MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits

Journal of Thoracic and Cardiovascular Surgery

Volumn 126, Issue 5, 2003, Pages 1461-1466

  Takahashi, Goro ^a   Sakurai, Masahiro ^a   Abe, Koji ^b   Itoyama, Yasuto ^a   Tabayashi, Koichi ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; NITRIC OXIDE SYNTHASE; NORPHENAZONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA SURGERY; ARTICLE; BRAIN ISCHEMIA; CELL DAMAGE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENDOTHELIUM CELL; IMMUNOREACTIVITY; ISCHEMIA; LEG; MALE; MOTONEURON; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPINAL CORD LESION;

EID: 0344925065     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(03)00693-7     Document Type: Article

References (30)

1. Symbas PN, Pfaender LM, Drucker MH, Lester JL, Gravaanis MB, Zacharopoulos L. Cross-clamping of the descending aorta: hemodynamic and neurohumoral effects. J Thorac Cardiovasc Surg. 1983;85:300-5.
2. Svensson LG, Rickards E, Coull A, Roger G, Fimmel CJ, Hinder RA. Relationship of spinal cord blood flow to vascular anatomy during thoracic aortic cross-clamping and shunting. J Thorac Cardiovasc Surg. 1986;91:71-8.
3. Pontius RG, Brockman HL, Hardy EG, Cooley DA, Debakay ME. The use of hypothermia on the prevention of paraplasia following temporary aortic occlusion: experimental observation. Surgery. 1954;36:33-8.
4. Grossi EA, Krieger KH, Cunningham JN Jr, Culliford AT, Nathan IM, Spencer FC. Venoarterial bypass: a technique for spinal cord protection. J Thorac Cardiovasc Surg. 1985;89:228-34.
5. Cambria RP, Davidson JK, Zannetti S, L'Italien G, Brewster DC, Gretler JP, et al. Clinical experience with epidural cooling for spinal cord protection during thoracic and thoracoabdominal aneurysm repair. J Vasc Surg. 1997;25:234-43.
6. Kats NM, Blackstone EH, Kirklin JW, Karp RB. Incremental risk factors for spinal cord injury following operation for acute aortic transection. J Thorac Cardiovasc Surg. 1981;81:669-74.
7. Livesay JJ, Cooley DA, Ventemiglia RA, Montero CG, Warrian RK, Brown DM, et al. Surgical experience in descending thoracic aneurysmectomy with and without adjuncts to avoid ischemia. Ann Thorac Surg. 1985;39:37-46.
8. Sakurai M, Aoki M, Abe K, Sadahiro M, Tabayashi K. Selective motor neuron death and heat shock protein induction after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg. 1997;113:159-64.
9. Motoyoshi N, Sakurai M, Hayashi T, Aoki M, Abe K, Itoyama Y, et al. Establishment of a focal cooling model against spinal cord ischemia representing prolonged induction of heat shock protein. J Thorac Cardiovasc Surg. 2001;122:351-7.
10. Watanabe M, Sakurai M, Abe K, Aoki M, Sadahiro M, Tabayashi K, et al. Inductions of Cu/Zn superoxide dismutase- and nitric oxide synthase-like immunoreactivities in rabbit spinal cord after transient ischemia. Brain Res. 1996;732:69-74.
11. Beckman JS, Carson M, Smith CD, Koppenol WH. ALS, SOD and peroxynitrite. Nature. 1993;364:584.
12. Sakurai M, Fukuyama N, Takizawa S, Ake K, Hayashi T, Shinohara Y, et al. Inductions of 3-L-nitrotyrosine in motor neurons after transient spinal cord ischemia in rabbits. J Cereb Blood Flow Metab. 1998;18:1233-38.
13. Hu WH, Li F, Qiang WA, Liu N, Wang GQ, Xiao J, et al. Dual role for nitric oxide in dynorphin spinal neurotoxicity. J Neurotrauma. 1999;16:85-98.
14. Abe K, Yuki S, Kogure K. Strong attenuation of ischemic and post-ischemic brain edema in rats by a novel free radical scavenger. Stroke. 1988;19:480-5.
15. Watanabe T, Watanabe K, Hayashi T. Radical scavenging mechanism of MCI-186. Jpn Pharnmcol Ther. 1997;25:189-97.
16. Sakurai M, Hayashi T, Abe K, Aoki M, Sadahiro M, Tabayashi K. Enhancement of heat shock protein expression after transient ischemia in the preconditioned spinal cord of rabbits. J Vasc Surg. 1998;27:720-5.
17. Zivin JA, Reid JL, Saavedra JM, Kopin IJ. Quantitative localization of biogenic amines in the spinal cord. Brain Res. 1975;99:293-301.
18. Johnson SH, Kraimer JM, Graeber GM. Effect of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits. Stroke. 1993;24:1547-53.
19. Sakurai M, Abe K, Hayashi T, Setoguchi Y, Yaginuma G, Meguro T, et al. Adenovirus-mediated glial cell line-derived neurotrophic factor gene delivery reduces motor neuron injury after transient spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg. 2000;120:1148-57.
20. Flamm ES, Demopoulos HB, Seligman ML, Poser RG, Ransohoff J. Free radicals in cerebral ischemia. Stroke. 1978;9:445-7.
21. Yamamoto Y, Kuwahara T, Watanabe K, Watanabe K. Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one. Redox Rep. 1996;2:333-8.
22. Watanabe T. Protective effect of MCI-186 on cerebral ischemia: possible involvement of free-radical scavenging and antioxidant actions. J Pharmacol Exp Ther. 1994;268:1587-604.
23. Kukreja RC, Kontos HA, Hess ML, Ellis EF. PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ Res. 1986;59:612-9.
24. Chan PH, Fishman RA, Caronna J, Schmidley JW, Priolean G, Lee J. Induction of brain edema following intracerebral injection of arachidonic acid. Ann Neurol. 1983;13:625-32.
25. Sato S, Abe K, Kawagoe J, Aoki M, Kogure K. Isolation of complementary DNAs for heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 genes and the expressions in post-ischemic gerbil brain. Neurol Res. 1992;14:375-80.
26. Murota S, Sato I. Paracrine function of endothelium-derived nitric oxide. Life Sci. 1995;56:1079-87.
27. Aoki M, Ogasawara M, Matsubara Y, Narisawa K, Nakamura S, Itoyama Y, et al. Mild ALS in Japan associated with novel SOD mutation. Nat Genet. 1993;5:323-4.
28. Aoki M, Ogasawara M, Matsubara Y, Narisawa K, Nakamura S, Itoyama Y, et al. Familial amyotrophic lateral sclerosis (ALS) in Japan associated with H46R mutation in Cu/Zn superoxide dismutase gene: a possible new subtype of familial ALS. J Neurol Sci. 1994;126:77-83.
29. Abe K, Pan LH, Watanabe M, Kato T, Itoyama Y. Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis. Neurosci Lett. 1995;199:152-4.
30. Eliasson MJ, Huang Z, Ferrante RJ, Sasamata M, Molliver ME, Snyder SH, et al. Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage. J Neurosci. 1999;19:5910-8.