Bacillus subtilis epoxide hydrolase-catalyzed preparation of enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether and its application to expeditious synthesis of (R)-bicalutamide

Tetrahedron Letters

Volumn 48, Issue 6, 2007, Pages 979-983

  Fujino, Aya ^a   Asano, Masayoshi ^a   Yamaguchi, Hitomi ^b   Shirasaka, Naoki ^b   Sakoda, Akiko ^b   Ikunaka, Masaya ^b   Obata, Rika ^a   Nishiyama, Shigeru ^a   Sugai, Takeshi ^a  

^a KEIO UNIVERSITY   (Japan)

^b Osaka City University Medical School   (Japan)

Author keywords

(R) 1 Benzyloxy 2 methylpropane 2,3 diol; Bicalutamide; Diol; Epoxide hydrolase; Kinetic resolution

Indexed keywords

2 METHYLPROPANE 1,2,3 TRIOL MONOBENZYL ETHER; BENZYL DERIVATIVE; BICALUTAMIDE; EPOXIDE HYDROLASE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; NONHUMAN; RACEMIC MIXTURE;

BACILLUS SUBTILIS;

EID: 33846173011     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.12.011     Document Type: Article

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