Adverse central nervous system effects of older antihistamines in children

Pediatric Allergy and Immunology

Volumn 7, Issue 1, 1996, Pages 22-27

  Simons, F Estelle R ^a,c   Fraser, Terry G ^b   Reggin, James D ^a   Roberts, Janet R ^a   Simons, Keith J ^b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c NONE   (Canada)

Author keywords

Allergic rhinitis; Antihistamine; Diphenhydramine; H1 receptor antagonist; Hydroxyzine; P300 latency

Indexed keywords

ANTIHISTAMINIC AGENT; DIPHENHYDRAMINE; HISTAMINE H1 RECEPTOR; HYDROXYZINE;

ALLERGIC RHINITIS; ARTICLE; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; COGNITION; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; HUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING;

EID: 0029948090     PISSN: 09056157     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3038.1996.tb00101.x     Document Type: Article

References (31)

1. SAMPSON HA, EGGLESTON PA. Allergy. In: OSKI FA, DEANGELIS CD, FEIGIN RD, MCMILLAN JA, WARSHAW JB, eds. Principles and practice of pediatrics. Philadelphia, PA: JB Lipincott, 1994: 209-43.
2. VUURMAN EFPM, VAN VEGGEL LMA, UITERWIJK MMC, LEUTNER D, O'HANLON JF. Seasonal allergic rhinitis and antihistamine effects on children's learning. Ann Allergy 1993: 71: 121-6.
3. FELDMAN W, SHANON A, LEIKEN L, HAM-PONG A, PETERSON R. Central nervous system side-effects of antihistamines in schoolchildren. Rhinology 1992: 13 (Suppl.): 13-19.
4. 1-receptor antagonists) terfenadine and chlorpheniramine in children. J Pediatr 1994: 124: 979-83.
5. 1-antihistamines. Ann Allergy 1991: 67: 625-33.
6. 1-receptor antagonists. Comparative tolerability and safety. Drug Safety 1994: 10: 350-80.
7. 1-receptor antagonists. Clin Exp Allergy 1994: 24: 707-23.
8. ROMBAUT NEI, HINDMARCH I. Psychometric aspects of antihistamines: a review. Hum Psychopharmacol Clin Exp 1994: 9: 157-69.
9. KROGH CME, GILLIS MC, eds. Compendium of pharmaceuticals and specialties. Ottawa, Ontario: Canadian Pharmaceutical Association, 1995: 123-4, 157-8.
10. 1-receptor antagonists loratadine and terfenadine versus placebo in children. J Pediatr 1991: 118: 298-300.
11. SIMONS KJ, WATSON WTA, MARTIN TJ, CHEN XY, SIMONS FER. Diphenhydramine: pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children. J Clin Pharmacol 1990: 30: 665-71.
12. SIMONS FER, SIMONS KJ, BECKER AB, HAYDEY RP. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis. J Pediatr 1984: 104: 123-7.
13. POUCH J. P300 in clinical applications: meaning, method and measurement. Am J EEG Technol 1991: 31: 201-31.
14. FINLEY WW, FAUX SF, HUTCHESON J, AMSTUTZ L. Long-latency event-related potentials in the evaluation of cognitive function in children. Neurology 1985: 35: 323-7.
15. FUCHIGAMI T, OKUBO O, FUJITA Y, OKUNI M, NOGUCHI Y, YAMADA T. Auditory event-related potentials and reaction time in children: evaluation of cognitive development. Dev Med Child Neurol 1993: 35: 230-7.
16. OTSUKA T, SUNAGA Y, NAGASHIMA K, KUROUME T. Correlation in children between P300 latency and scores on the Weschler Intelligence Scale for Children-revised. Am J EEG Technol 1993: 33: 49-58.
17. ROTH T, ROEHRS T, KOSHOREK G, SICKLESTEEL J, ZORICK F. Sedative effects of antihistamines. J Allergy Clin Immunol 1987: 80: 94-8.
18. NETER J, WASSERMAN W, KUTNER MH. Applied linear statistical models. Boston, MA: Irwin, 1993: 517-67.
19. MAGERA BE, BETLACH CJ, SWEATT AP, DERRICK CW Jr. Hydroxyzine intoxication in a 13-month-old child. Pediatrics 1981: 67: 280-3.
20. WYNGAARDEN JB, SEEVERS MH. The toxic effects of antihistaminic drugs. JAMA 1951: 145: 277-82.
21. REILLY JF Jr, WEISSE ME. Topically induced diphenhydramine toxicity. J Emerg Med 1990: 8: 59-61.
22. RUSSO RM, GURURAJ VJ, ALLEN JE. The effectiveness of diphenhydramine HCl in pediatric sleep disorders. J Clin Pharmacol 1976: 16: 284-8.
23. KOREIN J, FISH B, SHAPIRO T, GERNER EW, LEVIDOW L. EEG and behavioral effects of drug therapy in children. Chlorpromazine and diphenhydramine. Arch Gen Psychiatry 1971: 24: 552-63.
24. KAPETANSKY D, WARREN R, HAWTOF D. Cleft lip repair using intramuscular hydroxyzine sedation and local anesthesia. Cleft Palate Craniofac J 1992: 29: 481-4.
25. FRANSSEN C, HANS P, BRICHANT JF, NOIROT D, LAMY M. Comparison between alprazolam and hydroxyzine for oral premedication. Can J Anaesth 1993: 40: 13-17.
26. 11C]pyrilamine and positron emission tomography. J Neurochem 1992: 59: 128-36.
27. 1-receptor activation reduces a background leakage potassium current. Neuroscience 1994: 59: 579-88.
28. 1-blockers. In: CHURCH MK, RIHOUX J-P, eds. Therapeutic index of antihistamines. Lewiston, NY: Hogrefe & Huber, 1992: 19-31.
29. SNYDER SH, SNOWMAN AM. Receptor effects of cetirizine. Ann Allergy 1987: 59: 4-8.
30. ANONYMOUS. New advertisements for an old antihistamine. Med Lett 1993: 35: 9-10.
31. 1-receptor antagonist drugs. N Engl J Med 1994: 330: 1663-70.