Characterization of polVR391: A Y-family polymerase encoded by rumA′B from the IncJ conjugative transposon, R391

Molecular Microbiology

Volumn 63, Issue 3, 2007, Pages 797-810

  Mead, Samantha ^a   Vaisman, Alexandra ^a   Valjavec Gratian, Majda ^a,b   Karata, Kiyonobu ^a   Vandewiele, Dominique ^a   Woodgate, Roger ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b KEVRIC Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; PYRIMIDINE; DNA DIRECTED DNA POLYMERASE; ESCHERICHIA COLI PROTEIN; POLV(R391) PROTEIN, E COLI; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ESCHERICHIA COLI; GENE MUTATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSPOSON; DNA REPAIR; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ESCHERICHIA COLI;

DNA TRANSPOSABLE ELEMENTS; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MUTAGENESIS; SOS RESPONSE (GENETICS);

EID: 33846202838     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2006.05561.x     Document Type: Article

References (40)

1. Altschul, S.F., Gish, W., Miller, W., Myers, E.W., and Lipman, D.J. (1990) Basic local alignment search tool. J Mol Biol 215: 403-410.
2. Bagg, A., Kenyon, C.J., and Walker, G.C. (1981) Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coli. Proc Natl Acad Sci USA 78: 5749-5753.
3. Benson, D.A., Karsch-Mizrachi, I., Lipman, D.J., Ostell, J., and Wheeler, D.L. (2006) GenBank. Nucleic Acids Res 34: D16-D20.
4. Blanco, M., Herrera, G., and Aleixandre, V. (1986) Different efficiency of UmuDC and MucAB proteins in UV light induced mutagenesis of Escherichia coli. Mol Gen Genet 205: 234-239.
5. Bruck, I., Woodgate, R., McEntee, K., and Goodman, M.F. (1996) Purification of a soluble UmuD′C complex from Escherichia coli: cooperative binding of UmuD′C to single-stranded DNA. J Biol Chem 271: 10767-10774.
6. Burckhardt, S.E., Woodgate, R., Scheuermann, R.H., and Echols, H. (1988) UmuD mutagenesis protein of Escherichia coli: overproduction, purification and cleavage by RecA. Proc Natl Acad Sci USA 85: 1811-1815.
7. Churchward, G., Belin, D., and Nagamine, Y. (1984) A pSC101-derived plasmid which shows no sequence homology to other commonly used cloning vectors. Gene 31: 165-171.
8. Davis, B.D., and Mingioli, E.S. (1950) Mutants of Escherichia coli requiring methionine or vitamin B12. J Bacteriol 60: 17-28.
9. Dutreix, M., Moreau, P.L., Bailone, A., Galibert, F., Battista, J.R., Walker, G.C., and Devoret, R. (1989) New recA mutations that dissociate the various RecA protein activities in Escherichia coli provide evidence for an additional role for RecA protein in UV mutagenesis. J Bacteriol 171: 2415-2423.
10. Fijalkowska, I.J., Dunn, R.L., and Schaaper, R.M. (1997) Genetic requirements and mutational specificity of the Escherichia coli SOS mutator activity. J Bacteriol 179: 7435-7445.
11. Frank, E.G., Hauser, J., Levine, A.S., and Woodgate, R. (1993) Targeting of the UmuD, UmuD′ and MucA′ mutagenesis proteins to DNA by RecA protein. Proc Natl Acad Sci USA 90: 8169-8173.
12. Friedberg, E.C., Walker, G.C., and Siede, W. (1995) DNA Repair and Mutagenesis. Washington, DC: American Society for Microbiology.
13. Fujii, S., Gasser, V., and Fuchs, R.P. (2004) The biochemical requirements of DNA polymerase V-mediated translesion synthesis revisited. J Mol Biol 341: 405-417.
14. Garibyan, L., Huang, T., Kim, M., Wolff, E., Nguyen, A., Nguyen, T., et al. (2003) Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosome. DNA Repair 2: 593-608.
15. Goldsmith, M., Sarov-Blat, L., and Livneh, Z. (2000) Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA′, RecA, and SSB. Proc Natl Acad Sci USA 97: 11227-11231.
16. 2C). Cold Spring Harb Symp Quant Biol 65: 31-40.
17. Ho, C., Kulaeva, O.I., Levine, A.S., and Woodgate, R. (1993) A rapid method for cloning mutagenic DNA repair genes: isolation of umu- complementing genes from multidrug resistance plasmids R391, R446b, and R471a. J Bacteriol 175: 5411-5419.
18. Kulaeva, O.I., Wootton, J.C., Levine, A.S., and Woodgate, R. (1995) Characterization of the umu-complementing operon from R391. J Bacteriol 177: 2737-2743.
19. Kulaeva, O.I., Koonin, E.V., Wootton, J.C., Levine, A.S., and Woodgate, R. (1998) Unusual insertion element polymorphisms in the promoter and terminator regions of the mucAB-like genes of R471a and R446b. Mutat Res 397: 247-262.
20. Nohmi, T., Battista, J.R., Dodson, L.A., and Walker, G.C. (1988) RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation. Proc Natl Acad Sci USA 85: 1816-1820.
21. Ohmori, H., Friedberg, E.C., Fuchs, R.P.P., Goodman, M.F., Hanaoka, F., Hinkle, D., et al. (2001) The Y-family of DNA polymerases. Mol Cell 8: 7-8.
22. Pages, V., Janel-Bintz, R., and Fuchs, R.P. (2005) Pol III proofreading activity prevents lesion bypass as evidenced by its molecular signature within E. coli cells. J Mol Biol 352: 501-509.
23. Perry, K.L., Elledge, S.J., Mitchell, B., Marsh, L., and Walker, G.C. (1985) umuDC and mucAB operons whose products are required for UV light and chemical-induced mutagenesis: UmuD, MucA, and LexA products share homology. Proc Natl Acad Sci USA 82: 4331-4335.
24. Rangarajan, S., Woodgate, R., and Goodman, M.F. (2002) Replication restart in UV-irradiated Escherichia coli involving pols II, III, V, PriA, RecA and RecFOR proteins. Mol Microbiol 43: 617-628.
25. Reuven, N.B., Tomer, G., and Livneh, Z. (1998) The mutagenesis proteins UmuD′ and UmuC prevent lethal frameshifts while increasing base substitution mutations. Mol Cell 2: 191-199.
26. Reuven, N.B., Arad, G., Maor-Shoshani, A., and Livneh, Z. (1999) The mutagenesis protein UmuC is a DNA polymerase activated by UmuD′, RecA, and SSB and Is specialized for translesion replication. J Biol Chem 274: 31763-31766.
27. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
28. Schlacher, K., Cox, M.M., Woodgate, R., and Goodman, M.F. (2006) RecA acts in trans to allow replication of damaged DNA by DNA polymerase V. Nature 442: 883-887.
29. Shinagawa, H., Iwasaki, H., Kato, T., and Nakata, A. (1988) RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis. Proc Natl Acad Sci USA 85: 1806-1810.
30. Sutton, M.D., Smith, B.T., Godoy, V.G., and Walker, G.C. (2001) The SOS response: recent insights into umuDC-dependent mutagenesis and DNA damage tolerance. Ann Rev Genet 34: 479-497.
31. Sweasy, J.B., Witkin, E.M., Sinha, N., and Roegner-Maniscalco, V. (1990) RecA protein of Escherichia coli has a third essential role in SOS mutator activity. J Bacteriol 172: 3030-3036.
32. Szekeres, E.S.J., Woodgate, R., and Lawrence, C.W. (1996) Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis. J Bacteriol 178: 2559-2563.
33. 2C mutagenic complex and RecA. Proc Natl Acad Sci USA 95: 9755-9760.
34. 2C is an error-prone DNA polymerase, Escherichia coli, DNA pol V. Proc Natl Acad Sci USA 96: 8919-8924.
35. Vandewiele, D., Fernandez de Henestrosa, A.R., Timms, A.R., Bridges, B.A., and Woodgate, R. (2002) Sequence analysis and phenotypes of five temperature sensitive mutator alleles of dnaE, encoding modified a-catalytic subunits of Escherichia coli DNA polymerase III holoenzyme. Mutat Res 499: 85-95.
36. Venderbure, C., Chastanet, A., Boudsocq, F., Sommer, S., and Bailone, A. (1999) Inhibition of homologous recombination by the plasmid MucA'B complex. J Bacteriol 181: 1249-1255.
37. Witkin, E.M., McCall, J.O., Volkert, M.R., and Wermundsen, I.E. (1982) Constitutive expression of SOS functions and modulation of mutagenesis resulting from resolution of genetic instability at or near the recA locus of Escherichia coli. Mol Gen. Genet 185: 43-50.
38. Wolff, E., Kim, M., Hu, K., Yang, H., and Miller, J.H. (2004) Polymerases leave fingerprints: analysis of the mutational spectrum in Escherichia coli rpoB to assess the role of polymerase IV in spontaneous mutation. J Bacteriol 186: 2900-2905.
39. Woodgate, R., Rajagopalan, M., Lu, C., and Echols, H. (1989) UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD′. Proc Natl Acad Sci USA 86: 7301-7305.
40. Young, L.C., Hays, J.B., Tron, V.A., and Andrew, S.E. (2003) DNA mismatch repair proteins: potential guardians against genomic instability and tumorigenesis induced by ultraviolet photoproducts. J Invest Dermatol 121: 435-440.