A three-component tandem reductive aldol reaction catalyzed by N-heterocyclic carbene-copper complexes

Organic Letters

Volumn 8, Issue 26, 2006, Pages 6059-6062

  Welle, Alexandre ^a   Díez González, Silvia ^b   Tinant, Bernard ^a   Nolan, Steven P ^b   Riant, Olivier ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b INSTITUTE OF CHEMICAL RESEARCH OF CATALONIA ICIQ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARBENE; COPPER; DRUG DERIVATIVE; HETEROCYCLIC COMPOUND; HYDROCARBON; METHANE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; OXIDATION REDUCTION REACTION;

CATALYSIS; COPPER; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; METHANE; MODELS, MOLECULAR; OXIDATION-REDUCTION;

EID: 33846176873     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol062495o     Document Type: Article

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30. Typical Procedure for Tandem Hydrosilylation-Aldolization. A flame-dried flask under argon was loaded with the (NHC)copper complex (0.01 mmol, 0.01 equiv) under argon. A 5 mL portion of freshly distilled toluene was introduced, followed by sequential addition of the electrophilic olefin (1.1 mmol, 1.1 equiv), the electrophile (1 mmol, 1 equiv), and the silane (1.2 mmol, 1.2 equiv). After being stirred for 1 h, the solution was stirred for an additional 1 h under air. The volatile compounds were removed under reduced pressure, and the residue was purified by chromatography on triethylamine- pacified silica gel.