A conjugate reduction-intramolecular aldol strategy toward the synthesis of pseudolaric acid A

Tetrahedron Letters

Volumn 39, Issue 50, 1998, Pages 9229-9232

  Chiu, Pauline ^a   Chen, Bin ^a   Cheng, Kin Fai ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Aldol reactions; Copper and compounds; Natural products

Indexed keywords

ALCOHOL DERIVATIVE; ALDOL; PSEUDOLARIC ACID A; PSEUDOLARIC ACID B; UNCLASSIFIED DRUG;

ARTICLE; CONJUGATION; CYCLIZATION; DIASTEREOISOMER; DRUG SYNTHESIS; REDUCTION; X RAY CRYSTALLOGRAPHY;

EID: 0032506682     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02130-3     Document Type: Article

References (24)

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14. 23
15. 24 yielding 9 as a single diastereomer (eq. 6). Reduction of 9 by Raney-Nickel generated 5b. (equation presented)
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18. 18. When excess Stryker's reagent was used, or when the reaction temperature was raised, 6 and 7 also appear as products.
19. 19. All new compounds were purified and fully characterized by IR, NMR and mass spectral analysis.
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