Endothelium-dependent relaxation in pulmonary arteries of L-NAME-treated Wistar and stroke-prone spontaneously hypertensive rats

Journal of Smooth Muscle Research

Volumn 38, Issue 4-5, 2002, Pages 131-144

  Sekiguchi, Fumiko ^a   Yamamoto, Kazuo ^a   Matsuda, Kyoko ^a   Kawata, Kyoko ^a   Negishi, Maki ^a   Shinomiya, Kazuaki ^a   Shimamura, Keiichi ^b   Sunano, Satoru ^a  

^a KINKI UNIVERSITY   (Japan)

^b HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

Chronic L NAME treatment; Endothelium dependent relaxation (EDR); Pulmonary arterial blood pressure; Pulmonary artery; Stroke prone spontaneously hypertensive rats (SHRSP)

Indexed keywords

ACETYLCHOLINE; ARGININE; CHLORALOSE; EDETATE CALCIUM DISODIUM; ENDOTHELIUM DERIVED RELAXING FACTOR; INDOMETACIN; N(G) NITRO DEXTRO ARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; NORADRENALIN; PAPAVERINE; URETHAN; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; CONVALESCENCE; ENDOTHELIUM; ENDOTHELIUM CELL; ENDOTHELIUM DEPENDENT RELAXATION; ENZYME INHIBITION; EVALUATION; LONG TERM EXPOSURE; LUNG ARTERY PRESSURE; MALE; NONHUMAN; PULMONARY ARTERY; RAT; SMOOTH MUSCLE RELAXATION; SPONTANEOUSLY HYPERTENSIVE RAT; STATISTICAL SIGNIFICANCE; STRAIN DIFFERENCE; STROKE; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ARGININE; BLOOD PRESSURE; BODY WEIGHT; CARDIOVASCULAR AGENTS; CEREBROVASCULAR ACCIDENT; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GENETIC PREDISPOSITION TO DISEASE; HYPERTENSION; INDOMETHACIN; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE DONORS; NITROARGININE; NITROPRUSSIDE; PULMONARY ARTERY; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, WISTAR; VASODILATION;

EID: 0036825669     PISSN: 09168737     EISSN: None     Source Type: Journal    
DOI: 10.1540/jsmr.38.131     Document Type: Article

References (44)

1. Aharinejad, S., Schraufnagel, D.E., Böck, P., MacKay, C.A., Larson, E.K., Miksovsky, A. and Marks, Jr. S.C. (1996). Spontaneously hypertensive rats develop pulmonary hypertension and hypertrophy of pulmonary venous sphincters. Am. J. Pathol. 148: 281-290.
2. Aisaka, K., Gross, S.S., Griffith, O.W. and Levi, R. (1989). L-Arginine availability determines the duration of acetylcholine-induced systemic vasodilatation in vivo. Biochem. Biophys. Res. Commun. 163: 710-717.
3. Alosachie, I. and Godfraind, T. (1988). The modulatory role of vascular endothelium in the interaction of agonists and antagonists with alpha-adrenoceptors in the rat aorta. Br. J. Pharmacol. 95: 619-629.
4. Altiere, R.J., Olson, J.W. and Gillespie, N.N. (1986). Altered pulmonary vascular smooth muscle responsiveness in monocrotaline-induced pulmonary hypertension. J. Pharmacol. Exp. Ther. 236: 390-395.
5. Arnal, J.F., el Amrani, A.I., Chatellier, G., Ménard, J. and Michel J.B. (1993). Cardiac weight in hypertension induced by nitric oxide synthase blockade. Hypertension 22: 380-387.
6. Arnal, J.F., Warin, L. and Michel, J.B. (1992). Determinant of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase. J. Clin. Invest. 90: 647-652.
7. Baylis, C., Mitruka, B. and Deng, A. (1992). Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damages. J Clin. Invest. 90: 278-281.
8. G-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responses. Br. J. Pharmacol. 114: 1673-1679.
9. Clozel, M., Kuhn, H. and Hefti, F. (1990). Effects of angiotensin converting enzyme inhibitors and of hydralazine on endothelial function in hypertensive rats. Hypertension 16: 532-540.
10. Diederich, D., Yang, Z., Bühler, F.R. and Lüscher, T.F. (1990). Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway. Am. J. Physiol. 258: H445-H451.
11. Dohi, Y., Criscione, L., Pfeiffer, K. and Lüscher, T.F. (1994). Angiotensin blockade or calcium antagonists improve endothelial dysfunction in hypertension: Studies in perfused mesenteric resistance arteries. J. Cardiovasc. Pharmacol. 24: 372-379.
12. Dowell, F.J., Henrion, D., Duriez, M. and Mishcel, J.-B. (1996). Vascular reactivity in mesenteric resistance arteries following chronic nitric oxide synthase inhibition in Wistar rats. Br. J. Pharmacol. 117:341-346.
13. Gardiner, S.M., Compton, A.M., Bennett, T., Palmer, R.M. and Moncada, S. (1990a). Control of regional blood flow by endothelium-derived nitric oxide. Hypertension 15: 486-492.
14. G-nitro-L-arginine methyl ester in conscious, Long Evans rats. Br. J. Pharmacol. 101: 625-631.
15. Hayes, B.E. and Will, J.A. (1978). Pulmonary artery catheterization in the rat. Am. J. Physiol. 235: H452-H454.
16. Henrion, D., Dechaux, E., Dowell, F.J., Maclour, J., Samuel, J.-L., Levy, B.I. and Michel, J.-B. (1997). Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2. Br. J. Pharmacol. 121: 83-90.
17. Ignarro, L.J. (1989). Endothelium-derived nitric oxide: actions and properties. FASEB J. 3: 31-36.
18. Ito, K., Nakashima, T., Murakami, K. and Murakami, T. (1988). Altered function of pulmonary endothelium following monocrotaline-induced lung vascular injury in rats. Br. J. Pharmacol. 94: 1175-1183.
19. Kaneko, K. and Sunano, S. (1993). Involvement of alpha-adrenoceptors in the endothelium-dependent depression of noradrenaline-induced contraction in rat aorta. Eur. J. Pharmacol. 240: 195-200.
20. Küng, C.F., Moreau, P., Takase, H. and Lüscher, T.F. (1995). L-NAME hypertension alters endothelial and smooth muscle function in rat aorta. Prevention by trandolapril and verapamil. Hypertension 26: 744-751.
21. ω-nitro-L-arginine methyl ester affects blood pressure and cardiovascular structure in the genetically hypertensive rat strain. Clin. Exp. Pharmacol. Physiol. 24: 433-435.
22. Lüscher, T.F. and Vanhoutte, P.M. (1990). The endothelium: modulator of cardiovascular function, CRC Press, Boca Raton, FL, USA.
23. Martin, W., Smith, J.A. and White, D.G. (1986). The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide, or bovine retractor penis inhibitory factor. Br. J. Pharmacol. 89: 563-571.
24. Matsuda, K. Sekiguchi, F. Yamamoto, K. Shimamura, K. and Sunano, S. (2000). Unaltered endothelium-dependent modulation of contraction in the pulmonary artery of hypertensive rats. Eur. J. Pharmacol. 392: 61-70.
25. Mizuno, K., Yamamoto, S. and Lands, W.E. (1982). Effects of non-steroidal anti-inflammatory drugs on fatty acid cyclooxygenase and prostaglandin hydroperoxidase activities. Prostaglandins 23: 743-757.
26. Moncada, S., Palmer, R.M.J. and Higgs, E.A. (1991). Nitric oxide physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109-142.
27. G-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br. J. Pharmacol. 99: 408-412.
28. Moreau, P., Takase, H., d'Uscio, L.V. and Ltischer, T.F. (1998). Effect of chronic nitric oxide deficiency on angiotensin II-induced hypertrophy of rat basilar artery. Stroke 29: 1031-1036.
29. Nakazawa, H., Hori, M., Ozaki, H. and Karaki, H. (1999). Mechanisms underlying the impairment of endothelium-dependent relaxation in the pulmonary artery of monocrotaline-induced pulmonary hypertensive rats. Br. J. Pharmacol. 128: 1098-1104.
30. Needleman, P., Turk, J., Jakschik, B.A., Morrison, A.R. and Lefkowith, J.B. (1986). Arachidonic acid metabolism. Ann. Rev. Biochem. 55:69-102.
31. Osugi, S., Shimamura, K. and Sunano, S. (1990). Decreased modulation by endothelium of noradrenaline-induced contractions in aorta from stroke-prone spontaneously hypertensive rats. Arch Int. Pharmacodyn Ther. 305: 86-99.
32. Palmer, R.M.J., Rees, D.D., Ashton, D.S. and Moncada, S. (1988). L-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem. Biophys, Res. Commun. 153: 1251-1256.
33. G-nitro-L-arginine. Br. J. Pharmacol. 118: 1433-1440.
34. Rapoport, R.M. and Murad, F. (1983). Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res. 52: 352-357.
35. Rees, D.D., Palmer, R.M.J., Schulz, R., Hodson, H.F. and Moncada, S. (1990). Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101: 746-752.
36. Ribeiro, M.O., Antunes, E., de Nucci, G., Lovisolo, S.M. and Zatz, R. (1992). Chronic inhibition of nitric oxide synthesis: a new model of arterial hypertension. Hypertension 20: 298-303.
37. Sekiguchi, F., Miyake, Y., Hirakawa, A., Nakahira, T., Yamamoka, M., Shimamura, K., Yamamoto, K. and Sunano, S. (2001). Hypertension and impairment of endothelium-dependent relaxation of arteries from spontaneously hypertensive and L-NAME-treated Wistar rats. J. Smooth Muscle Res. 37: 67-79.
38. Shimamura, K., Sekiguchi, F., Matsuda, K., Yamamoto, K., Tanaka, S., Sunano, S., Shibutani, T., Hashimoto, H. and Tanaka, M. (1998). Membrane potential of mesenteric artery from carvedilol-treated spontaneously hypertensive rats. Eur. J. Pharmacol. 344: 161-168.
39. Shimokawa, H. and Takeshita, A. (1995). Endothelium-dependent regulation of the cardiovascular system. Intern. Med. 34: 939-946.
40. Stinger, R.B., Iacopino, V.J., Alter, I., Fitzpatrick, T.M., Rose, J.C. and Kot, P.A. (1981). Catheterization of the pulmonary artery in the closed-chest rat. J. Appl. Physiol. 51: 1047-1050.
41. Sunano, S., Itoh, H., Isogai, N., Osugi, S., Yamamoto, K. and Shimamura, K. (1993). Effects of antihypertensive treatment on endothelial structure and endothelium-dependent relaxation in aortae of stroke-prone spontaneously hypertensive rats. J. Vasc. Medicine Biol. 4: 235-242.
42. Sunano, S., Osugi, S., Kaneko, K., Yamamoto, K. and Shimamura, K. (1992). Effects of chronic treatment with SQ29852 on spontaneous smooth muscle tone and endothelium-dependent relaxation in aorta of stroke-prone spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 19: 602-609.
43. Takase, H., Moreau, P., Küng, C.F., Nava, E. and Liischer, T.F. (1996). Antihypertensive therapy prevents endothelial dysfunction in chronic nitric oxide deficiency. Effect of verapamil and trandolapril. Hypertension 27: 25-31.
44. ω-nitro-L-arginine methyl ester are not solely mediated by inhibition of endothelial nitric oxide synthesis in the rat mesenteric artery. J. Cardiovasc. Pharmacol. 33: 554-566.