Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis

World Journal of Gastroenterology

Volumn 12, Issue 47, 2006, Pages 7705-7709

  Zhang, Jian Xin ^a   Dang, Sheng Chun ^a   Qu, Jian Guo ^a   Wang, Xue Qing ^a  

^a AFFILIATED HOSPITAL OF JIANGSU UNIVERSITY   (China)

Author keywords

Ligustrazine; Microcirculation; Pancreatitis; Renal injury

Indexed keywords

CREATININE; PENTOBARBITAL; PROSTACYCLIN; RADIOACTIVE MICROSPHERE; TAUROCHOLIC ACID; TETRAMETHYLPYRAZINE; THROMBOXANE A2;

ACUTE HEMORRHAGIC PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; HISTOPATHOLOGY; KIDNEY BLOOD FLOW; KIDNEY FUNCTION TEST; KIDNEY INJURY; MICROANGIOPATHY; NONHUMAN; PANCREAS INJURY; RAT; STATISTICAL SIGNIFICANCE; UREA NITROGEN BLOOD LEVEL;

EID: 33846024338     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i47.7705     Document Type: Article

References (28)

1. Shi C, Andersson R, Zhao X, Wang X. Potential role of reactive oxygen species in pancreatitis-associated multiple organ dysfunction. Pancreatology 2005; 5: 492-500
2. Rau BM, Bothe A, Kron M, Beger HG. Role of early multisystem organ failure as major risk factor for pancreatic infections and death in severe acute pancreatitis. Clin Gastroenterol Hepatol 2006; 4: 1053-1061
3. Du W, Wang H, Zhang SW, Wang BE. Investigation on the relation between systemic inflammatory response syndrome and severity of acute pancreatitis. Zhongguo Weizhongbing Jijiu Yixue 2005; 17: 279-281
4. Zhang JX, Dang SC, Qu JG, Wang XQ Chen GZ. Changes of gastric and intestinal blood flow, serum phospholipase A2 and interleukin-1beta. in rats with acute necrotizing pancreatitis. World J Gastroenterol 2005; 11: 3578-3581
5. Uchikov A, Shopov A, Markova D. Renal complications in severe acute pancreatitis. Khirurgiia (Sofiia) 2003; 59: 9-10
6. Huang J, Moochhala SM, Moore PK, Bhatia M. Flurbiprofen and HCT1026 protect mice against acute pancreatitis-associated lung injury. Shock 2005; 24: 182-187
7. Zhou ZG, Chen YD, Sun W, Chen Z. Pancreatic ndcrocirculatory impairment in experimental acute pancreatitis in rats. World J Gastroenterol 2002; 8: 933-936
8. 2+ in tetramethylpyrazine-induced colonic anion secretion. Cell Biol Int 2006; 30: 547-552
9. Esberg LB, Ren J. The oxygen radical generator pyrogallol impairs cardiomyocyte contractile function via a superoxide and p38 MAP kinase-dependent pathway: protection by anisodamine and tetramethylpyrazine. Cardiovasc Toxicol 2004; 4: 375-384
10. Chen JZ, Dai ZB. The relationship between microcirculation and bacterial translocation in severe acute pancreatitis. Zhonghua Waike Zazhi 1998; 36: 47-49
11. Liu XH, Li QX Effects of ligustrazine on renal cell apoptosis and expression of apoptosis-related proteins in rats with cisplatin-induced renal injury. Zhongguo Yaolixue yu Dulixue Zazhi 2005; 19: 352-356
12. Zhao WC, Zhu JX, Tang N, Gou YL, Rowlands DK, Chung YW, Xing Y, Chan HC. Effect of tetramethylpyrazine on exocrine pancreatic and bile secretion. World J Gastroenterol 2003; 9: 2505-2508
13. Lei WZ, Wei JJ, Shen WL. The relationship between the endotoxemia and damages to multiple organs in experimental necrotic pancreatitis. Zhonghua Shiyan Waike Zazhi 1995; 12: 131-133
14. Dobosz M, Hac S, Mionskowska L, Dymecki D, Dobrowolski S, Wajda Z. Organ microcirculatory disturbances in experimental acute pancreatitis. A role of nitric oxide. Physiol Res 2005; 54: 363-368
15. Yan WW, Zhou ZG, Chen YD, Gao HK. Role of COX-2 in microcirculatory disturbance in experimental pancreatitis. World J Gastroenterol 2004; 10: 2095-2098
16. Obermaier R, Benz S, Von Dobschuetz E, Drognitz O, Schareck W, Jonas L, Messmer K, Hopt UT. Characterization of microcirculatory disturbance in a novel model of pancreatic ischemia-reperfusion using intravital fluorescence-microscopy. Pancreas 2002; 25: 142-148
17. Zhou ZG, Chen YD. Influencing factors of pancreatic microcirculatory impairment in acute panceatitis.World J Gastroenterol 2002; 8: 406-412
18. Johansson M, Carlsson PO, Jansson L. Caerulein-induced pancreatitis and islet blood flow in anesthetized rats. J Surg Res 2003; 113: 13-20
19. Piri M, Alhan E, Kucuktulu U, Ercin C, Deger O, Yucel K, Cicek R. The effects of somatostatin on the ndcroperfusion of the pancreas during acute necrotizing pancreatitis in rats. Hepatogastroenterology 2002; 49: 833-837
20. Foitzik T, Eibl G, Hotz B, Hotz H, Kahrau S, Kasten C, Schneider P, Buhr HJ. Persistent multiple organ microcirculatory disorders in severe acute pancreatitis: experimental findings and clinical implications. Dig Dis Sci 2002; 47: 130-138
21. Chen HM, Sunamura M, Shibuya K, Yamauchi JI, Sakai Y, Fukuyama S, Mikami Y, Takeda K, Matsuno S. Early microcirculatory derangement in mild and severe pancreatitis models in inice. Surg Today 2001; 31: 634-642
22. Uhlmann D, Ludwig S, Geissler F, Tannapfel A, Hauss J, Witzigmann H. Importance of microcirculatory disturbances in the pathogenesis of pancreatitis. Zentralbl Chir 2001; 126: 873-878
23. Tabrizchi R, Pugsley MK. Methods of blood flow measurement in the arterial circulatory system. J Pharmacol Toxicol Methods 2000; 44: 375-384
24. Dobosz M, Wajda Z, Hac S, Mysliwska J, Bryl E, Mionskowska L, Roszkiewicz A, Myshwski A. Nitric oxide, heparin and procaine treatment in experimental ceruleine-induced acute pancreatitis in rats. Arch Immunol Ther Exp (Warsz) 1999; 47: 155-160
25. 2 release in isolated rat heart. Planta Med 1996; 62: 379-381
26. Liao F. Herbs of activating blood circulation to remove blood stasis. Clin Hemorheol Microcirc 2000; 23: 127-131
27. Wang L, Chen S, Xu Z. Effect of hypoxic hypercapnia on expression of endothelin-1 mRNA of pulmonary arterioles in rats. Zhonghua Jiehe He Huxi Zazhi 2000; 23: 591-594
28. Wang WT, Lin LN, Wu JZ, Hu Z, Xie K. Protective effect of ligustrazine and propofol on peri-operational liver ischemiareperfusion injury. Zhongguo Zhongxiyi Jiehe Zazhi 2006; 26: 205-208