Alterations in the growth plate cartilage of rats with renal failure receiving corticosteroid therapy

Bone

Volumn 30, Issue 5, 2002, Pages 692-698

  Sanchez, C P ^a   He, Y Z ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Chondrocyte apoptosis; Chondrocyte proliferation; Chronic renal failure; Corticosteroids; Growth plate cartilage; Growth retardation

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; COLLAGEN TYPE 2; CORTICOSTEROID; CREATININE; CYCLINE; GELATINASE B; HISTONE H4; METHYLPREDNISOLONE; PARATHYROID HORMONE; PROTEIN BAX; PROTEIN BCL 2; SOMATOMEDIN C RECEPTOR; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE GROWTH; CARTILAGE CELL; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CREATININE BLOOD LEVEL; DRUG EFFECT; GROWTH PLATE; GROWTH RETARDATION; KIDNEY FAILURE; KIDNEY FUNCTION; LEG LENGTHENING; MALE; NEPHRECTOMY; NICK END LABELING; NONHUMAN; PARATHYROID HORMONE BLOOD LEVEL; PHENOTYPE; PROTEIN EXPRESSION; RAT; TIBIA; UREA NITROGEN BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; BLOOD UREA NITROGEN; CELL DIVISION; CHONDROCYTES; COLLAGEN TYPE II; CREATININE; ENDOTHELIAL GROWTH FACTORS; GENE EXPRESSION; GLUCOCORTICOIDS; GROWTH PLATE; HISTONES; HYPERTROPHY; IN SITU NICK-END LABELING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY FAILURE, CHRONIC; LYMPHOKINES; MALE; METHYLPREDNISOLONE; NEPHRECTOMY; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECEPTOR, IGF TYPE 1; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036246322     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(02)00696-8     Document Type: Article

References (23)

1. A meta-analysis of the effect of oral and inhaled corticosteroids on growth
2. Collagen metabolism is markedly altered in the hypertrophic cartilage of growth plates from rats with growth impairment secondary to chronic renal failure
3. Glucocorticoid effects of statural growth
4. Mechanisms of glucocorticoid action in bone: Implications to glucocorticoid-induced osteoporosis
5. Acute effects of deflazacort and prednisone on rates of mineralization and bone formation
6. Altered trabecular architecture induced by corticosteroids: A bone histomorphometric study
7. Collagen metabolism and growth in prepubertal children with asthma treated with inhaled steroids
8. Selective reduction of bone blood flow by short-term treatment with high dose methylprednisolone
9. Inhaled corticosteroids reduce bone mineral density in early postmenopausal but not premenopausal asthmatic women
10. Dexamethasone impairs growth hormone (GH)-stimulated growth by suppression of local insulin-like growth factor (IGF)-1 production and expression of GH- and IGF-1 receptor in cultured rat chondrocytes
11. Suppression of growth plate chondrocyte proliferation by corticosteroids
12. Long-term reduction in bone mass after severe burn injury in children
13. Growth hormone prevents steroid-induced growth depression in health and uremia
14. Modulation of the effects of glucocorticoids on collagen synthesis in fetal rat calvariae by insulin-like growth factor binding protein-2
15. Bcl-2 and Bax expression in cartilage and bone cells after high-dose corticosterone treatment in rats
16. Detection of gelatinase B expression reveals osteoclastic bone resorption as a feature of early calvarial bone development
17. Users of low-dose glucocorticoids have increased bone loss rates: A longitudinal study
18. Skeletal response to recombinant human growth hormone (rhGH) in patients on long-term corticosteroids
19. Impaired growth, delayed ossification, and reduced osteoclastic activity in the growth plate of calcium-supplemented rats with renal failure
20. Growth of long bones in renal failure: Roles of hyperparathyroidism, growth hormone and calcitriol
21. Effect on bone growth of daily versus alternate-day corticosteroid administration: An experimental study
22. Expression of Bcl-2 protein in the epiphyseal plate cartilage and trabecular bone of growing rats
23. Inhibition of osteoblastogenesis and promotion of osteoblasts and osteocytes by glucocorticoids: Potential mechanisms of their deleterious effects on bone