Crosstalk of sterol-dependent and non-sterol-dependent signaling in human monocytes after in vitro addition of LDL

Cell Biochemistry and Function

Volumn 25, Issue 1, 2007, Pages 55-62

  Seres, Ildikó ^a   Fóris, Gabriella ^a   Kovács, Éva ^a   Páll, Dénes ^a   Varga, Zsuzsa ^a   Balogh, Zoltán ^a   Paragh, György ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Ca2+ signal; Cholesterol synthesis; Human monocytes; Inositol trisphosphate; LDL receptor; Protein kinase C

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL TRISPHOSPHATE; IODINE 125; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; STEROL; VERAPAMIL;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL MEMBRANE TRANSPORT; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MONOCYTE; PRIORITY JOURNAL;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; CALCIUM SIGNALING; CELLS, CULTURED; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; MALE; MONOCYTES; PERTUSSIS TOXIN; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RECEPTORS, LDL; STEROLS;

EID: 33846324762     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1346     Document Type: Article

References (30)

1. Goldstein JL, Brown MS. Regulation of mevalonate pathway. Nature 1990; 343: 425-430.
2. Brown MS, Goldstein JL. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth). J Lipid Res 1980; 21: 505-517.
3. Hobbs HH, Brown MS, Goldstein JL. Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum Mutat 1992; 1: 445-466.
4. Berridge MJ. J Inositol triphosphate and diacyl glycerol as second messengers. Biochem J 1984; 220: 345-360.
5. 2+] in cultured rat mesangial cells. J Invest Med 1996; 44: 556-560.
6. Tasaki H, Ymashita K, Nakashima Y, Kuroiwa A, Tulenko TN. Increase in intracellular calcium ion in smooth muscle cells induced by low density lipoprotein. Gerontology 1994; 40 (Suppl): 23-28.
7. Pedreno J, Hurt-Camejo E, Wilkund O, Badimin L, Masana L. Low densitiy lipoprotein (LDL) bind to a G-protein coupled receptor in human platelets. Evidence that the proaggregatory effect induced by LDL is modulated by down-regulation of binding sites and desensitization of its mediated signaling. Atherosclerosis 2001; 155: 99-112.
8. Block LH, Buhler FR. Atherosclerosis, cell motility, calcium, and calcium-channel blockers. J Cardiovasc Pharmacol 1992; 19 (Suppl): S1-S3.
9. Mehta KD, Radominska-Pandya A, Kapoor GS, Dave B, Atkins BA. Critical role of triacylglycerol- and phospholipid-regulated protein kinase C epsilon in induction of low-density lipoprotein receptor transcription in response to depletion of cholesterol. Mol Cell Biol 2002; 22: 3783-3793.
10. Fóris G, Paragh G, Dezso B, Keresztes T, Balogh Z, Szabó J. Altered post receptor signal transduction of formyl-Met-Leu-Phe receptors in polymorphonuclear leukocytes of patients with non-insulin-dependent diabetes mellitus. Clin Immunol Immunopathol 1998; 86: 95-101.
11. Paragh G, Kovács E, Seres I, Keresztes T, Balogh Z, Szabó J, Teichmann F, Fóris G. Altered signal pathway in granulocytes from patients with hypercholesterolemia. J Lipid Res 1999; 40: 1728-1733.
12. Paragh G, Szabó J, Kovács E, Keresztes T, Karpati I, Balogh Z, Pall D, Fóris G. Altered signal pathway in angiotensin II-stimulated neutrophils of patients with hypercholesterolaemia. Cell Signalling 2002; 14: 787-792.
13. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. J Clin Lab Invest Suppl 1968; 98: 77-108.
14. Wahl LM, Katona IM, Wilder RL, Winter CC, Haraoui B, Scher I. Isolation of human mononuclear cell subsets by counterflow centrifugal elutriation (CCE). I. Characterization of B-lymphocyte-, and monocyte-enriched fractions by flow cytometric analysis. Cell Immunol 1984; 85: 373-383.
15. Cornwell DG, Kruger FA, Hamui GJ, Brown BJ. Studies on the characterization of human serum lipoproteins separated by ultracentrifugation in density gradiens. Am J Chem Nutr 1961; 9: 24-53.
16. Szondi E, Mezey Z, Füst G, Székely J, Gerõ S. Serial measurement of circulating immune complexes in myocardial infarction. Br Heart J 1981; 46: 93-97.
17. Shaymann JA, BeMeut DM. The separation of myoinositol phosphates by ion-pair chromatography. Biochem Biophys Res Commun 1988; 151: 114-122.
18. Thomas AP, Delaville F. Use of Florescent indicators for Measurements of cytosolic free calcium in cell populations and single cells. In Cellular Calcium. A Practical Approach McCormach J, Cobbold PH (eds). Oxford University Press: Oxford, 1990; pp. 39-41.
19. Bell RM, Hannun Y, Loomish C. Mixed micelle assay of protein kinase C. Methods Enzymol 1986; 124: 353-359.
20. Sheperd J, Bedford DK, Morgan HG. Radioiodination of human low density lipoprotein: A comparison of four methods. Clin Chim Acta 1976; 66: 97-109.
21. Goldstein JL, Brown MS. Binding and degradation of low density lipoproteins by cultured huamn fibroblast. J Biol Chem 1974; 249: 5153-5162.
22. McNamara DJ, Boch CA, Botha A, Mendelsohn D. Sterol synthesis in vitro in freshly isolated blood mononuclear leukocytes from familial hypercholesterolemic patients treated with probucol. Biochem Biophys Acta 1985; 833: 412-419.
23. Nohturfft A, Brown MS, Goldtsein JL. Topology of SREBP cleavage-activating protein, a polytopic membrane protein with sterol-sensing domain. J Biol Chem 1998; 273: 17243-17250.
24. Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I. 2001. SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev 2001; 15: 1206-1216.
25. Sakai J, Nohturfft A, Goldstein JL, Brown MS. 1997. Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. J Biol Chem 1997; 273: 5785-5793.
26. Brown MS, Goldstein JL. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 2000; 89: 331-340.
27. Gimpl G, Burger K, Fahrenholz F. A closer look at the cholesterol sensor. Trends Biochem Sci 2002; 27: 596-599.
28. Ruan XZ, Varghese Z, Powis SH, Moorhead JF. Dysregulation of LDL receptor under the influence of inflammatory cytokines: a new pathway for foam cell formation. Kidney Int 2001; 60: 1716-1725.
29. Mondola P, Seru R, Santillo M, Damiano S, Bifulco M, Laezza C, Formisano P, Rotilio G, Ciriolo MR. Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells. Biochem Biophys Res Commun 2002; 295: 603-609.
30. Paragh G, Nagy TJ, Szondy E, Foris G, Leovey A. Immunomodulating effect of low density lipoprotein on human monocytes. Clin Exp Immunol 1986; 64: 665-672.