. 1998. 5: 288-293.
32. Innocenti, M., Svermerholm, A. M. and Quiding-Jarbrink, M., Helicobacter pylori lipopolysaccharides preferentially induce CXC chemokine production in human monocytes. Infect. Immun. 2001. 69: 3800-3808.
33. Hamlet, A., Thoreson, A. C., Nilsson, O., Svermerholm, A. M. and Olbe, L., Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers. Gastroenterology 1999. 116: 259-268.