Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats

Toxicology

Volumn 230, Issue 2-3, 2007, Pages 145-150

  Zhao, Ying ^a,b   Zhai, Desheng ^b   Chen, Xijing ^a   Yang, Jinnan ^b   Song, Xiangfeng ^b   He, Hui ^a   Yu, Qiaoling ^a   Xing, Yan ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Alpha naphthylisothiocyanate; Bile excretion; Carbon tetrachloride; Glucuronidation; Hepatic injury; Ketoprofen

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; CARBON TETRACHLORIDE; GLUCURONOSYLTRANSFERASE; KETOPROFEN; KETOPROFEN DERIVATIVE; KETOPROFEN GLUCURONIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILE FLOW; CONTROLLED STUDY; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME ACTIVITY; IN VIVO STUDY; INCUBATION TIME; LIVER INJURY; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ALANINE TRANSAMINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BILE; BILIRUBIN; BLOOD UREA NITROGEN; CARBON TETRACHLORIDE POISONING; HISTOCYTOCHEMISTRY; ISOCYANATES; KETOPROFEN; LIVER; LIVER DISEASES; MALE; MICROSOMES, LIVER; NAPHTHALENES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 33846201721     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.11.008     Document Type: Article

References (12)

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