-
1
-
-
1542513764
-
-
Hainsworth JD: Prolonging remission with rituximab maintenance therapy. Semin Oncol 2004, 31(1 Suppl 2):17-21. This review describes clinical findings of prolongation of survival or remission in patients with non-Hodgkin's lymphoma (NHL) with rituximab maintenance therapy. The response rate of patients with untreated, indolent NHL who were first treated with rituximab followed by maintenance treatment improved from 47% after initial treatment to 73% after maintenance treatment.
-
Hainsworth JD: Prolonging remission with rituximab maintenance therapy. Semin Oncol 2004, 31(1 Suppl 2):17-21. This review describes clinical findings of prolongation of survival or remission in patients with non-Hodgkin's lymphoma (NHL) with rituximab maintenance therapy. The response rate of patients with untreated, indolent NHL who were first treated with rituximab followed by maintenance treatment improved from 47% after initial treatment to 73% after maintenance treatment.
-
-
-
-
2
-
-
26044436879
-
First-line treatment of follicular lymphoma in the era of monoclonal antibodies
-
This review describes the outcome of patients with NHL who were treated with rituximab alone or in combination with chemotherapy. The combination treatment resulted in a higher complete response rate and longer time to progression than treatment with rituximab alone
-
Coiffier B: First-line treatment of follicular lymphoma in the era of monoclonal antibodies. Clin Adv Hematol Oncol 2005, 3:484-491. This review describes the outcome of patients with NHL who were treated with rituximab alone or in combination with chemotherapy. The combination treatment resulted in a higher complete response rate and longer time to progression than treatment with rituximab alone.
-
(2005)
Clin Adv Hematol Oncol
, vol.3
, pp. 484-491
-
-
Coiffier, B.1
-
3
-
-
16444363534
-
-
Jazirehi AR, Bonavida B: Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: implications in chemosensitization and therapeutic intervention [review]. Oncogens 2005, 24:2121-2143. This recent review is the first to describe the effect of rituximab treatment on cell signaling and the modification of survival signaling pathways by rituximab in the laboratory. It also describes gene products involved in resistance to chemotherapy and characterizes the mechanism of rituximab resistance.
-
Jazirehi AR, Bonavida B: Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: implications in chemosensitization and therapeutic intervention [review]. Oncogens 2005, 24:2121-2143. This recent review is the first to describe the effect of rituximab treatment on cell signaling and the modification of survival signaling pathways by rituximab in the laboratory. It also describes gene products involved in resistance to chemotherapy and characterizes the mechanism of rituximab resistance.
-
-
-
-
4
-
-
0028057250
-
Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20
-
Reff ME, Carner K, Chambers KS, et al.: Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood 1994, 83:435-445.
-
(1994)
Blood
, vol.83
, pp. 435-445
-
-
Reff, M.E.1
Carner, K.2
Chambers, K.S.3
-
5
-
-
0037306990
-
An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition, and killing of CD20+ cells by rituximab
-
Kennedy AD, Solga MD, Schuman TA, et al.: An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition, and killing of CD20+ cells by rituximab. Blood 2003, 101:1071-1079.
-
(2003)
Blood
, vol.101
, pp. 1071-1079
-
-
Kennedy, A.D.1
Solga, M.D.2
Schuman, T.A.3
-
6
-
-
0034104375
-
Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells
-
Shan D, Ledbetter JA, Press OW: Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells. Cancer Immunol Immunother 2000, 48:673-683.
-
(2000)
Cancer Immunol Immunother
, vol.48
, pp. 673-683
-
-
Shan, D.1
Ledbetter, J.A.2
Press, O.W.3
-
7
-
-
0030800131
-
Chimeric anti-CD20 (IDEC-C2B8) monoclonal antibody sensitizes a B cell lymphoma cell line to cell killing by cytotoxic drugs
-
Demidem A, Lam T, Alas S, et al.: Chimeric anti-CD20 (IDEC-C2B8) monoclonal antibody sensitizes a B cell lymphoma cell line to cell killing by cytotoxic drugs. Cancer Biother Radiopharm 1997, 12:177-186.
-
(1997)
Cancer Biother Radiopharm
, vol.12
, pp. 177-186
-
-
Demidem, A.1
Lam, T.2
Alas, S.3
-
8
-
-
0034894958
-
Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis
-
Alas S, Emmanouilides C, Bonavida B: Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis. Clin Cancer Res 2001, 7:709-723.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 709-723
-
-
Alas, S.1
Emmanouilides, C.2
Bonavida, B.3
-
9
-
-
11144224182
-
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription
-
Li Z, David G, Hung KW, et al.: Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J Biol Chem 2004, 279:54438-54444.
-
(2004)
J Biol Chem
, vol.279
, pp. 54438-54444
-
-
Li, Z.1
David, G.2
Hung, K.W.3
-
10
-
-
16544389341
-
The biology of CD20 and its potential as a target for mAb therapy [review]
-
This extensive review describes the effect of rituximab treatment on the cell membrane lipid rafts and inhibition of cell signaling. In addition, it provides possible underlying mechanisms of responsiveness and unresponsiveness to rituximab
-
Cragg MS, Walshe CA, Ivanov AO, Glennie MJ: The biology of CD20 and its potential as a target for mAb therapy [review]. Curr Dir Autoimmun 2005, 8:140-174. This extensive review describes the effect of rituximab treatment on the cell membrane lipid rafts and inhibition of cell signaling. In addition, it provides possible underlying mechanisms of responsiveness and unresponsiveness to rituximab.
-
(2005)
Curr Dir Autoimmun
, vol.8
, pp. 140-174
-
-
Cragg, M.S.1
Walshe, C.A.2
Ivanov, A.O.3
Glennie, M.J.4
-
11
-
-
0029115799
-
Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20
-
Deans JP, Kalt L, Ledbetter JA, et al.: Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20. J Biol Chem 1995, 270:22632-22638.
-
(1995)
J Biol Chem
, vol.270
, pp. 22632-22638
-
-
Deans, J.P.1
Kalt, L.2
Ledbetter, J.A.3
-
12
-
-
0031962079
-
Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment
-
Deans JP, Robbins SM, Polyak MJ, Savage JA: Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment. J Biol Chem 1998, 273:344-348.
-
(1998)
J Biol Chem
, vol.273
, pp. 344-348
-
-
Deans, J.P.1
Robbins, S.M.2
Polyak, M.J.3
Savage, J.A.4
-
13
-
-
0037439821
-
Anti-CD20 therapeutic antibody rituximab modifies the functional organization of rafts/microdomains of B lymphoma cells
-
Semac I, Palomba C, Kulangara K, et al.: Anti-CD20 therapeutic antibody rituximab modifies the functional organization of rafts/microdomains of B lymphoma cells. Cancer Res 2003, 63:534-540.
-
(2003)
Cancer Res
, vol.63
, pp. 534-540
-
-
Semac, I.1
Palomba, C.2
Kulangara, K.3
-
14
-
-
4944264724
-
-
Jazirehi AR, Vega MI, Chatterjee D, et al.: Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab. Cancer Res 2004, 64:117-126. This study reveals for the first time that rituximab treatment of NHL cell lines inhibits the MEK1/2-ERK1/2 signaling pathways, resulting in inhibition of AP-1 and Bcl-x transcription. These events led to chemosensitization. This study also demonstrates that rituximab treatment resulted in the induction of RKIP expression and participated in the inhibition of the MEK1/2 signaling pathway.
-
Jazirehi AR, Vega MI, Chatterjee D, et al.: Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab. Cancer Res 2004, 64:117-126. This study reveals for the first time that rituximab treatment of NHL cell lines inhibits the MEK1/2-ERK1/2 signaling pathways, resulting in inhibition of AP-1 and Bcl-x transcription. These events led to chemosensitization. This study also demonstrates that rituximab treatment resulted in the induction of RKIP expression and participated in the inhibition of the MEK1/2 signaling pathway.
-
-
-
-
15
-
-
3843139379
-
-
Bezombes C, Grazide S, Garret C, et al.: Rituximab anti-proliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains. Blood 2004, 104:1166-1173. This study describes the mechanisms by which rituximab inhibits cell growth and demonstrates a rituximab-induced rapid and transient increase in acid sphingomyelinase activity. This was accompanied by ceramide generation in raft microdomains and resulted in the induction of cyclic-dependent kinase inhibitors involved in cell proliferation.
-
Bezombes C, Grazide S, Garret C, et al.: Rituximab anti-proliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains. Blood 2004, 104:1166-1173. This study describes the mechanisms by which rituximab inhibits cell growth and demonstrates a rituximab-induced rapid and transient increase in acid sphingomyelinase activity. This was accompanied by ceramide generation in raft microdomains and resulted in the induction of cyclic-dependent kinase inhibitors involved in cell proliferation.
-
-
-
-
16
-
-
0036408912
-
CD20-mediated apoptosis: Signalling through lipid rafts
-
Deans JP, Li H, Polyak MJ: CD20-mediated apoptosis: signalling through lipid rafts. Immunology 2002, 107:176-182.
-
(2002)
Immunology
, vol.107
, pp. 176-182
-
-
Deans, J.P.1
Li, H.2
Polyak, M.J.3
-
17
-
-
0028880675
-
Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines
-
Borsellino N, Belldegrun A, Bonavida B: Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines. Cancer Res 1995, 55:4633-4639.
-
(1995)
Cancer Res
, vol.55
, pp. 4633-4639
-
-
Borsellino, N.1
Belldegrun, A.2
Bonavida, B.3
-
18
-
-
0028174924
-
Overcoming TNF-alpha and drug resistance of human renal cell carcinoma cells by treatment with pentoxifylline in combination with TNF-alpha or drugs: The role of TNF-alpha mRNA downregulation in tumor cell sensitization
-
Mizutani Y, Bonavida B, Nio Y, Yoshida O: Overcoming TNF-alpha and drug resistance of human renal cell carcinoma cells by treatment with pentoxifylline in combination with TNF-alpha or drugs: the role of TNF-alpha mRNA downregulation in tumor cell sensitization. J Urol 1994, 151:1697-1702.
-
(1994)
J Urol
, vol.151
, pp. 1697-1702
-
-
Mizutani, Y.1
Bonavida, B.2
Nio, Y.3
Yoshida, O.4
-
19
-
-
0034725025
-
Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol
-
Su L, David M: Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol. J Biol Chem 2000, 275:12661-12666.
-
(2000)
J Biol Chem
, vol.275
, pp. 12661-12666
-
-
Su, L.1
David, M.2
-
20
-
-
0027434991
-
Serum interleukin-10 in non-Hodgkin's lymphoma: A prognostic factor
-
Blay JY, Burdin N, Rousset F, et al.: Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor. Blood 1993, 82:2169-2174.
-
(1993)
Blood
, vol.82
, pp. 2169-2174
-
-
Blay, J.Y.1
Burdin, N.2
Rousset, F.3
-
21
-
-
0036307780
-
Rituximab modifies the cisplatin- mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma
-
Alas S, Ng CP, Bonavida B: Rituximab modifies the cisplatin- mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma. Clin Cancer Res 2002, 8:836-845.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 836-845
-
-
Alas, S.1
Ng, C.P.2
Bonavida, B.3
-
22
-
-
2442684327
-
-
Vega MI, Huerta-Yepaz S, Garban H, et al, Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: pivotal role of p38 MAPK in drug resistance. Oncogene 2004, 23:3530-3540. This study shows that rituximab-induced inhibition of the IL-10-IL-10R loop in 2F7 DL-DCL resulted from inhibition of p38 MAPK and Sp1, which inhibited IL-10 transcription. Thus, rituximab-mediated inhibition of the p38 MAPK/Sp1/IL10-IL-10R/pSTAT3/Bcl-2 pathway was responsible for chemosensitization
-
Vega MI, Huerta-Yepaz S, Garban H, et al.: Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: pivotal role of p38 MAPK in drug resistance. Oncogene 2004, 23:3530-3540. This study shows that rituximab-induced inhibition of the IL-10-IL-10R loop in 2F7 DL-DCL resulted from inhibition of p38 MAPK and Sp1, which inhibited IL-10 transcription. Thus, rituximab-mediated inhibition of the p38 MAPK/Sp1/IL10-IL-10R/pSTAT3/Bcl-2 pathway was responsible for chemosensitization.
-
-
-
-
23
-
-
2442681173
-
Rituximab (anti-CD20) selectively modifies Bcl-xL and apoptosis protease activating factor-1 (Apaf-1) expression and sensitizes human non-Hodgkin's lymphoma B cell lines to paclitaxel-induced apoptosis
-
Jazirehi AR, Gan XH, De Vos S, et al: Rituximab (anti-CD20) selectively modifies Bcl-xL and apoptosis protease activating factor-1 (Apaf-1) expression and sensitizes human non-Hodgkin's lymphoma B cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther 2003, 2:1183-1193.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 1183-1193
-
-
Jazirehi, A.R.1
Gan, X.H.2
De Vos, S.3
-
24
-
-
0029927494
-
Predominant expression of the long isoform of Bcl-x (Bcl-xL) in human lymphomas
-
Xerri L, Parc P, Brousset P, et al.: Predominant expression of the long isoform of Bcl-x (Bcl-xL) in human lymphomas. Br J Haematol 1996, 92:900-906.
-
(1996)
Br J Haematol
, vol.92
, pp. 900-906
-
-
Xerri, L.1
Parc, P.2
Brousset, P.3
-
25
-
-
0033539167
-
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
-
Yeung K, Seitz T, Li S, et al.: Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 1999, 401:173-177.
-
(1999)
Nature
, vol.401
, pp. 173-177
-
-
Yeung, K.1
Seitz, T.2
Li, S.3
-
26
-
-
0034003003
-
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein
-
Yeung K, Janosch P, McFerran B, et al.: Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol 2000, 20:3079-3085.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3079-3085
-
-
Yeung, K.1
Janosch, P.2
McFerran, B.3
-
27
-
-
0036234459
-
Missing pieces in the NF-κB puzzle [review]
-
Ghosh S, Karin M: Missing pieces in the NF-κB puzzle [review]. Cell 2002, 109:81-96.
-
(2002)
Cell
, vol.109
, pp. 81-96
-
-
Ghosh, S.1
Karin, M.2
-
28
-
-
0037184348
-
NF-κB signaling. Many roads lead to Madrid
-
Dixit V, Mak TW: NF-κB signaling. Many roads lead to Madrid. Cell 2002, 111:615-619.
-
(2002)
Cell
, vol.111
, pp. 615-619
-
-
Dixit, V.1
Mak, T.W.2
-
29
-
-
0034791116
-
Raf kinase inhibitor protein interacts with NF-κB-inducing kinase and TAK1 and inhibits NF-κB activation
-
Yeung KC, Rose DW, Dhillon AS, et al.: Raf kinase inhibitor protein interacts with NF-κB-inducing kinase and TAK1 and inhibits NF-κB activation. Mol Cell Biol 2001, 21:7207-7217.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7207-7217
-
-
Yeung, K.C.1
Rose, D.W.2
Dhillon, A.S.3
-
30
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer [review]
-
Vivanco I, Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer [review]. Nat Rev Cancer 2002, 2:489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
31
-
-
84952636614
-
Rituximab sensitizes resistant B-NHL cell lines to proteasome inhibitor NPI-0052-induced apoptosis [abstract]
-
Abstract 5429
-
Suzuki E, Palladino M, Bonavida B: Rituximab sensitizes resistant B-NHL cell lines to proteasome inhibitor NPI-0052-induced apoptosis [abstract]. Proc Amer Assoc Cancer Res 2006, 47:Abstract 5429.
-
(2006)
Proc Amer Assoc Cancer Res
, vol.47
-
-
Suzuki, E.1
Palladino, M.2
Bonavida, B.3
-
32
-
-
24644514459
-
Inhibition of the transcription factor yin yang 1 activity by S-nitrosation
-
Hongo F, Garban H, Huerta-Yepez S, et al.: Inhibition of the transcription factor yin yang 1 activity by S-nitrosation. Biochem Biophys Res Commun 2005, 336:692-701.
-
(2005)
Biochem Biophys Res Commun
, vol.336
, pp. 692-701
-
-
Hongo, F.1
Garban, H.2
Huerta-Yepez, S.3
-
33
-
-
3042737429
-
Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-κB and inhibition of Bcl-xl expression
-
Huerta-Yepez S, Vega M, Jazirehi A, et al.: Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-κB and inhibition of Bcl-xl expression. Oncogene 2004, 23:4993-5003.
-
(2004)
Oncogene
, vol.23
, pp. 4993-5003
-
-
Huerta-Yepez, S.1
Vega, M.2
Jazirehi, A.3
-
34
-
-
0035399797
-
Nitric oxide inhibits the transcription repressor yin-yang 1 binding activity at the silencer region of the Fas promoter: A pivotal role for nitric oxide in the up-regulation of Fas gene expression in human tumor cells
-
Garban HJ, Bonavida B: Nitric oxide inhibits the transcription repressor yin-yang 1 binding activity at the silencer region of the Fas promoter: a pivotal role for nitric oxide in the up-regulation of Fas gene expression in human tumor cells. J Immunol 2001, 167:75-81.
-
(2001)
J Immunol
, vol.167
, pp. 75-81
-
-
Garban, H.J.1
Bonavida, B.2
-
36
-
-
23444459884
-
-
Vega MI, Jazirehi AR, Huerta-Yepez S, Bonavida B: Rituximab-induced inhibition of YY1 and Bcl-xL expression in Ramos non-Hodgkin's lymphoma cell line via inhibition of NF-kappa B activity: role of YY1 and Bcl-xL in Fas resistance and chemoresistance, respectively. J Immunol 2005, 175:2174-2183. This study describes for the first time the effect of rituximab-induced upregulation of the death receptor Fas via inhibition of the transcription repressor YY1, resulting in the sensitization of NHL cells to Fas ligand-induced apoptosis. This finding suggests a novel mechanism of rituximab-mediated effect in vivo.
-
Vega MI, Jazirehi AR, Huerta-Yepez S, Bonavida B: Rituximab-induced inhibition of YY1 and Bcl-xL expression in Ramos non-Hodgkin's lymphoma cell line via inhibition of NF-kappa B activity: role of YY1 and Bcl-xL in Fas resistance and chemoresistance, respectively. J Immunol 2005, 175:2174-2183. This study describes for the first time the effect of rituximab-induced upregulation of the death receptor Fas via inhibition of the transcription repressor YY1, resulting in the sensitization of NHL cells to Fas ligand-induced apoptosis. This finding suggests a novel mechanism of rituximab-mediated effect in vivo.
-
-
-
-
37
-
-
1342282157
-
Rituximab infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia
-
Kennedy AD, Beum PV, Solga MD, et al.: Rituximab infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia. J Immunol 2004, 172:3280-3288.
-
(2004)
J Immunol
, vol.172
, pp. 3280-3288
-
-
Kennedy, A.D.1
Beum, P.V.2
Solga, M.D.3
-
38
-
-
0038556846
-
Loss of CD20 expression in relapsed lymphomas after rituximab therapy
-
Haidar JH, Shamseddine A, Salem Z, et al.: Loss of CD20 expression in relapsed lymphomas after rituximab therapy. Eur J Hematol 2003, 70:330-332.
-
(2003)
Eur J Hematol
, vol.70
, pp. 330-332
-
-
Haidar, J.H.1
Shamseddine, A.2
Salem, Z.3
-
39
-
-
0038446696
-
Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance
-
Manshouri T, Do KA, Wang X, et al.: Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance. Blood 2003, 101:2507-2513.
-
(2003)
Blood
, vol.101
, pp. 2507-2513
-
-
Manshouri, T.1
Do, K.A.2
Wang, X.3
-
40
-
-
84868375458
-
-
Jazirehi AR, Bonavida B: Cellular and molecular characterization of rituximab-resistant CD20+ NHL Ramos (Ramos RR1) and Daudi (Daudi RR1) clones: development of cross-resistance to cytotoxic stimuli [abstract]. Blood (ASH Annual Meeting Abstracts) 2004, 104:Abstract 3410. This study describes the generation of rituximab-resistant clones as a model to mimic rituximab unresponsiveness in patients. It demonstrates that the resistant clones fail to be triggered by rituximab and cannot be chemosensitized by rituximab. However, the clones can be sensitized by pharmacologic inhibitors of the ERK1/2 and NF-κB pathways.
-
Jazirehi AR, Bonavida B: Cellular and molecular characterization of rituximab-resistant CD20+ NHL Ramos (Ramos RR1) and Daudi (Daudi RR1) clones: development of cross-resistance to cytotoxic stimuli [abstract]. Blood (ASH Annual Meeting Abstracts) 2004, 104:Abstract 3410. This study describes the generation of rituximab-resistant clones as a model to mimic rituximab unresponsiveness in patients. It demonstrates that the resistant clones fail to be triggered by rituximab and cannot be chemosensitized by rituximab. However, the clones can be sensitized by pharmacologic inhibitors of the ERK1/2 and NF-κB pathways.
-
-
-
-
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-
-
84868342102
-
-
Jazirehi AR, Bonavida B: Sensitization of rituximab-sensitive and rituximab-resistant B-NHL cell lines/clones to TRAIL-induced apoptosis by bortezomib and NF-κB inhibitors [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:Abstract 1514. This study demonstrates that rituximab treatment of NHL cell lines upregulates the expression of the death receptor DR5 and sensitizes the cells to TRAIL-induced apoptosis. In addition, treatment with bortezomib and NF-κB inhibitors mimics rituximab and sensitizes the cells to TRAIL-induced apoptosis.
-
Jazirehi AR, Bonavida B: Sensitization of rituximab-sensitive and rituximab-resistant B-NHL cell lines/clones to TRAIL-induced apoptosis by bortezomib and NF-κB inhibitors [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:Abstract 1514. This study demonstrates that rituximab treatment of NHL cell lines upregulates the expression of the death receptor DR5 and sensitizes the cells to TRAIL-induced apoptosis. In addition, treatment with bortezomib and NF-κB inhibitors mimics rituximab and sensitizes the cells to TRAIL-induced apoptosis.
-
-
-
-
42
-
-
33846249531
-
New targets identified for therapeutic intervention in the reversal of rituximab and drug resistant AIDS-B-NHL [abstract]
-
Abstract 5424
-
Vega M, Jazirehi AR, Bonavida B: New targets identified for therapeutic intervention in the reversal of rituximab and drug resistant AIDS-B-NHL [abstract]. Proc Amer Assoc Cancer Res 2006, 47:Abstract 5424.
-
(2006)
Proc Amer Assoc Cancer Res
, vol.47
-
-
Vega, M.1
Jazirehi, A.R.2
Bonavida, B.3
-
43
-
-
33847050751
-
Characteristics of rituximab-resistant B-NHL clones in lipid raft microdomains and cell signaling [abstract]
-
Abstract 4657
-
Jazirehi AR, Bezombes C, Laurant G, et al.: Characteristics of rituximab-resistant B-NHL clones in lipid raft microdomains and cell signaling [abstract]. Proc Amer Assoc Cancer Res 2006, 47:Abstract 4657.
-
(2006)
Proc Amer Assoc Cancer Res
, vol.47
-
-
Jazirehi, A.R.1
Bezombes, C.2
Laurant, G.3
-
44
-
-
0037236924
-
Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis
-
Alas SA, Bonavida B: Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. Clin Cancer Res 2003, 9:316-326.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 316-326
-
-
Alas, S.A.1
Bonavida, B.2
-
45
-
-
0036928350
-
Rituximab-mediated sensitization of B-non-Hodgkin's lymphoma (NHL) to cytotoxicity induced by paclitaxel, gemcitabine, and vinorelbine
-
Emmanouilides C, Jazirehi A, Bonavida B: Rituximab-mediated sensitization of B-non-Hodgkin's lymphoma (NHL) to cytotoxicity induced by paclitaxel, gemcitabine, and vinorelbine. Cancer Biother Radiopharm 2002, 17:621-630.
-
(2002)
Cancer Biother Radiopharm
, vol.17
, pp. 621-630
-
-
Emmanouilides, C.1
Jazirehi, A.2
Bonavida, B.3
-
46
-
-
11244254238
-
-
Jazirehi AR, Huerta-Yepez S, Cheng G, Bonavida B: Rituximab (chimeric anti-CD20 mAb) inhibits the constitutive NIK/IKK/IκB/NF-κB signaling pathway in non-Hodgkin's lymphoma (NHL) B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis. Cancer Res 2005, 65:264-276. This report describes for the first time rituximab-induces inhibition of the NF-κB pathway leading to inhibition of Bcl-x transcription and expression and leading to chemosensitization.
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Jazirehi AR, Huerta-Yepez S, Cheng G, Bonavida B: Rituximab (chimeric anti-CD20 mAb) inhibits the constitutive NIK/IKK/IκB/NF-κB signaling pathway in non-Hodgkin's lymphoma (NHL) B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis. Cancer Res 2005, 65:264-276. This report describes for the first time rituximab-induces inhibition of the NF-κB pathway leading to inhibition of Bcl-x transcription and expression and leading to chemosensitization.
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