Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts

Cardiovascular Research

Volumn 73, Issue 3, 2007, Pages 488-496

  Pierre, Sandrine V ^a   Yang, Changjun ^a   Yuan, Zhaokan ^a   Seminerio, Jennifer ^a   Mouas, Christian ^b   Garlid, Keith D ^c   Dos Santos, Pierre ^b   Xie, Zijian ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b INSERM   (France)

^c PORTLAND STATE UNIVERSITY   (United States)

Author keywords

Ischemia; Na K pump; Reperfusion; Signal transduction

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); LACTATE DEHYDROGENASE; OUABAIN; PHOSPHOLIPASE C GAMMA1; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; HEART FUNCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; ISCHEMIC PRECONDITIONING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ENZYME ACTIVATION; ENZYME INHIBITORS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; L-LACTATE DEHYDROGENASE; MALE; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; PERFUSION; PROTEIN KINASE C-EPSILON; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 33846074889     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2006.11.003     Document Type: Article

References (48)

1. Skou J.C. Nobel lecture. The identification of the sodium pump. Biosci Rep 18 (1998) 155-169
2. +-ATPase. J Biol Chem 263 (2002) 19659-19662
3. +-ATPase. Annu Rev Biochem 71 (2002) 511-535
4. +-ATPase-mediated signal transduction: from protein interaction to cellular function. Mol Interv 3 (2003) 157-168
5. +-ATPase. Am J Physiol Cell Physiol 284 (2003) C1550-C1560
6. +-ATPase. J Biol Chem 279 (2004) 17250-17259
7. Liu L., Abramowitz J., Askari A., and Allen J.C. Role of caveolae in ouabain-induced proliferation of cultured vascular smooth muscle cells of the synthetic phenotype. Am J Physiol Heart Circ Physiol 287 (2004) H2173-H2182
8. +-ATPase forms a functional signaling complex. Mol Biol Cell 17 (2006) 317-326
9. +-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex. Mol Biol Cell 16 (2005) 4034-4045
10. +-ATPase to ERK 1/2. J Biol Chem 276 (2001) 42050-42056
11. +-ATPase to ERK1/2. J Cardiovasc Pharmacol 41 (2003) 609-614
12. Armstrong S.C. Protein kinase activation and myocardial ischemia/reperfusion injury. Cardiovasc Res 61 (2004) 427-436
13. Munakata M., Stamm C., Friehs I., Zurakowski D., Cowan D.B., Cao-Danh H., et al. Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidil-inositol specific phospholipase C. Ann Thorac Surg 73 (2002) 12236-12245
14. Baines C.P., Zhang J., Wang G.W., Zheng Y.T., Xiu J.X., Cardwell E.M., et al. Mitochondrial PKCε and MAPK form signaling modules in the murine heart. Enhanced mitochondrial PKCε-MAPK interactions and differential MAPK activation in PKCε-induced cardioprotection. Circ Res 90 (2002) 390-397
15. Inagaki K., Hahn H.S., Dorn II G.W., and Mochly-Rosen D. Additive protection of the ischemic heart ex vivo by combined treatment with δ-protein kinase C inhibitor and ε-protein kinase C activator. Circulation 108 (2003) 869-875
16. McCarthy J., McLeod C.J., Minners J., Essop M.F., Ping P., and Sack M.N. PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve-a putative mechanism in PKCepsilon cardioprotection. J Mol Cell Cardiol 38 (2005) 697-700
17. Sutherland F.J., Shattock M.J., Baker K.E., and Hearse D.J. Mouse isolated perfused heart: characteristics and cautions. Clin Exp Pharmacol Physiol 30 (2003) 867-878
18. Favereau X., Dunica S., Chevalier B., Mouas C., and Swynghedeauw B. The antagonistic effects of ouabain and calcium channel blockers on the contractility of the isolated rat heart. J Pharmacol 17 (1986) 651-656
19. Kennedy D.J., Vetteth S., Periyasamy S.M., Kanj M., Fedorova L., Khouri S., et al. Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension 47 (2006) 488-495
20. Ytrehus K., Liu Y., Tsuchida A., Miura T., Liu G.S., Yang X.M., et al. Rat and rabbit heart infarction: effects of anesthesia, perfusate, risk zone, and method of infarct sizing. Am J Physiol 267 (1994) H2383-H2390
21. Bae S., and Zhang L. Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling. J. Pharmacol. Exp. Ther. 315 (2005) 1125-1135
22. Murry C.E., Jennings R.B., and Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74 (1986) 1124-1136
23. Dos Santos P., Kowaltowski A.J., Laclau M.N., Seetharaman S., Paucek P., Boudina S., et al. Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart. Am J Physiol Heart Circ Physiol 283 (2002) H284-H295
24. Penna C., Alloatti G., Cappello S., Gattullo D., Berta G., Mognetti B., et al. Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation. Am J Physiol Heart Circ Physiol 288 (2005) H2512-H2520
25. Xu Z.L., Endoh H., Ishihata A., Takahashi E., and Doi K. Effect of ischemic preconditioning on myocardial oxygen consumption during ischemia. J Mol Cell Cardiol 30 (1998) 2165-2174
26. +-ATPase in hearts. Am J Physiol Heart Circ Physiol 285 (2003) H1055-H1063
27. Harrison G.J., Willis R.J., and Headrick J.P. Extracellular adenosine levels and cellular energy metabolism in ischemically preconditioned rat heart. Cardiovasc Res 40 (1998) 74-87
28. +-ATPase and cardiac glycoside binding. J Clin Invest 57 (1976) 341-350
29. +-ATPase. Am J Physiol 252 (1987) H252-H257
30. +-ATPase activity during early reperfusion contributes to cell death after myocardial ischemia. Circ Res 97 (2005) 465-473
31. Bersohn M.M. Sodium pump inhibition in sarcolemma from ischemic hearts. J Mol Cell Cardiol 27 (1995) 1483-1489
32. +-ATPase. FASEB J 18 (2004) 197-199
33. 2+-ATPase activities in multi-cycle ischemic preconditioning in rabbit hearts. Eur J Cardiothorac Surg 26 (2004) 981-987
34. + kinetics in preconditioned rat heart. Circ Res 88 (2001) 1176-1182
35. +-ATPase in the inotropic action of digitalis. Pharmacol Rev 29 (1997) 187-220
36. 2+]i in rat cardiac myocytes. Am J Physiol 281 (2001) H1899-H1907
37. 2+ concentrations. J Biol Chem 275 (2000) 27838-27844
38. +-ATPase activity in rat cardiac hypertrophy. J Biol Chem 261 (1986) 185-189
39. Song C., Vondriska T.M., Wang G.W., Klein J.B., Cao X., Zhang J., et al. Molecular conformation dictates signaling module formation: example of PKCepsilon and Src tyrosine kinase. Am J Physiol Heart Circ Physiol 282 (2002) H1166-H1171
40. Ping P., Zhang J., Zheng Y.T., Li R.C., Dawn B., Tang X.L., et al. Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits. Circ Res 85 (1999) 542-550
41. Hattori R., Otani H., Uchiyama T., Imamura H., Cui J., Maulik N., et al. Src tyrosine kinase is the trigger but not the mediator of ischemic preconditioning. Am J Physiol Heart Circ Physiol 281 (2001) H1066-H1074
42. ATP channels. Mol Cell Biochem 242 (2003) 181-187
43. + channel in cardiac function and cardioprotection. Biochim Biophys Acta 1606 (2003) 1-21
44. Bolli R., Becker L., Gross G., Mentzer Jr. R., Balshaw D., and Lathrop D.A. Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ Res 95 (2004) 125-134
45. Kloner R.A., and Rezkalla S.H. Cardiac protection during acute myocardial infarction: where do we stand in 2004?. J Am Coll Cardiol 44 (2004) 276-286
46. Gheorghiade M., Adams Jr. K.F., and Colucci W.S. Digoxin in the management of cardiovascular disorders. Circulation 109 (2004) 2959-2964
47. Young J.B. Whither Withering's legacy? Digoxin's role in our contemporary pharmacopeia for heart failure. J Am Coll Cardiol 46 (2005) 505-507
48. Adams Jr. K.F., Patterson J.H., Gattis W.A., O'Connor C.M., Lee C.R., Schwartz T.A., et al. Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis. J Am Coll Cardiol 46 (2005) 497-504