Analysis of the young and elderly variable gene repertoire in response to pneumococcal polysaccharides using a reconstituted SCID mouse model

Vaccine

Volumn 24, Issue 49-50, 2006, Pages 7159-7166

  Shriner, Anne K ^a   Smithson, S Louise ^a   Rabquer, Bradley ^a   Khuder, Sadik ^a   Westerink, M A Julie ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Aging; Cytokines; Gene expression; Pneumococcal polysaccharides

Indexed keywords

PNEUMOCOCCUS VACCINE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CELL ISOLATION; CONTROLLED STUDY; HEAVY CHAIN; HUMAN; IMMUNIZATION; IMMUNOGLOBULIN VARIABLE REGION; LIGHT CHAIN; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCID MOUSE; SEROTYPE; STREPTOCOCCUS INFECTION;

ADULT; AGED; AGING; ANIMALS; B-LYMPHOCYTES; CELL TRANSPLANTATION; CYTOKINES; DNA, COMPLEMENTARY; HUMANS; MICE; MICE, SCID; PNEUMOCOCCAL VACCINES; POLYSACCHARIDES; RNA, MESSENGER; STREPTOCOCCUS PNEUMONIAE;

EID: 33846308870     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2006.06.055     Document Type: Article

References (32)

1. Musher D. Streptococcus pneumoniae. In: Mandell G.L., Bennett J.E., and Dolin R. (Eds). Mandell, Douglass and Bennett's principles and practice of infectious diseases (2004), John Wiley & Sons, New York
2. Musher D. Pneumococcal infections. In: Fauci A.S. (Ed). Harrison's principles of principle of internal medicine (2004), McGraw-Hill, New York
3. Nutori P., and Butler J. Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). Morb Mortal Wkly Rep 46 13 (1997)
4. Shapiro E.D., Berg A.T., Austrian R., et al. The protective efficacy of polyvalent pneumococcal polysaccharide vaccine. N Engl J Med 325 21 (1991) 1453-1460
5. Hirschmann J.V., and Lipsky B.A. The pneumococcal vaccine after 15 years of use. Arch Intern Med 154 4 (1994) 373-377
6. Romero-Steiner S., Musher D.M., Cetron M.S., et al. Reduction in functional antibody activity against Streptococcus pneumoniae in vaccinated elderly individuals highly correlates with decreased IgG antibody avidity. Clin Infect Dis 29 2 (1999) 281-288
7. Ekstrom N., Ahman H., Verho J., et al. Kinetics and avidity of antibodies evoked by heptavalent pneumococcal conjugate vaccines PncCRM and PncOMPC in the Finnish Otitis Media Vaccine Trial. Infect Immun 73 1 (2005) 369-377
8. Usinger W.R., and Lucas A.H. Avidity as a determinant of the protective efficacy of human antibodies to pneumococcal capsular polysaccharides. Infect Immun 67 5 (1999) 2366-2370
9. Lucas A., McLean G., Reason D., O'Connor A., Felton M., and Moulton K. Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide: expression of canonical variable regions and their variants in vaccinated infants. Clin Immunol (Orlando, Fla.) 108 2 (2003) 119
10. L gene repertoire and in specificity. J Immunol 147 8 (1991) 2750-2755
11. Lucas A.H., Azmi F.H., Mink C.M., and Granoff D.M. Age-dependent V region expression in the human antibody response to the Haemophilus influenzae type b polysaccharide. J Immunol 150 (1993) 2056-2061
12. Lucas A.H., Moulton K.D., and Reason D.C. Role of kappa II-A2 light chain CDR-3 junctional residues in human antibody binding to the Haemophilus influenzae type b polysaccharide. J Immunol 161 7 (1998) 3776-3780
13. Adderson E.E., Wilson P.M., Cunningham M.W., and Shackelford P.G. Haemophilus influenzae type b polysaccharides-protein conjugate vaccine elicits a more diverse antibody repertoire in infants than in adults. J Immunol 161 8 (1998) 4177-4182
14. Smithson S.L., Kolibab K., Shriner A.K., Srivastava N., Khuder S., and Westerink M.A. Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults: analysis of the variable light chain repertoire. Infect Immun 73 11 (2005) 7477-7484
15. Kolibab K., Smithson S.L., Rabquer B., Khuder S., and Westerink M.A. Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults: analysis of the variable heavy chain repertoire. Infect Immun 73 11 (2005) 7465-7476
16. Yang X., Stedra J., and Cerny J. Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J Exp Med 183 3 (1996) 959-970
17. Aydar Y., Balogh P., Tew J.G., and Szakal A.K. Follicular dendritic cells in aging, a "bottle-neck" in the humoral immune response. Ageing Res Rev 3 1 (2004) 15-29
18. Chelvarajan R.L., Collins S.M., Van Willigen J.M., and Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol (2005)
19. Jerne N.K. Toward a network theory of the immune system. Ann Immunol 125 (1974) 373-389
20. McNerlan S.E., Rea I.M., and Alexander H.D. A whole blood method for measurement of intracellular TNF-alpha, IFN-gamma and IL-2 expression in stimulated CD3+ lymphocytes: differences between young and elderly subjects. Exp Gerontol 37 2-3 (2002) 227-234
21. Sandmand M., Bruunsgaard H., Kemp K., et al. Is ageing associated with a shift in the balance between type 1 and type 2 cytokines in humans?. Clin Exp Immunol 127 1 (2002) 107-114
22. Hikida M., Nakayama Y., Yamashita Y., Kumazawa Y., Nishikawa S.I., and Ohmori H. Expression of recombination activating genes in germinal center B cells: involvement of interleukin 7 (IL-7) and the IL-7 receptor. J Exp Med 188 2 (1998) 365-372
23. Ohlin M., Danielsson A., Carlsson L.R., and Borrebaeck C.A.K. The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes. Immunology 66 (1989) 485-490
24. Hardy R.R., Hayakawa K., Shimizu M., Yamasaki K., and Kishimoto T. Rheumatoid factor secretion from human Leu-1+ B cells. Science 236 (1987) 81-83
25. Wernette C.M., Frasch C.E., Madore D., et al. Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides. Clin Diagn Lab Immunol 10 4 (2003) 514-519
26. Lucas A.H., Moulton K.D., Tang V.R., and Reason D.C. Combinatorial library cloning of human antibodies to streptococcus pneumoniae capsular polysaccharides: variable region primary structures and evidence for somatic mutation of fab fragments specific for capsular serotypes 6B, 14, and 23F. Infect Immun 69 2 (2001) 853-864
27. Zhou J., Lottenbach K.R., Barenkamp S.J., Lucas A.H., and Reason D.C. Recurrent variable region gene usage and somatic mutation in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae type 23F. Infect Immun 70 8 (2002) 4083-4091
28. Smithson S.L., Srivastava N., Hutchins W.A., and Westerink M.A. Molecular analysis of the heavy chain of antibodies that recognize the capsular polysaccharide of Neisseria meningitidis in hu-PBMC reconstituted SCID mice and in the immunized human donor. Mol Immunol 36 2 (1999) 113-124
29. Bondada S., Wu H.-J., Robertson D.A., and Chelvarajan R.L. Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines. Vaccine 19 4-5 (2001) 557-565
30. Vinuesa C.G., Sze D.M., Cook M.C., et al. Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens. Eur J Immunol 33 2 (2003) 297-305
31. Kruetzmann S., Rosado M.M., Weber H., et al. Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J Exp Med 197 7 (2003) 939-945
32. Ishikawa F., Yasukawa M., Lyons B., et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain (null) mice. Blood 106 5 (2005) 1565-1573