Effects of ligustrazine on renal cell apoptosis and expression of apoptosis-related proteins in rats with cisplatin-induced renal injury

Chinese Journal of Pharmacology and Toxicology

Volumn 19, Issue 5, 2005, Pages 352-356

  Liu, Xiao Hua ^a   Li, Qi Xiong ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Apoptosis; cis diamminedichloroplatinum; Ligustrazine; Protein, Bax; Protein, Bcl 2; Toxicity

Indexed keywords

APOPTOSIS RELATED PROTEIN; CISPLATIN; CREATININE; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; KIDNEY CELL; KIDNEY INJURY; NEPHROTOXICITY; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; STATISTICAL SIGNIFICANCE; UREA NITROGEN BLOOD LEVEL; URINALYSIS;

ANIMALIA;

EID: 27644539284     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Goldstein RS, Mayor GH. TTie nephrotoxicity of cisplatin [J]. Life Sci, 1983, 32(7):685-690.
2. Zhang W, Khanna P, Chan LL, Campbell G, Ansari N. Diabetes-induced apoptosis in rat kidney[J]. Biochem Mol Med, 1997, 61(1):58-62.
3. Chen SY, Wang Q, Xiong LZ, Jin WL, Dong H, Liu YH. Effect of sodium ferulate on activation of postsynaptic density-95 after transient cerebral artery occlusion in the rat brain[J]. Acta Fourth Mil Med Univ, 2002, 23(12):1150-1152.
4. Fu H, Li QX. Protective effects and mechanisms of tetramethylpyrazine on accelerated anti-GBM antibody nephritis in rats[J]. Chin Pharmacol Bull, 2004, 20(2):196-199.
5. Wang X, Li QX. Effects of tetramethylpyrazine on proliferation of rat glomerular mesangial cells induced by lipopolysaccharide and levels of intercellular adhesion molecule-1[J]. Chin J Clin Pharm Ther, 2004, 9(4):420-423.
6. Zhang XM, Li JZ, Wei MJ, Hou ZJ, eds. Modern Clinical Biochemical Laboratory Medicine[M]. Bejing:People's Military Medical Publishing House, 2001, 23.
7. Rana A, Sathyanarayana P, Lieberthal W. Role of apoptosis of renal tubular cells in acute renal failure: therapeutic-implications[J]. Apoptosis, 2001, 6(1-2):83-102.
8. Steller H. Mechanisms and genes of cellular suicide[J]. Science, 1995, 267(5203):1445-1449.
9. Sugiyama H, Kashihara N, Makino H, Yamasaki Y, Ota A. Apoptosis in glomenilar sclerosis[J]. Kindney Int, 1996, 49(1):103-111.
10. Lau AH. Apoptosis induced by cisplatin nephrotoxic injury [J]. Kidney Int, 1999, 56(4):1295-1298.
11. Wang X, Chen XX. Study survey and prospect of effect of ligustrazine on cancer cell[J]. China J Chin Mater Med, 2003, 28(4):295-298.