The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438

Molecular and Cellular Endocrinology

Volumn 264, Issue 1-2, 2007, Pages 164-170

  Owen, H C ^a,b   Miner, J N ^c   Ahmed, S F ^b   Farquharson, C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^c LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

Chondrocytes; Glucocorticoids; Growth plate; Proliferation

Indexed keywords

AL 438; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE GROWTH; CARTILAGE CELL; CELL PROLIFERATION; CELL STRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EMBRYO; FETUS; GROWTH PLATE; GROWTH RETARDATION; METATARSAL BONE; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOPYRANS; BONE DEVELOPMENT; CELL LINE; CHILD; CHILD, PRESCHOOL; CHONDROCYTES; DEXAMETHASONE; DRUG EVALUATION, PRECLINICAL; GLUCOCORTICOIDS; GROWTH DISORDERS; GROWTH PLATE; HUMANS; INTERLEUKIN-6; MICE; OSTEOBLASTS; PREDNISOLONE; QUINOLINES; RECEPTORS, GLUCOCORTICOID;

EID: 33846189394     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2006.11.006     Document Type: Article

References (37)

1. Ahmed S.F., Tucker P., Mushtaq T., Wallace A.M., Williams D.M., and Hughes I.A. Short-term effects on linear growth and bone turnover in children randomized to receive prednisolone or dexamethasone. Clin. Endocrinol. (Oxford) 57 (2002) 185-191
2. Atsumi T., Miwa Y., Kimata K., and Ikawa Y. A chondrogenic cell line derived from a differentiating culture AT805 teratocarcinoma cells. Cell Differ. Dev. 30 (1990) 109-116
3. Baron J., Huang Z., Oerter K.E., Bacher J.D., and Cutler Jr. G.B. Dexamethasone acts locally to inhibit longitudinal bone growth in rabbits. Am. J. Physiol. 263 (1992) E489-E492
4. Canalis E., and Avioli L. Effects of deflazacort on aspects of bone formation in cultures of intact calvariae and osteoblast-enriched cells. J. Bone Miner. Res. 7 (1992) 1085-1092
5. Chen W.S., Xu P.Z., Gottlob K., Chen M.L., Sokol K., Shiyanova T., Weng W., Suzuki R., Tobe K., Kadowaki T., and Hay N. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15 (2001) 2203-2208
6. Chrysis D., Zaman F., Chagin A.S., Takigawa M., and Savendahl L. Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3′-kinase signaling pathway. Endocrinology 146 (2005) 1391-1397
7. Coghlan M.J., Jacobson P.B., Lane B., Nakane M., Lin C.H., Elmore S., Kym P.R., Luly J.R., Carter G.W., Turner R., Tyree C.M., Hu J., Elgort M., Rosen J., and Miner J.N. A novel anti-inflammatory maintains glucocorticoid efficacy with reduced side effects. Mol. Endocrin. 17 (2003) 860-869
8. Coxam V., Miller M.A., Bowman M.B., and Miller S.C. Ontogenesis of IGF regulation of longitudinal bone growth in rat metatarsal rudiments cultured in serum-free medium. Arch. Physiol. Biochem. 104 (1996) 173-179
9. Diamond M.I., Miner J.N., Yoshinaga S.K., and Yamamoto K.R. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249 (1990) 1266-1272
10. Dupont J., and LeRoith D. Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction. Horm. Res. 55 (2001) 22-26
11. Elmore S.W., Coghlan M.J., Anderson D.D., Pratt J.K., Green B.E., Wang A.X., Stashko M.A., Lin C.W., Tyree C.M., Miner J.N., Jacobson P.B., Wilcox D.M., and Lane B.C. Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines. J. Med. Chem. 44 (2001) 4481-4491
12. Farquharson C. Bone growth. In: Scanes C.G. (Ed). Biology of Growth of Domestic Animals (2003), Iowa State Press, Iowa 170-185
13. Farquharson C., Lester D., Seawright E., Jeffries D., and Houston B. Microtubules are potential regulators of growth plate chondrocytes differentiation and hypertrophy. Bone 25 (1999) 40
14. Fujita T., Fukuyama R., Enomoto H., and Komori T. Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signalling and DNA binding of Runx2. J. Cell. Biochem. 93 (2004) 374-383
15. Gabrielsson B.G., Carmignac D.F., Flavell D.M., and Robinson I.C. Steroid regulation of growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids in the rat. Endocrinology 136 (1995) 209-218
16. Hench S., Kendall E.C., Slocumb C.H., and Polley H.F. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc. Staff Meetings Mayo Clin. 24 (1949) 181-197
17. Jonat C., Rahmsdorf H.J., Park K.K., Cato A.C., Gebel S., Ponta H., and Herrlich P. Antitumor promotion and antiinflammation: down modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62 (1990) 1189-1204
18. Jux C., Leiber K., Hugel U., Blum W., Ohlsson C., Klaus G., and Mehls O. Dexamethasone impairs growth hormone (GH)-stimulated growth by suppression of local insulin-like growth factor (IGF-I) production and expression of GH and IGF-I receptor in cultured rat chondrocytes. Endocrinology 139 (1998) 3296-3305
19. Klaus G., Jux C., Fernandez P., Rodriguez J., Himmele R., and Mehls O. Suppression of growth plate chondrocyte proliferation by corticosteroids. Pediatr. Nephrol. 14 7 (1998) 612-615
20. Kronenberg H.M. Developmental regulation of the growth plate. Nature 423 (2003) 332-336
21. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-440
22. Markham A., and Bryson H.M. Deflazacort. A review of its pharmacological properties and therapeutic efficacy. Drugs 50 (1995) 317-333
23. Miner J.N. Designer glucocorticoids. Biochem. Pharmacol. 64 (2002) 355-361
24. Mushtaq T., and Ahmed S.F. The impact of corticosteroids on growth and bone health. Arch. Dis. Child 87 2 (2002) 93-96
25. Mushtaq T., Farquharson C., Seawright E., and Ahmed S.F. Glucocorticoid effects on chondrogenesis, differentiation and apoptosis in the murine ATDC5 chondrocyte cell line. J. Endocrinol. 175 (2002) 705-713
26. Mushtaq T., Bijman P., Ahmed S.F., and Farquharson C. Insulin-like growth factor-I augments chondrocyte hypertrophy and reverses glucocorticoid-mediated growth retardation in fetal mice metatarsal cultures. Endocrinology 145 (2004) 2478-2486
27. Picherit C., Coxam V., Oudadesse H., Martini B., Gaumet N., Davicco M.J., and Barlet J.P. Dihydrotestosterone prevents glucocorticoid-negative effects on fetal rat metatarsal bone in vitro. Biol. Neonate 77 (2000) 181-190
28. Robson H., Anderson E., Eden O.B., Isaksson O., and Shalet S. Chemotherapeutic agents used in the treatment of childhood malignancies have direct effects on growth plate chondrocyte proliferation. J. Endocrinol. 152 (1998) 225-235
29. Rosen J., and Miner J.N. The search for safer glucocorticoid receptor ligands. Endocr. Rev. 26 (2005) 452-464
30. Sanchez C.P., and He Y.Z. Alterations in the growth plate cartilage of rats with renal failure receiving corticosteroid therapy. Bone 30 (2002) 692-698
31. Scheven B.A., and Hamilton N.J. Longitudinal bone growth in vitro: effects of insulin-like growth factor I and growth hormone. Acta Endocrinol. 124 (1991) 602-607
32. Shukunami C., Ishizeki K., Atsumi T., Ohta Y., Suzuki F., and Hiraki Y. Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro. J. Bone Miner. Res. 12 (1997) 1174-1188
33. Silvestrini G., Mocetti P., Ballanti P., Di Grezia R., and Bonucci E. Cytochemical demonstration of the glucocorticoid receptor in skeletal cells of the rat. Endocr. Res. 25 (1999) 117-128
34. Smink J.J., Koster J.G., Gresnigt M.G., Rooman R., Koedam J.A., and Van Buul-Offers S.C. IGF and IGF-binding protein expression in the growth plate of normal, dexamethasone-treated and human IGF-II transgenic mice. J. Endocrinol. 175 (2002) 143-155
35. Smink J.J., Gresnigt M.G., Hamers N., Koedam J.A., Berger R., and Buul-Offers S.C. Short-term glucocorticoid treatment of pre-pubertal mice decreases growth and IGF-I expression in the growth plate. J. Endocrinol. 177 (2003) 381-388
36. Song I.H., and Buttgereit F. Non-genomic glucocorticoid effects to provide the basis for new drug developments. Mol. Cell. Endocrinol. 246 (2005) 142-146
37. Warner J. Review of prescribed treatment for children with asthma in 1990. BMJ 311 (1995) 663-666