Pulmonary vascular reactivity of spontaneously hypertensive rats is exacerbated in response to the central administration of exogenous nitric oxide

Clinical and Experimental Pharmacology and Physiology

Volumn 34, Issue 1-2, 2007, Pages 88-94

  Schwenke, Daryl O ^a   Pearson, James T ^b   Tsuchimochi, Hirotsugu ^c   Kangawa, Kenji ^a   Shirai, Mikiyasu ^d  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b YAMAGUCHI UNIVERSITY   (Japan)

^c HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^d MONASH UNIVERSITY   (Australia)

Author keywords

Hypertensive rats; Hypoxic pulmonary vasoconstriction; Nitric oxide; Sympathetic nervous system

Indexed keywords

LINSIDOMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONOR; OXYGEN; PENTOBARBITAL;

ADRENERGIC SYSTEM; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DISEASE EXACERBATION; ELECTROPHYSIOLOGY; ESSENTIAL HYPERTENSION; HEART OUTPUT; HEART RATE; HYPOTHESIS; HYPOXIA; HYPOXIC LUNG VASOCONSTRICTION; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG VASCULAR RESISTANCE; MALE; MEAN ARTERIAL PRESSURE; NITRERGIC NERVE; NONHUMAN; PRESSOR RESPONSE; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ANIMALS; ANOXIA; AORTA; BLOOD PRESSURE; CARDIAC OUTPUT; ENZYME INHIBITORS; HYPERTENSION; MALE; MOLSIDOMINE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; PULMONARY ARTERY; PULMONARY CIRCULATION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 33846080090     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04544.x     Document Type: Article

References (35)

1. Garthwaite J, Boulton CL. Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 1995; 57: 683-706.
2. Matsumura K, Tsuchihashi T, Kagiyama S, Abe I, Fujishima M. Role of nitric oxide in the nucleus of the solitary tract of rats. Brain Res. 1998; 798: 232-8.
3. Zanzinger J, Czachurski J, Seller H. Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide. Am. J. Physiol. 1995; 268: R958-62.
4. Ohta A, Takagi H, Matsui T, Hamai Y, Iida S, Esumi H. Localization of nitric oxide synthase-immunoreactive neurons in the solitary nucleus and ventrolateral medulla oblongata of the rat: Their relation to catecholaminergic neurons. Neurosci. Lett. 1993; 158: 33-5.
5. Hironaga K, Hirooka Y, Matsuo I et al. Role of endogenous nitric oxide in the brain stem on the rapid adaptation of baroreflex. Hypertension 1998; 31: 27-31.
6. Nishimura M, Takahashi H, Nanbu A, Sakamoto M, Yoshimura M. Cardiovascular regulation by l-arginine in the brain of rats: Role of the brain renin-angiotensin system and nitric oxide. Am. J. Hypertens. 1997; 10: 389-96.
7. Harada S, Tokunaga S, Momohara M et al. Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits. Circ. Res. 1993; 72: 511-16.
8. Togashi H, Sakuma I, Yoshioka M et al. A central nervous system action of nitric oxide in blood pressure regulation. J. Pharmacol. Exp. Ther. 1992; 262: 343-7.
9. Shapoval LN, Sagach VF, Pobegailo LS. Nitric oxide influences ventrolateral medullary mechanisms of vasomotor control in the cat. Neurosci. Lett. 1991; 132: 47-50.
10. Patel KP, Li YF, Hirooka Y. Role of nitric oxide in central sympathetic outflow. Exp. Biol. Med. 2001; 226: 814-24.
11. Lai LT, Brody MJ. Vasoconstrictor hyperresponsiveness: An early pathogenetic mechanism in the spontaneously hypertensive rat. Eur. J. Pharmacol. 1978; 17: 178-89.
12. Judy WV, Watanabe AM, Henry DP, Besch Jr HR, Murphy WR, Hockel GM. Sympathetic nerve activity: Role in regulation of blood pressure in the spontaenously hypertensive rat. Circ. Res. 1976; 38 (Suppl. 2): 21-9.
13. Brody MJ, Varner KJ, Vasquez EC, Lewis SJ. Central nervous system and the pathogenesis of hypertension. Sites and mechanisms. Hypertension 1991; 18 (Suppl. 5): 7-12.
14. Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H, Takeshita A. Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release. Hypertension 2001; 38: 896-901.
15. Kagiyama S, Tsuchihashi T, Abe I, Fujishima M. Enhanced depressor response to nitric oxide in the rostral ventrolateral medulla of spontaneously hypertensive rats. Hypertension 1998; 31: 1030-4.
16. El Karib AO, Sheng J, Betz AL, Malvin RL. The central effects of a nitric oxide synthase inhibitor (Nw-nitro-l-arginine) on blood pressure and plasma renin. Clin. Exp. Hypertens. 1993; 15: 819-32.
17. Schleiffer R, Pernot F, Van Overloop B, Gairard A. In vivo involvement of endothelium-derived nitric oxide in spontaneously hypertensive rats: Effects of NG-nitro-l-arginine methyl ester. J. Hypertens. 1991; 9 (Suppl. 6): S192-3.
18. Cabrera CL, Bealer SL, Bohr DF. Central depressor action of nitric oxide is deficient in genetic hypertension. Am. J. Hypertens. 1996; 9: 237-41.
19. Kishi T, Hirooka Y, Ito K, Sakai K, Shimokawa H, Takeshita A. Cardiovascular effects of overexpression of endothelial nitric oxide synthase in the rostral ventrolateral medulla in stroke-prone spontaneously hypertensive rats. Hypertension 2002; 39: 264-8.
20. Janssens SP, Thompson BT, Spence CR, Hales CA. Functional and structural changes with hypoxia in pulmonary circulation of spontaneously hypertensive rats. J. Appl. Physiol. 1994; 77: 1101-7.
21. Sekiguchi F, Yamamoto K, Matsuda K et al. Endothelium-dependent relaxation in pulmonary arteries of l-NAME-treated Wistar and stroke-prone spontaneously hypertensive rats. J. Smooth Muscle Res. 2002; 38: 131-44.
22. McMurtry IF, Petrun MD, Tucker A, Reeves JT. Pulmonary vascular reactivity in the spontaneously hypertensive rat. Blood Vessels 1979; 16: 61-70.
23. Paxinos G, Watson C. The Brain in Stereotaxic Coordinates, 4th edn. Academic Press, San Diego. 1998.
24. Schwenke DO, Pearson JT, Tsuchimochi H, Mori H, Shirai M. Exogenous nitric oxide centrally enhances pulmonary reactivity in the normal and hypertensive rat. Clin. Exp. Pharmacol. Physiol. 2005; 32: 952-9.
25. Choi KC, Jung M, Lee JU, Kim SW, Kim NH, Kang YJ. Attenuated central pressor response to nitric oxide synthesis inhibition in chronic renal failure rats. Korean J. Intern. Med. 1997; 12: 58-61.
26. Nurminen ML, Ylikorkala A, Vapaatalo H. Central inhibition of nitric oxide synthesis increases blood pressure and heart rate in anesthetized rats. Methods Find. Exp. Clin. Pharmacol. 1997; 19: 35-41.
27. Zanzinger J, Czachurski J, Seller H. Nitric oxide in the ventrolateral medulla regulates sympathetic responses to systemic hypoxia in pigs. Am. J. Physiol. 1998; 275: R33-9.
28. Shirai M, Shindo T, Ninomiya I. Beta-Adrenergic mechanisms attenuated hypoxic pulmonary vasoconstriction during systemic hypoxia in cats. Am. J. Physiol. 1994; 266: H1777-85.
29. Brimioulle S, Vachiery JL, Brichant JF, Delcroix M, Lejeune P, Naeije R. Sympathetic modulation of hypoxic pulmonary vasoconstriction in intact dogs. Cardiovasc. Res. 1997; 34: 384-92.
30. Morrison SF. Differential control of sympathetic outflow. Am. J. Physiol. Regul. Intergr. Comp. Physiol. 2001; 281: R683-98.
31. Shirai M, Matsukawa K, Nishiura N, Kawaguchi AT, Ninomiya I. Changes in efferent pulmonary sympathetic nerve activity during systemic hypoxia in anesthetized cats. Am. J. Physiol. 1995; 269: R1404-9.
32. Nurminen ML, Vapaatalo H. Effect of intracerebroventricular and intravenous administration of nitric oxide donors on blood pressure and heart rate in anaesthetized rats. Br. J. Pharmacol. 1996; 119: 1422-6.
33. Stopper H, Moller M, Bommel HM, Schmidt HH. Cytotoxic versus genotoxic effects of nitric oxide (NO). Toxicol. Lett. 1999; 106: 59-67.
34. Megson IL, Webb DJ. Nitric oxide donor drugs: Current status and future trends. Expert Opin. Invest. Drugs 2002; 11: 587-601.
35. Gao L, Wang W, Li YL et al. Superoxide mediates sympathoexcitation in heart failure: Roles of angiotensin II and NAD(P)H oxidase. Circ. Res. 2004; 95: 937-44.