Oral administration of metal chelator ameliorates motor dysfunction after a small hemorrhage near the internal capsule in rat

Journal of Neuroscience Research

Volumn 85, Issue 1, 2007, Pages 213-222

  Masuda, Tadashi ^a   Hida, Hideki ^a   Kanda, Yoshie ^a   Aihara, Noritaka ^a   Ohta, Kengo ^a   Yamada, Kazuo ^a   Nishino, Hitoo ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Ferrous iron; Hydroxyl radical; Intracerebral hemorrhage; Oligodendrocyte

Indexed keywords

CLIOQUINOL; FLUOROGOLD; GELATINASE A; HYDROGEN PEROXIDE; IRON CHELATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN HEMORRHAGE; CAPSULA INTERNA; CERVICAL SPINAL CORD; CONTROLLED STUDY; CONVALESCENCE; CORPUS STRIATUM; CYTOTOXICITY; DISEASE SEVERITY; DRUG INHIBITION; DRUG MECHANISM; FUNCTIONAL ASSESSMENT; HISTOPATHOLOGY; IN VITRO STUDY; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE CELL; NERVE FIBER; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PYRAMIDAL TRACT; RAT; SENSORIMOTOR CORTEX;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CELL COUNT; CELLS, CULTURED; CEREBRAL HEMORRHAGE; CHELATING AGENTS; CLIOQUINOL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO; FUNCTIONAL LATERALITY; HYDROGEN PEROXIDE; INTERNAL CAPSULE; MATRIX METALLOPROTEINASE 8; MOTOR ACTIVITY; MOTOR NEURON DISEASE; NEURONS; OLIGODENDROGLIA; PYRAMIDAL TRACTS; RATS; SOMATOSENSORY CORTEX; STILBAMIDINES;

EID: 33846149954     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21089     Document Type: Article

References (36)

1. Altumbabic M, Peeling J, Del Bigio MR. 1998. Intracerebral hemorrhage in the rat effects of hematoma aspiration. Stroke 29:1917-1923.
2. Back SA, Gan X, Li Y, Rosenberg PA, Volpe JJ. 1998. Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. J Neurosci 18:6241-6253.
3. Baud O, Green AE, LiJ, Wang H, Volpe JJ, Rosenberg PA. 2004. Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. J Neurosci 24:1531-1540.
4. Benvenisti-Zarom L, Chen J, Regan RF. 2005. The oxidative neurotoxicity of clioquinol. Neuropharmacology 49:687-694.
5. Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI. 2001. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30:665-676.
6. Chesney JA, Kondoh T, Conrad JA, Low WC. 1995. Collagenase-induced intrastriatal hemorrhage in rats results in long-term locomotor deficits. Stroke 26:312-316.
7. Del Bigio MR, Yan HJ, Buist R, Peeling J. 1996. Experimental intracerebral hemorrhage in rats. Magnetic resonance imaging and histopathological correlates. Stroke 27:2312-2319.
8. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. 1999. Trends Neurosci 22:391-397.
9. Fragoso G, Martinez-Bermudez AK, Liu HN, Khorchid A, Chemtob S, Mushynski WE, Almazan G. 2004. Developmental differences in HO-induced oligodendrocyte cell death: role of glutathione, mitogen-activated protein kinases and caspase 3. J Neurochem 90:392-404.
10. Goldstein L, Teng ZP, Zeserson E, Patel M, Regan RF. 2003. Hemin induces an iron-dependent, oxidative injury to human neuron-like cells. J Neurosci Res 73:113-121.
11. Hains BC, Black JA, Waxman SG. 2003. Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury. J Comp Neurol 462:328-341.
12. Halliwell B. 1992. Reactive oxygen species and the central nervous system. J Neurochem 59:1609-1623.
13. Hida H, Takeda M, Soliven B. 1998. Ceramide inhibits inward rectifying K+ currents via a ras- and raf-1-dependent pathway in cultured oligodendrocytes. J Neurosci 18:8712-8719.
14. Hirrlinger J, Resch A, Gutterer JM, Dringen R. 2002. Oligodendroglial cells in culture effectively dispose of exogenous hydrogen peroxide: comparison with cultured neurons, astroglial and microglial cells. J Neurochem 82:635-644.
15. Huang FP, Xi G, Keep RF, Hua Y, Nemoianu A, Hoff JT. 2002. Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J Neurosurg 96:287-293.
16. Imamura N, Hida H, Aihara N, Ishida K, Kanda Y, Nishino H, Yamada K. 2003. Neurodegeneration of substantia nigra accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage. Neurosci Res 46:289-298.
17. Kaur D, Yantiri F, Rajagopalan S, Kumar J, Mo JQ, Boonplueang R, Viswanath V, Jacobs R, Yang L, Beal MF, DiMonte D, Volitaskis I, Ellerby L, Cherny RA, Bush AI, Andersen JK. 2003. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron 37:899-909
18. Kidani Y, Naga S, Koike H. 1974. Mass spectrometry of 5-chloro-7-iodo-8-quinol metal chelates. Jap Analyst 23:1375-1378.
19. Kotaki H, Nakajima K, Tanimura Y, Saitoh Y, Nakagawa F, Tamura Z, Nagashima K. 1983. Appearance of intoxication in rats by intraperitoneal administration of clioquinol. J Pharmacobiodyn 6:773-783.
20. Kress GJ, Dineley KE, Reynolds IJ. 2002. The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes. J Neurosci 22:5848-5855.
21. Mayne M, Ni W, Yan HJ, Xue M, Johnston JB, Del Bigio MR, Peeling J, Power C. 2001. Antisense oligodeoxynucleotide inhibition of tumor necrosis factor-alpha expression is neuroprotective after intracerebral hemorrhage. Stroke 32:240-248.
22. McCarthy KD, de Vellis J. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85: 890-902.
23. Montaner J, Alvarez-Sabin J, Molina CA, Angles A, Abilleira S, Arenillas J, Monasterio J. 2001. Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke. Stroke 32: 2762-2767.
24. Mronga T, Stahnke T, Goldbaum O, Ritchter-Landsberg C. 2004. Mitochondrial pathway is involved in hydrogen-peroxide-induced apoptotic death of oligodendrocytes. Glia 46:446-455.
25. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G. 2004. Deferoxamine-induced attenuation of brain edema and neurologic deficits in a rat model of intracerebral hemorrhage. J Neurosurg 100:672-678.
26. Padmanabhan G, Becue I, Smith JA. 1989. Clioquinol. In: Klaus E, Florey E, editors. Analytical profiles of drug substances. New York: Academic Press. p 57-90.
27. Peeling J, Yan HJ, Chen SG, Campbell M, Del Bigio MR. 1998. Protective effects of free radical inhibitors in intracerebral hemorrhage in rat. Brain Res 795:63-70.
28. Peeling J, Del Bigio MR, Corbett D, Green AR, Jackson DM. 2001. Efficacy of disodium 4-[(tert-butyl immo)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke. Neuropharmacology 40:433-439.
29. Rosenberg GA, Mun-Bryce S, Wesley M, Kornfeld M. 1990. Collagenase-induced intracerebral hemorrhage in rats. Stroke 21:801-807.
30. Sinar EJ, Mendelow AD, Graham DI, Teasdale GM. 1987. Experimental intracerebral hemorrhage: effects of a temporary mass lesion. J Neurosurg 66:568-576.
31. Suh SW, Chen JW, Motamedi M, Bell B, Listiak K, Pons NF, Danscher G, Frederickson CJ. 2000. Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury. Brain Res 852:268-273.
32. Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF. 2003. Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab 23:629-652.
33. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G. 2003. Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34:2964-2969.
34. Yang GY, Betz AL, Chenevert TL, Brunberg JA, Hoff JT. 1994. Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats. J Neurosurg 81:93-102.
35. Yang Z, Watanabe M, Nishiyama A. 2005. Optimization of oligodendrocyte progenitor cell culture method for enhanced survival. J Neurosci Meth 149:50-56.
36. Youdim MB, Ben-Shachar D, Yehuda S, Riederer P. 1990. The role of iron in the basal ganglion. Adv Neurol 53:155-162.