Runx2 is involved in regulating osterix promoter activity and gene expression

Progress in Biochemistry and Biophysics

Volumn 33, Issue 10, 2006, Pages 957-964

  Sun, Dong Mei ^a   Liu, Zhong Bo ^a   Zhao, Yan ^a   Gong, Zhen Wei ^a   Li, Dan ^a   Wang, Xi Yuan ^a   Zeng, Xian Lu ^a   Liu, Wen Guang ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

Author keywords

Gene expression; Osterix; Regulation; Runx2

Indexed keywords

EID: 33846329463     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Aubin J E, Triffitt J T. Mesenchymal stem cells and osteoblast differentiation. In: Bilezikian J P, eds. Principles of Bone Biology. London: Academic Press, 2002. 59-81
2. Yamaguchi A, Komori T, Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev, 2000, 21 (4): 393-411
3. Komori T, Yagi H, Nomura S, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell, 1997, 89 (5): 755-764
4. Otto F, Thornell A P, Crompton T, et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell, 1997, 89 (5): 765-771
5. Mundlos S, Otto F, Mundlos C, et al. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell, 1997, 89 (5): 773-779
6. Ducy P, Zhang R, Geoffroy V, et al. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell, 1997, 89 (5): 747-754
7. Liu W, Toyosawa S, Furuichi T, et al. Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol, 2001, 155 (1): 157-166
8. Nakashima K, Zhou X, Kunkel G, et al. The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation. Cell, 2002, 108 (1): 17-29
9. Liu W G, Wang H Z, Zeng X L. Prog Biochem Biophy, 2003, 30 (1): 27~31
10. Liu R, Liu H, Chen X, et al. Regulation of CSF1 promoter by the SWI/SNF-like BAF complex. Cell, 2001, 106 (3): 309-318
11. Milona M-A, Gough J E, Edgar A J. Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. Genomics, 2003, 4 (1): 43-53
12. Wang S W, Speck N A. Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers. Mol Cell Biol, 1992, 12 (1): 89-102
13. Meyers S, Downing J R, Hiebert S W. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol, 1993, 13 (10): 6336-6345
14. Lu X, Gilbert L, He X, et al. Transcriptional regulation of the Osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NFkappaB pathways. J Biol Chem, 2005, 281 (10): 6297-6306
15. Rossert J, Eberspaecher H, de Crombrugghe B. Separate cis-acting DNA elements of the mouse pro-alpha 1 (I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J Cell Biol, 1995, 129 (5): 1421-1432
16. de Crombrugghe B, Lefebvre V, Nakashima K. Regulatory mechanisms in the pathways of cartilage and bone formation. Curr Opin Cell Biol, 2001, 13 (6): 721-727
17. Komori T. Runx2, a multifunctional transcription factor in skeletal development. J Cell Biochem, 2002, 87 (1): 1-8
18. Komori T. Regulation of skeletal development by the Runx family of transcription factors. J Cell Biochem, 2005, 95 (3): 445-453
19. Lee M H, Kwon T G, Park H S, et al. BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Biochem Biophys Res Commun, 2003, 309 (3): 689-694
20. Harada H, Tagashira S, Fujiwara M, et al. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem, 1999, 274 (11): 6972-6978
21. Xiao Z S, Hjemeland A B, Quarles L D. Selective deficiency of the "bone related" Runx2-II unexpectedly preserves Osteoblast-mediated skeletogenesis. J Biol Chem, 2004, 279 (19): 20307-20313
22. Hirata K, Tsukazaki T, Kadowaki A, et al. Transplantation of skin fibroblasts expressing BMP-2 promotes bone repair more effectively than those expressing Runx2. Bone, 2003, 32 (1): 502-512