H1 antihistamines: Psychomotor performance and driving

Journal of Investigational Allergology and Clinical Immunology

Volumn 16, Issue SUPPL. 1, 2006, Pages 37-44

  Jauregui I ^a   Mullol, J ^b   Bartra, J ^b   Del Cuvillo, A ^c   Davila I ^d   Montoro, J ^e   Sastre, J ^f   Valero, A L ^b  

^a HOSPITAL DE BASURTO   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c Clinica Dr Lobaton   (Spain)

^d HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^e HOSPITAL DE LA PLANA   (Spain)

^f Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIVASTINE; ALCOHOL; ANALGESIC AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; CETIRIZINE; CLEMASTINE; DEXCHLORPHENIRAMINE; DIPHENHYDRAMINE; EBASTINE; EMEDASTINE; FEXOFENADINE; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; IMIDAZOLE DERIVATIVE; LEVOCETIRIZINE; LORATADINE; MACROLIDE; MEQUITAZINE; MIZOLASTINE; NEUROLEPTIC AGENT; OPIATE DERIVATIVE; PLACEBO; PSYCHOTROPIC AGENT; RUPATADINE; SEDATIVE AGENT; SEROTONIN UPTAKE INHIBITOR; TERFENADINE; TRICYCLIC ANTIDEPRESSANT AGENT; TRIPROLIDINE;

CAR DRIVING; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; DRIVING ABILITY; DROWSINESS; DRUG ALCOHOL INTERACTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; HUMAN; NEUROPHYSIOLOGY; PREVALENCE; PSYCHOMOTOR PERFORMANCE; REACTION TIME; REVIEW; RHINITIS; RISK FACTOR; SCORING SYSTEM; SEDATION; SIDE EFFECT; SINGLE DRUG DOSE; TRAFFIC ACCIDENT; URTICARIA; CROSS-SECTIONAL STUDY; TASK PERFORMANCE;

AUTOMOBILE DRIVING; CROSS-SECTIONAL STUDIES; HISTAMINE H1 ANTAGONISTS; HUMANS; PSYCHOMOTOR PERFORMANCE; REACTION TIME; TASK PERFORMANCE AND ANALYSIS;

EID: 33846090712     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Review

References (25)

1. González Luque JC. Accidentalidad por tráfico en España. En Álvarez FJ, del Río MC: Antihistamínicos H1 y conducción de vehículos. Ed. Masson. Barcelona, 1998.
2. Añíbarro B, Seoane FJ: Seguridad vial y enfermedad alérgica. Alergol Inmunol Clin 2005; 20: 232-237.
3. Simons FER: Advances in H1-Antihistamines. N Eng J Med 2004; 351:2203-2217.
4. Barbanoj MJ, Antonijoan RM, García-Gea C, Massana E, Jané F: Bases neurobioquímicas del efecto central de los antihistamí nicos. En Álvarez FJ, del Río MC: Antihistamínicos H1 y conducción de vehículos. Ed. Masson. Barcelona, 1998.
5. Jutel M, Blaser K, Akdis CA. Histamine in chronic allergic responses. J Invest Allergol Clin Immunol 2005;15:1-8.
6. Leurs R, Church MK, Taglialatela M. H1-antihistamines: Inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy 2002; 32:489-498.
7. Walsh GM, Annunziato L, Frossard N, Knol K, Levander S, Nicolas JM, Tagliatatela M, Tharp M, Tillement J, Timmerman H. New insights into the second generation antihistamines. Drugs 2001; 61:207-236.
8. Ten Eick AP, Blumer JL, Reed MD: Safety of antihistamines in children. Drug Safety 2001; 24:119-147.
9. Tashiro M, Sakurada Y, Iwabuchi K, Mochizuki H, Kato M, 44 Aoki M, Funaki Y, Itoh M, Iwata R, Wong DF, Yanai K. Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol 2004;44:890-900.
10. Welch MJ, Meltzer EO, Simons FER: H1-Antihistamines and the Central Nervous System. En: Histamine and H1-Antihistamines in Allergic Disease, 2nd Ed., edit. por Simons FER. Marcel Dekker, New York, 2002.
11. Holgate ST, Canonica GW, Simons FER, Taglialatela M, Tharp M, Timmerman H, Yanai K. Consensus group on newgeneration antihistamines (CONGA): present status and recommendations. Clin Exp Allergy 2003; 33:1305-1324.
12. Hindmarch I, Shamsi Z. Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects. Clin Exp Allergy 1999; 29 (Suppl 3): 133-142.
13. Simons FER, Fraser TG, Reggin JD, Roberts JR, Simons KJ: Adverse central nervous system effects of older antihistamines in children. Pediatr Allergy Immunol 1996; 7:22-27.
14. Golightly LK, Greos LS: Second-generation antihistamines actions and efficacy in the management of allergic disorders. Drugs 2005; 65: 341-384.
15. Del Río Gracia MC, Alvarez González FJ: Factores que influyen en el efecto de los fármacos sobre la capacidad de conducción. En Álvarez FJ, del Río MC: Antihistamí nicos H1 y conducción de vehículos. Ed. Masson. Barcelona, 1998.
16. Moskowitz H, Wilkinson CJ: Antihistamines and drivingrelated behaviour. A review of the evidence for impairment. US Department of Transportation. National Highway Traffic Safety Administration. Washington DC, 1998.
17. Nicholson AN, Handford ADF, Turner C, Stone BM. Studies on performance and sleepiness with the H1-antihistamine desloratadine. Aviat Space Environ Med 2003; 74:809-815.
18. O'Hanlon JF. Driving performance under the influence of drugs: rationale for, and application of a new test. Br J Clin Pharmacol 1984;18:121S-129S.
19. Verster JC, Volkerts ER: Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic. Ann Allergy Asthma Immunol 2004;92:294-304.
20. de Waard D, Brookhuis KA: Drug Effects on Driving Performance. Ann Int Med 2000; 133:656.
21. Vermeeren A, Ramaekers JG, O'Hanlon JF: Effects of emedastine and cetirizine, alone and with alcohol, on actual driving of males and females. J Psychopharmacol 2002; 16:57-64.
22. Ramaekers JG, Uiterwijk MM, O'Hanlon JF: Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving. Eur J Clin Pharmacol 1992; 42:363-369.
23. Sussman GL, Mason J, Compton D, Stewart J, Ricard N: The efficacy and safety of fexofenadine HCl and pseudoephedrine, alone and in combination, in seasonal allergic rhinitis. J Allergy Clin Immunol 1999; 104:100-106.
24. Simons FER, Gu X, Watson WT, Simons KJ. Pharmacokinetics of the orally administered decongestants pseudoephedrine and phenylpropanolamine in children. J Pediatr 1996; 129: 729-734.
25. Verster JC, Volkerts ER, van Oosterwijck AW, Aarab M, Bijtjes SI, De Weert AM, Eijken EJ, Verbaten MN. Acute and subchronic effects of levocetirizine and dyphenhydramine on memory functioning, psychomotor performance, and mood. J Allergy Clin Immunol 2003; 111:623-627