Niaouli oil as enhancer for transdermal permeation of estradiol: Evaluation of gel formulations on hairless rats in vivo

Journal of Drug Delivery Science and Technology

Volumn 16, Issue 6, 2006, Pages 473-476

  Monti, D ^a   Najarro, M ^a   Chetoni, P ^a   Burgalassi, S ^a   Saettone, M F ^a   Boldrini, E ^b,c  

^a UNIVERSITY OF PISA   (Italy)

^b Farmigea SpA   (Italy)

^c Opocrin SpA   (Italy)

Author keywords

Alcoholic gel vehicles; Estradiol; Hairless female rats; Hairless mouse skin; In vitro transdermal delivery; In vivo administration; Niaouli essential oil; Penetration enhancers

Indexed keywords

ESTRADIOL; NIAOULI OIL; TERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BOLUS INJECTION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; FEMALE; GEL; IN VIVO STUDY; NONHUMAN; RAT; SINGLE DRUG DOSE; SKIN PERMEABILITY;

EID: 33846301467     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(06)50090-5     Document Type: Article

References (17)

1. Nelson H.D., Humphrey L.L., Nygren P., Teutsch S.M., Allan J.D. - Postmenopausal hormone replacement therapy. - Scientific Review JAMA, 288, 872-881, 2002.
2. Laufer L.R., Defazio J.L., Lu J.K., Meldrum D.R., Eggena P., Sambhi M.P., Hershaman J.M., Judd H.L. - Estrogen replacement therapy by transdermal estradiol administration. - Am. J. Obstet. Gynecol., 146, 533-40, 1983.
3. Powers M.S., Schenkel L., Darley P.E., Good W.R., Balestra J.C., Place V.A. - Pharmacokinetics and pharmacodynamics of transdermal dosage forms of 17 beta-estradiol: comparison with conventional oral estrogens used for hormone replacement. - Am. J. Obstet. Gynecol., 152, 1099-106, 1985.
4. Selby P., McGarrigle H.H., Peacock M. - Comparison of the effects of oral and transdermal oestradiol administration on oestrogen metabolism, protein synthesis, gonadotrophin release, bone turnover and climacteric symptoms in postmenopausal women. - Clin. Endocrinol. (Oxf)., 30, 241-249, 1989.
5. Crook D. - The metabolic consequences of treating postmenopausal women with non-oral hormone replacement therapy. - Br. J. Obstet. Gynecol., 104, 4-13, 1997.
6. Walters K.A., Brain K.R., Green D.M., James V.J., Watkinson A.C., Sands R.H. - Comparison of the transdermal delivery of estradiol from two gel formulations. - Maturitas, 29, 189-95, 1998.
7. Minkin M.J. - Considerations in the choice of oral vs. transdermal hormone therapy. - J. Reprod. Med., 49, 311-320, 2004.
8. Staren E.D., Omer S. - Hormone replacement therapy in postmenopausal women. - Am. J. Surg., 188, 136-49, 2004.
9. Hope S., Rees M.C.P. - Why do British women start and stop hormone replacement therapy. - J. Br. Menopause Soc., 1, 26-27, 1995.
10. Cheang A., Sitruk-Ware R., Utian W.H. - A risk-benefit appraisal of transdermal estradiol therapy. - Drug Safety, 9, 356-359, 1993.
11. Jarvinen A., Granander M., Laine T., Viitanen A. - Effect of dose on the absorption of estradiol from a transdermal gel. - Maturitas, 35, 51-56, 2000.
12. Paoletti A.M., Pilia I., Nannipieri F., Bigini C., Melis G.B. - Comparison of pharmacokinetic profiles of a 17-β-estradiol gel 0.6 mg/g (Gelestra) with a transdermal delivery system (Estraderm TTS50) in postmenopausal women at steady state. - Maturitas, 40, 203-209, 2001.
13. Monti D., Chetoni P., Burgalassi S., Najarro M., Saettone M. F., Boldrini E. - Effect of different terpene-containing essential oils on permeation of estradiol through hairless mouse skin. - Int. J. Pharm., 237, 209-214, 2002.
14. Monti D., Najarro M., Chetoni P., Burgalassi S., Saettone M.F., Boldrini E. - Vehicle and enhancer effects on transdermal permeation of estradiol from gel formulations. Evaluation in vitro. - J. Drug Deliv. Sci. Technol., 15, 469-473, 2005.
15. Petroff B.K., Mizinga K.M. - Pharmacokinetics of ovarian steroids in Sprague-Dawley rats after acute exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD). - Reprod. Biol., 3, 131-141, 2003.
16. Arellano A., Santoyo S., Martin C., Ygartua P. - Influence of propylene glycol and isopropyl myristate on the in vitro percutaneous penetration of diclofenac sodium from carbopol gels. - Eur. J. Pharm. Sci., 7, 129-135, 1999.
17. Williams A.C., Barry B.W. - Penetration enhancers. - Adv. Drug. Del. Revs., 56, 603-18, 2002.