Low-density lipoprotein (LDL) binds to a G-protein coupled receptor in human platelets: Evidence that the proaggregatory effect induced by LDL is modulated by down-regulation of binding sites and desensitization of its mediated signaling

Atherosclerosis

Volumn 155, Issue 1, 2001, Pages 99-112

  Pedreo, Javier ^a   Hurt Camejo, Eva ^b   Wiklund, Olov ^b   Badimón, Lina ^c   Masana, Lluis ^a  

^a FACULTAT DE MEDICINA I CIÈNCIES DE LA SALUT   (Spain)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Desensitization; Down regulation; G proteins; LDL; Platelets; Signaling

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BISINDOLYLMALEIMIDE; CALCIUM ION; CHOLERA TOXIN; CHYLOMICRON; CONCANAVALIN A; G PROTEIN COUPLED RECEPTOR; HEPARIN; HIGH DENSITY LIPOPROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; LOW DENSITY LIPOPROTEIN; PERTUSSIS TOXIN; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; STAUROSPORINE; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; BINDING SITE; CALCIUM MOBILIZATION; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DOSE TIME EFFECT RELATION; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; THROMBOGENICITY;

BINDING SITES; BLOOD PLATELETS; CALCIUM; CHOLERA TOXIN; CYTOSOL; DOWN-REGULATION; GTP-BINDING PROTEIN REGULATORS; GTP-BINDING PROTEINS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; LIPOPROTEINS; LIPOPROTEINS, IDL; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; PERTUSSIS TOXIN; PLATELET AGGREGATION; PROTEIN KINASE C; RECEPTORS, CELL SURFACE; RECEPTORS, LDL; VIRULENCE FACTORS, BORDETELLA;

EID: 0035109607     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(00)00545-1     Document Type: Article

References (57)

1. The pathogenesis of coronary artery disease and the acute coronary syndromes
2. The pathogenesis of coronary artery disease and the acute coronary syndromes
3. Platelet function in hyperlipoproteinemia
4. Enhanced in vivo platelet release reaction and malondialdehyde formation in patients with hyperlipidemia
5. The effect of human plasma on platelet function in familial hypercholesterolemia
6. LDLs increase the exposure of fibrinogen binding sites on platelet and secretion of dense granules
7. Platelets and the lipoproteins: Native, modified and platelet modified lipoproteins
8. Effect of cholesterol on production of thromboxane B2 by platelet in vitro
9. Platelet function and platelet lipid composition in dyslipoproteinemias
10. LDL binding to human platelets. Role of charge and specific amino acids
11. Study of LDL interaction with platelets by flow cytofluorimetry
12. Specific binding sites on human blood platelets for plasma lipoproteins
13. LDL binding sites on platelets differ from the 'classical' receptor of nucleated cells
14. Platelet LDL receptor recognizes with the same apparent affinity both oxidized and native LDL. Evidence that the receptor-ligand complexes are not internalized
15. Purification and identification of the lipoprotein-binding proteins from human blood platelet membrane
16. Proteolytic susceptibility of platelet LDL receptor
17. 3 (GPIIb-IIIa) is not implicated in the binding of LDL to intact resting platelets
18. 3-mediated signaling
19. CD36 is a receptor for oxidized low density lipoproteins
20. CD36 is a specific receptor for native and modified low-density lipoproteins
21. Intracellular mechanisms in the activation of human platelets by low-density lipoproteins
22. Low density lipoprotein causes general cellular activation with increased phosphatidylinositol turnover and lipoprotein catabolism
23. Low-density lipoproteins increase intracellular calcium in aequorin-loaded platelets
24. 2+-mobilizing activity of low density lipoproteins
25. 2+ and membrane dynamics in patients with primary hypercholesterolemia. Effects of pravastatin
26. Turning off the signal: Desensitization of β-adrenergic receptor function
27. 2-adrenergic receptors
28. 1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: Possible implications for negative feedback regulation of inositol phospholipid hydrolysis
29. Regulation of adrenergic receptors
30. Prostacyclin receptor desensitization is a reversible phenomenon in human platelets
31. Protein kinase C-dependent desensitization of HDL3-activated phospholipase C in human platelets
32. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
33. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding
34. Mildly oxidized LDL induces platelet aggregation through activation of phospholipase A2
35. Low density lipoprotein binding to human platelets: Role of charge and of specific amino acids
36. Detection of a protein in human platelet membranes which binds low-density lipoproteins
37. Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetracholoro-3,6-diphenylglycoluril (iodogen)
38. In vitro effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on non-hepatic LDL receptor activity: Evidence of lack of stimulatory effect of pravastatin
39. Measurement of platelet cytoplasmatic ionized calcium concentration with aequorin and fluorescent indicators
40. 2+ concentration and dense tubular system in human platelets
41. 2+ indicators with greatly improved fluorescence properties
42. Mechanisms for regulating platelet high density lipoprotein type 3 binding sites. Evidence that binding sites are down-regulated by a protein kinase C-dependent mechanism
43. The attractions of proteins for small molecules and ions
44. Analysis of radioligand binding experiments: A collection of computer programs for IBM PC
45. 50) of an enzymatic reaction
46. Neurotransmitter, hormone, or drug receptor binding methods
47. 2-adrenergic receptor desensitization: Delineation with specific inhibitors
48. Low density lipoprotein phosphorylates the focal adhesion-associated kinase p125(FAK) in human platelets independent of integrin
49. A role for Pyk2 and Src in linking G protein-coupled receptors with MAP kinase activation
50. Protein tyrosine kinase Pyk2 involved in calcium-induced regulation of ion channel and MAP kinase functions
51. Signaling through G proteins in platelets: To the integrins and beyond
52. Outside-in integrin signal transduction
53. Phosphatidylcholine breakdown in HDL3 stimulated platelets
54. Pertussis toxin sensitive G-protein coupling of HDL receptor to PLC in platelets
55. HDL3-mediated inhibition of thrombin-induced platelet aggregation and fibrinogen binding occurs via decreased production of phosphoinositide-derived second messengers 1,2-diacylglycerol and inositol 1,4,5-tris-phosphate
56. Platelet deposition at high shear rates is enhanced by high plasma cholesterol levels. In vivo study in the rabbit model
57. Human typeII hyperlipoproteinemia enhances platelet-collagen adhesion in flowing nonanticoagulated blood