Kinetic effect of a downstream strand and its 5′-terminal moieties on single nucleotide gap-filling synthesis catalyzed by human DNA polymerase

Journal of Biological Chemistry

Volumn 281, Issue 47, 2006, Pages 35649-35655

  Duym, Wade W ^a   Fiala, Kevin A ^a   Bhatt, Nikunj ^a   Suo, Zucai ^a,b,c  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAP-FILLING DNA SYNTHESIS; MOIETIES; POLYMERASE ACTIVITY;

CATALYST ACTIVITY; DNA; ENZYME KINETICS; ENZYMES; PHOSPHATES; RATE CONSTANTS;

NUCLEIC ACIDS;

5' TERMINAL 2 DEOXYRIBOSE 5 PHOSPHATE; DNA; DNA POLYMERASE; DNA POLYMERASE LAMBDA; PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DNA STRAND; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN BINDING; STEADY STATE; TERMINAL SEQUENCE;

BASE SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DNA POLYMERASE BETA; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IN SITU NICK-END LABELING; KINETICS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; OLIGONUCLEOTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE;

EID: 33846025805     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607479200     Document Type: Article

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