Maturation of in vitro-generated human islets after transplantation in nude mice

Molecular and Cellular Endocrinology

Volumn 264, Issue 1-2, 2007, Pages 28-34

  Gao, Ru ^a   Ustinov, Jarkko ^a   Korsgren, Olle ^b   Mikkola, Milla ^a   Lundin, Karolina ^a   Otonkoski, Timo ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Islet; Maturation; Neogenesis; Transplantation

Indexed keywords

CELL MARKER; CLUSTERIN; CYTOKERATIN 19; GLUCAGON; HORMONE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL MATURATION; CULTIVATED HUMAN ISLET BUD; EMBRYO; ENDOCRINE CELL; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RODENT; STEM CELL; TISSUE GRAFT;

ANIMALS; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CLUSTERIN; GENE EXPRESSION REGULATION; GLUCAGON; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; KERATIN-19; MICE; MICE, NUDE; RATS; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 33846259373     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2006.10.007     Document Type: Article

References (26)

1. Baeyens L., De Breuck S., Lardon J., Mfopou J.K., Rooman I., and Bouwens L. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 48 (2005) 49-57
2. Blaschuk O., Burdzy K., and Fritz I.B. Purification and characterization of a cell-aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid. J. Biol. Chem. 258 (1983) 7714-7720
3. Bogdani M., Lefebvre V., Buelens N., Bock T., Pipeleers-Marichal M., In't Veld P., and Pipeleers D. Formation of insulin-positive cells in implants of human pancreatic duct cell preparations from young donors. Diabetologia 46 (2003) 830-838
4. Bonner-Weir S., Taneja M., Weir G.C., Tatarkiewicz K., Song K.H., Sharma A., and O'neil J.J. In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 7999-8004
5. Castaing M., Peault B., Basmaciogullari A., Casal I., Czernichow P., and Scharfmann R. Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice. Diabetologia 44 (2001) 2066-2076
6. De Krijger R.R., Aanstoot H.J., Kranenburg G., Reinhard M., Visser W.J., and Bruining G.J. The midgestational human fetal pancreas contains cells coexpressing islet hormones. Dev. Biol. 153 (1992) 368-375
7. Gao R., Ustinov J., Pulkkinen M.A., Lundin K., Korsgren O., and Otonkoski T. Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 52 (2003) 2007-2015
8. Gao R., Ustinov J., Korsgren O., and Otonkoski T. In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells. Diabetologia 48 (2005) 2296-2304
9. Gu D., Lee M.-S., Krahl T., and Sarvetnick N. Transitional cells in the regenerating pancreas. Development 120 (1994) 1873-1881
10. Hao E., Tyrberg B., Itkin-Ansari P., Lakey J.R., Geron I., Monosov E.Z., Barcova M., Mercola M., and Levine F. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat. Med. 12 (2006) 310-316
11. Hayek A., and Beattie G.M. Experimental transplantation of human fetal and adult pancreatic islets. J. Clin. Endocrinol. Metab. 82 (1997) 2471-2475
12. Kim B.M., Han Y.M., Shin Y.J., Min B.H., and Park I.S. Clusterin expression during regeneration of pancreatic islet cells in streptozotocin-induced diabetic rats. Diabetologia 44 (2001) 2192-2202
13. Kim B.M., Kim S.Y., Lee S., Shin Y.J., Min B.H., Bendayan M., and Park I.S. Clusterin induces differentiation of pancreatic duct cells into insulin-secreting cells. Diabetologia 49 (2006) 311-320
14. Min B.H., Jeong S.Y., Kang S.W., Crabo B.G., Foster D.N., Chun B.G., Bendayan M., and Park I.S. Transient expression of clusterin (sulfated glycoprotein-2) during development of rat pancreas. J. Endocrinol. 158 (1998) 43-52
15. Min B.H., Kim B.M., Lee S.H., Kang S.W., Bendayan M., and Park I.S. Clusterin expression in the early process of pancreas regeneration in the pancreatectomized rat. J. Histochem. Cytochem. 51 (2003) 1355-1365
16. Minami K., Okuno M., Miyawaki K., Okumachi A., Ishizaki K., Oyama K., Kawaguchi M., Ishizuka N., Iwanaga T., and Seino S. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 15116-15121
17. Ozmen L., Ekdahl K.N., Elgue G., Larsson R., Korsgren O., and Nilsson B. Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation. Diabetes 51 (2002) 1779-1784
18. Polak M., Bouchareb-Banaei L., Scharfmann R., and Czernichow P. Early pattern of differentiation in the human pancreas. Diabetes 49 (2000) 225-232
19. Ramiya V.K., Maraist M., Arfors K.E., Schatz D.A., Peck A.B., and Cornelius J.G. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells [see comments]. Nat. Med. 6 (2000) 278-282
20. Ricordi C., Lacy P.E., Finke E.H., Olack B.J., and Scharp D.W. Automated method for isolation of human pancreatic islets. Diabetes 37 (1988) 413-420
21. Street C.N., Lakey J.R., Shapiro A.M., Imes S., Rajotte R.V., Ryan E.A., Lyon J.G., Kin T., Avila J., Tsujimura T., and Korbutt G.S. Islet graft assessment in the Edmonton protocol: implications for predicting long-term clinical outcome. Diabetes 53 (2004) 3107-3114
22. Suarez-Pinzon W.L., Lakey J.R., Brand S.J., and Rabinovitch A. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet β-cells from pancreatic duct cells and an increase in functional β-cell mass. J. Clin. Endocrinol. Metab. 90 (2005) 3401-3409
23. Teitelman G., Alpert S., Polak J.M., Martinez A., and Hanahan D. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118 (1993) 1031-1039
24. Tuch B.E. Reversal of diabetes by human fetal pancreas. Transplantation 51 (1991) 557-562
25. Tyrberg B., Eizirik D.L., Hellerström C., Pipeleers D.G., and Andersson A. Human pancreatic β-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro. Endocrinology 137 (1996) 5694-5699
26. Tyrberg B., Ustinov J., Otonkoski T., and Andersson A. Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ. Diabetes 50 (2001) 301-307