-
1
-
-
0036468709
-
ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells
-
Davie N, Haleen SJ, Upton PD, et al. ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells. Am J Respir Crit Care Med 2002;165:398-405.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, pp. 398-405
-
-
Davie, N.1
Haleen, S.J.2
Upton, P.D.3
-
2
-
-
0028800341
-
Effects of separate and combined ETA and ETB blockade on ET-1-induced constriction in perfused rat lungs
-
Sato K, Oka M, Hasunuma K, et al. Effects of separate and combined ETA and ETB blockade on ET-1-induced constriction in perfused rat lungs. Am J Physiol 1995;269:L668-72.
-
(1995)
Am J Physiol
, vol.269
-
-
Sato, K.1
Oka, M.2
Hasunuma, K.3
-
3
-
-
0028181821
-
Endothelin ETA- and ETB-receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles
-
MacLean MR, McCulloch KM, Baird M. Endothelin ETA- and ETB-receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles. J Cardiovasc Pharmacol 1994;23:838-45.
-
(1994)
J Cardiovasc Pharmacol
, vol.23
, pp. 838-845
-
-
MacLean, M.R.1
McCulloch, K.M.2
Baird, M.3
-
4
-
-
20044366257
-
Endothelin antagonism in pulmonary hypertension, heart failure, and beyond
-
Attina T, Camidge R, Newby DE, et al. Endothelin antagonism in pulmonary hypertension, heart failure, and beyond. Heart 2005;91:825-31.
-
(2005)
Heart
, vol.91
, pp. 825-831
-
-
Attina, T.1
Camidge, R.2
Newby, D.E.3
-
5
-
-
0030053456
-
Enhanced coronary vasoconstriction to endothelin-B-receptor activation in experimental congestive heart failure
-
Cannan CR, Burnett JC Jr, Lerman A. Enhanced coronary vasoconstriction to endothelin-B-receptor activation in experimental congestive heart failure. Circulation 1996;93:646-51.
-
(1996)
Circulation
, vol.93
, pp. 646-651
-
-
Cannan, C.R.1
Burnett Jr, J.C.2
Lerman, A.3
-
6
-
-
0028333046
-
Clearance of circulating endothelin-1 by ETB receptors in rats
-
Fukuroda T, Fujikawa T, Ozaki S, et al. Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem Biophys Res Commun 1994;199:1461-5.
-
(1994)
Biochem Biophys Res Commun
, vol.199
, pp. 1461-1465
-
-
Fukuroda, T.1
Fujikawa, T.2
Ozaki, S.3
-
7
-
-
1542514709
-
Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: A comparison of selective and combined endothelin receptor blockade
-
Goddard J, Johnston NR, Hand MF, et al. Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade. Circulation 2004;109:1186- 93.
-
(2004)
Circulation
, vol.109
, pp. 1186-1193
-
-
Goddard, J.1
Johnston, N.R.2
Hand, M.F.3
-
8
-
-
0034816975
-
Endothelin antagonists for chronic heart failure: Do they have a role?
-
Cowburn PJ, Cleland JG. Endothelin antagonists for chronic heart failure: do they have a role? Eur Heart J 2001;22:1772-84.
-
(2001)
Eur Heart J
, vol.22
, pp. 1772-1784
-
-
Cowburn, P.J.1
Cleland, J.G.2
-
9
-
-
0032564374
-
Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure
-
Sutsch G, Kiowski W, Yan XW, et al. Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure. Circulation 1998;98:2262-8.
-
(1998)
Circulation
, vol.98
, pp. 2262-2268
-
-
Sutsch, G.1
Kiowski, W.2
Yan, X.W.3
-
10
-
-
0037137297
-
Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: The Heart Failure ET(A) Receptor Blockade Trial (HEAT)
-
Luscher TF, Enseleit F, Pacher R, et al. Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT). Circulation 2002;106:2666-72.
-
(2002)
Circulation
, vol.106
, pp. 2666-2672
-
-
Luscher, T.F.1
Enseleit, F.2
Pacher, R.3
-
11
-
-
0033510665
-
Update of REACH-1 and MERIT-HF clinical trials in heart failure. Cardio.net Editorial Team
-
Mytona P, Cleland JG. Update of REACH-1 and MERIT-HF clinical trials in heart failure. Cardio.net Editorial Team. Eur J Heart Fail 1999;1:197-200.
-
(1999)
Eur J Heart Fail
, vol.1
, pp. 197-200
-
-
Mytona, P.1
Cleland, J.G.2
-
12
-
-
0036023198
-
Recent heart failure trials of neurohormonal modulation (OVERTURE and ENABLE): Approaching the asymptote of efficacy?
-
Teerlink JR. Recent heart failure trials of neurohormonal modulation (OVERTURE and ENABLE): approaching the asymptote of efficacy? J Cardiac Failure 2002;8:124-7.
-
(2002)
J Cardiac Failure
, vol.8
, pp. 124-127
-
-
Teerlink, J.R.1
-
13
-
-
0345442417
-
Progress in clinical trials: ENCOR (Enrasentan Cooperative Randomized Evaluation)
-
Abrahams W. Progress in clinical trials: ENCOR (Enrasentan Cooperative Randomized Evaluation). Clin Cardiol 2001;24:481-3.
-
(2001)
Clin Cardiol
, vol.24
, pp. 481-483
-
-
Abrahams, W.1
-
14
-
-
3242810591
-
Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): Randomised, double-blind, placebo-controlled trial
-
Anand I, McMurray J, Cohn JN, et al. Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial. Lancet 2004;364:347-54.
-
(2004)
Lancet
, vol.364
, pp. 347-354
-
-
Anand, I.1
McMurray, J.2
Cohn, J.N.3
-
15
-
-
0025913812
-
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
-
The SOLVD Investigators
-
The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991;325:293-302.
-
(1991)
N Engl J Med
, vol.325
, pp. 293-302
-
-
-
16
-
-
8244241095
-
Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure. Second Prospective Randomised Study of Ibopamine on Mortality and Efficacy (PRIME II) Investigators
-
Hampton JR, van Veldhuisen DJ, Kleber FX, et al. Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure. Second Prospective Randomised Study of Ibopamine on Mortality and Efficacy (PRIME II) Investigators. Lancet 1997;349:971-7.
-
(1997)
Lancet
, vol.349
, pp. 971-977
-
-
Hampton, J.R.1
van Veldhuisen, D.J.2
Kleber, F.X.3
-
17
-
-
0029950405
-
Inhibition of myocardial endothelin pathway improves long-term survival in heart failure
-
Sakai S, Miyauchi T, Kobayashi M, et al. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure. Nature 1996;384:353-5.
-
(1996)
Nature
, vol.384
, pp. 353-355
-
-
Sakai, S.1
Miyauchi, T.2
Kobayashi, M.3
-
18
-
-
0030817074
-
Role of endogenous endothelin in chronic heart failure: Effect of long-term treatment with an endothelin antagonist on survival, hemodynamics, and cardiac remodeling
-
Mulder P, Richard V, Derumeaux G, et al. Role of endogenous endothelin in chronic heart failure: effect of long-term treatment with an endothelin antagonist on survival, hemodynamics, and cardiac remodeling. Circulation 1997;96:1976-82.
-
(1997)
Circulation
, vol.96
, pp. 1976-1982
-
-
Mulder, P.1
Richard, V.2
Derumeaux, G.3
-
19
-
-
0242268070
-
Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure
-
Lee DS, Nguyen QT, Lapointe N, et al. Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure. J Cardiac Failure 2003;9:368-74.
-
(2003)
J Cardiac Failure
, vol.9
, pp. 368-374
-
-
Lee, D.S.1
Nguyen, Q.T.2
Lapointe, N.3
-
20
-
-
0035940394
-
Long-term effects of nonselective endothelin A and B receptor antagonism in postinfarction rat: Importance of timing
-
Nguyen QT, Cernacek P, Sirois MG, et al. Long-term effects of nonselective endothelin A and B receptor antagonism in postinfarction rat: importance of timing. Circulation 2001;104:2075-81.
-
(2001)
Circulation
, vol.104
, pp. 2075-2081
-
-
Nguyen, Q.T.1
Cernacek, P.2
Sirois, M.G.3
-
21
-
-
0034932967
-
Nonselective endothelin receptor antagonist initiated soon after the onset of myocardial infarction may deteriorate 24-hour survival
-
Takanashi C, Kagaya Y, Namiuchi S, et al. Nonselective endothelin receptor antagonist initiated soon after the onset of myocardial infarction may deteriorate 24-hour survival. J Cardiovasc Pharmacol 2001;38:29-38.
-
(2001)
J Cardiovasc Pharmacol
, vol.38
, pp. 29-38
-
-
Takanashi, C.1
Kagaya, Y.2
Namiuchi, S.3
-
22
-
-
21044434629
-
Direct comparison of selective endothelin A and non-selective endothelin A/B receptor blockade in chronic heart failure
-
Leslie SJ, Spratt JC, McKee SP, et al. Direct comparison of selective endothelin A and non-selective endothelin A/B receptor blockade in chronic heart failure. Heart 2005;91:914-19.
-
(2005)
Heart
, vol.91
, pp. 914-919
-
-
Leslie, S.J.1
Spratt, J.C.2
McKee, S.P.3
-
23
-
-
0141882923
-
Comparative impact of enalapril, candesartan or metoprolol alone or in combination on ventricular remodelling in patients with congestive heart failure
-
McKelvie RS, Rouleau JL, White M, et al. Comparative impact of enalapril, candesartan or metoprolol alone or in combination on ventricular remodelling in patients with congestive heart failure. Eur Heart J 2003;24:1727-34.
-
(2003)
Eur Heart J
, vol.24
, pp. 1727-1734
-
-
McKelvie, R.S.1
Rouleau, J.L.2
White, M.3
-
24
-
-
11844304145
-
Comparison of selective ET(A) and ET(B) receptor antagonists in patients with chronic heart failure
-
Cowburn PJ, Cleland JG, McDonagh TA, et al. Comparison of selective ET(A) and ET(B) receptor antagonists in patients with chronic heart failure. Eur J Heart Fail 2005;7:37-42.
-
(2005)
Eur J Heart Fail
, vol.7
, pp. 37-42
-
-
Cowburn, P.J.1
Cleland, J.G.2
McDonagh, T.A.3
-
25
-
-
16644384951
-
Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism
-
Goddard J, Eckhart C, Johnston NR, et al. Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism. J Am Soc Nephrol 2004;15:2601-10.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 2601-2610
-
-
Goddard, J.1
Eckhart, C.2
Johnston, N.R.3
-
26
-
-
12844253061
-
Endothelial function: Cardiac events
-
Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation 2005;111:363-8.
-
(2005)
Circulation
, vol.111
, pp. 363-368
-
-
Lerman, A.1
Zeiher, A.M.2
-
27
-
-
0035941416
-
Coronary vasodilation and improvement in endothelial dysfunction with endothelin ET(A) receptor blockade
-
Halcox JP, Nour KR, Zalos G, et al. Coronary vasodilation and improvement in endothelial dysfunction with endothelin ET(A) receptor blockade. Circ Res 2001;89:969-76.
-
(2001)
Circ Res
, vol.89
, pp. 969-976
-
-
Halcox, J.P.1
Nour, K.R.2
Zalos, G.3
-
29
-
-
0036266042
-
International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature
-
Davenport AP. International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Pharmacol Rev 2002;54:219-26.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 219-226
-
-
Davenport, A.P.1
-
30
-
-
18244416362
-
Endothelin antagonists and hypertension: A question of dose?
-
Goddard J, Webb DJ. Endothelin antagonists and hypertension: a question of dose? Hypertension 2002;40:e1-2.
-
(2002)
Hypertension
, vol.40
-
-
Goddard, J.1
Webb, D.J.2
-
31
-
-
0034780026
-
Systemic ETA receptor antagonism with BQ-123 blocks ET-1 induced forearm vasoconstriction and decreases peripheral vascular resistance in healthy men
-
Spratt JC, Goddard J, Patel N, et al. Systemic ETA receptor antagonism with BQ-123 blocks ET-1 induced forearm vasoconstriction and decreases peripheral vascular resistance in healthy men. Br J Pharmacol 2001;134:648-54.
-
(2001)
Br J Pharmacol
, vol.134
, pp. 648-654
-
-
Spratt, J.C.1
Goddard, J.2
Patel, N.3
-
32
-
-
22044435149
-
Specific inhibition of the endothelin A receptor with ZD4054: Clinical and pre-clinical evidence
-
Morris CD, Rose A, Curwen J, et al. Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence. Br J Cancer 2005;92:2148-52.
-
(2005)
Br J Cancer
, vol.92
, pp. 2148-2152
-
-
Morris, C.D.1
Rose, A.2
Curwen, J.3
-
33
-
-
0033032181
-
Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist
-
Nishikibe M, Ohta H, Okada M, et al. Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist. J Pharmacol Exp Ther 1999;289: 1262-70.
-
(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 1262-1270
-
-
Nishikibe, M.1
Ohta, H.2
Okada, M.3
-
34
-
-
0028292620
-
Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist
-
Clozel M, Breu V, Gray GA, et al. Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J Pharmacol Exp Ther 1994;270:228-35.
-
(1994)
J Pharmacol Exp Ther
, vol.270
, pp. 228-235
-
-
Clozel, M.1
Breu, V.2
Gray, G.A.3
-
35
-
-
0032766706
-
Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use
-
Clozel M, Ramuz H, Clozel JP, et al. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther 1999;290:840-6.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 840-846
-
-
Clozel, M.1
Ramuz, H.2
Clozel, J.P.3
-
36
-
-
0030077787
-
Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist
-
Ohlstein EH, Nambi P, Logo A, et al. Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist. J Pharmacol Exp Ther 1996;276:609-15.
-
(1996)
J Pharmacol Exp Ther
, vol.276
, pp. 609-615
-
-
Ohlstein, E.H.1
Nambi, P.2
Logo, A.3
-
37
-
-
0029815675
-
Oral treatment with a selective ETA-receptor antagonist inhibits neointima formation induced by endothelial injury
-
Munter K, Hergenroder L, Unger L, et al. Oral treatment with a selective ETA-receptor antagonist inhibits neointima formation induced by endothelial injury. Pharm Pharmacol Lett 1996;6:90-2.
-
(1996)
Pharm Pharmacol Lett
, vol.6
, pp. 90-92
-
-
Munter, K.1
Hergenroder, L.2
Unger, L.3
-
38
-
-
0030077247
-
Pharmacological characterization or A-127722: An orally active and highly potent ETA-selective receptor antagonist
-
Opgenorth TJ, Adler AL, Calzadilla SV, et al. Pharmacological characterization or A-127722: an orally active and highly potent ETA-selective receptor antagonist. J Pharmacol Exp Ther 1996;276:473-81.
-
(1996)
J Pharmacol Exp Ther
, vol.276
, pp. 473-481
-
-
Opgenorth, T.J.1
Adler, A.L.2
Calzadilla, S.V.3
-
39
-
-
0026631171
-
Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications
-
Ishikawa K, Fukami T, Nagase T, et al. Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications. J Med Chem 1992;35:2139-42.
-
(1992)
J Med Chem
, vol.35
, pp. 2139-2142
-
-
Ishikawa, K.1
Fukami, T.2
Nagase, T.3
-
40
-
-
0030943903
-
Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist
-
Wu C, Chan MF, Stavros F, et al. Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist. J Med Chem 1997;40:1690-7.
-
(1997)
J Med Chem
, vol.40
, pp. 1690-1697
-
-
Wu, C.1
Chan, M.F.2
Stavros, F.3
-
41
-
-
4444277521
-
Clinical trial registration: A statement from the International Committee of Medical Journal Editors
-
De Angelis C, Drazen JM, Frizelle FA, et al. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Lancet 2004;364:911-12.
-
(2004)
Lancet
, vol.364
, pp. 911-912
-
-
De Angelis, C.1
Drazen, J.M.2
Frizelle, F.A.3
-
42
-
-
29544450049
-
Trial registration report card
-
Drazen JM, Wood AJ. Trial registration report card. N Engl J Med 2005;353:2809-11.
-
(2005)
N Engl J Med
, vol.353
, pp. 2809-2811
-
-
Drazen, J.M.1
Wood, A.J.2
-
43
-
-
17844372209
-
Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1)
-
Krleza-Jeric K, Chan AW, Dickersin K, et al. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). BMJ 2005;330:956-8.
-
(2005)
BMJ
, vol.330
, pp. 956-958
-
-
Krleza-Jeric, K.1
Chan, A.W.2
Dickersin, K.3
-
44
-
-
0034720820
-
Acute endothelin A receptor blockade causes selective pulmonary vasodilation in patients with chronic heart failure
-
Givertz MM, Colucci WS, LeJemtel TH, et al. Acute endothelin A receptor blockade causes selective pulmonary vasodilation in patients with chronic heart failure. Circulation 2000;101:2922-7.
-
(2000)
Circulation
, vol.101
, pp. 2922-2927
-
-
Givertz, M.M.1
Colucci, W.S.2
LeJemtel, T.H.3
|