Studies on the interactions between drug and estrogen. II.1 On the inhibitory effect of 29 drugs reported to induce gynecomastia on the oxidation of estradiol at C-2 or C-17

Biological and Pharmaceutical Bulletin

Volumn 26, Issue 5, 2003, Pages 695-700

  Satoh, Takashi ^a,d   Munakata, Haruka ^c,e   Fujita, Ken Ichi ^b,f   Itoh, Shinji ^a   Itoh, Shungo ^c   Kamataki, Tetsuya ^b   Yoshizawa, Itsuo ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c Japan Seamen Relief Association Otaru Hospital   (Japan)

^d Yakuhan Pharmaceutical Co Ltd   (Japan)

^e Rumoi Municipal Hospital   (Japan)

^f UNIVERSITY OF MIYAZAKI HOSPITAL   (Japan)

Author keywords

Drug induced gynecomastia; Recombinant CYP3A4, estradiol; Type II 17 hydroxysteroid dehydrogenase

Indexed keywords

CHLORMADINONE ACETATE; CYCLOSPORIN A; CYTOCHROME P450 3A4; DOMPERIDONE; ESTRADIOL; FLUTAMIDE; HALOPERIDOL; KETOCONAZOLE; NICARDIPINE; NISOLDIPINE; NITRENDIPINE; OMEPRAZOLE; SPIRONOLACTONE; TACROLIMUS; TESTOSTERONE 17BETA DEHYDROGENASE; VERAPAMIL; ANTIESTROGEN; CYTOCHROME P450; DRUG; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG HYDROXYLATION; GYNECOMASTIA; HUMAN; HUMAN CELL; IC 50; LIVER; MICROSOME; OXIDATION; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COMPARATIVE STUDY; DRUG INTERACTION; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; LIVER MICROSOME; MALE; METABOLISM; OXIDATION REDUCTION REACTION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ESTRADIOL; ESTROGEN ANTAGONISTS; GYNECOMASTIA; HUMANS; HYDROXYLATION; MALE; MICROSOMES, LIVER; OXIDATION-REDUCTION; PHARMACEUTICAL PREPARATIONS; RECOMBINANT PROTEINS;

EID: 1542649526     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.26.695     Document Type: Article

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