Development of overt proteinuria in the Munich Wistar Frömter rat is suppressed by replacement of chromosome 6 in a consomic rat strain

Journal of the American Society of Nephrology

Volumn 18, Issue 1, 2007, Pages 113-121

  Schulz, Angela ^a   Weiss, Judith ^a   Schlesener, Maria ^a   Hänsch, Jonna ^a   Wehland, Markus ^a   Wendt, Norbert ^a   Kossmehl, Peter ^a   Sietmann, Anika ^b   Grimm, Daniela ^a   Stoll, Monika ^b   Nyengaard, Jens Randel ^c   Kreutz, Reinhold ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Leibniz Institut fur Arterioskleroseforschung   (Germany)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CHOLESTEROL; COLLAGEN TYPE 3; CREATININE; MESSENGER RNA; TRIACYLGLYCEROL; UREA;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 6; CHROMOSOME SUBSTITUTION STRAIN; CONTROLLED STUDY; CREATININE CLEARANCE; GLOMERULOSCLEROSIS; INTROGRESSION; KIDNEY FIBROSIS; KIDNEY INJURY; MALE; NEPHROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; QUANTITATIVE TRAIT LOCUS; RAT; RAT STRAIN; SPONTANEOUSLY HYPERTENSIVE RAT; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL;

EID: 33846011888     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006030206     Document Type: Article

References (38)

1. Hillege HL, Fidler V, Diercks GF, van Gilst WH, de Zeeuw D, van Veldhuisen DJ, Gans RO, Janssen WM, Grobbee DE, de Jong PE: Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation 106: 1777-1782, 2002
2. Toto RD: Proteinuria reduction: Mandatory consideration or option when selecting an antihypertensive agent? Curr Hypertens Rep 7: 374-378, 2005
3. Ritz E: Renal dysfunction as a novel risk factor: Microalbuminuria and cardiovascular risk. Kidney Int Suppl 93: S25-S28, 2005
4. Ruilope LM, Salvetti A, Jamerson K, Hansson L, Warnold I, Wedel H, Zanchetti A: Renal function and intensive lowering of blood pressure in hypertensive participants of the hypertension optimal treatment (HOT) study. J Am Soc Nephrol 12: 218-225, 2001
5. Schulz A, Litfin A, Kossmehl P, Kreutz R: Genetic dissection of increased urinary albumin excretion in the Munich Wistar Frömter rat. J Am Soc Nephrol 13: 2706-2714, 2002
6. Freedman BI, Beck SR, Rich SS, Heiss G, Lewis CE, Turner S, Province MA, Schwander KL, Arnett DK, Mellen BG: A genome-wide scan for urinary albumin excretion in hypertensive families. Hypertension 42: 291-296, 2003
7. Krolewski AS, Poznik GD, Placha G, Canani L, Dunn J, Walker W, Smiles A, Krolewski B, Fogarty DG, Moczulski D, Araki S, Makita Y, Ng DP, Rogus J, Duggirala R, Rich SS, Warram JH: A genome-wide linkage scan for genes controlling variation in urinary albumin excretion in type II diabetes. Kidney Int 69: 129-136, 2006
8. Fogarty DG, Rich SS, Hanna L, Warram JH, Krolewski AS: Urinary albumin excretion in families with type 2 diabetes is heritable and genetically correlated to blood pressure. Kidney Int 57: 250-257, 2000
9. Fogarty DG, Hanna LS, Wantman M, Warram JH, Krolewski AS, Rich SS: Segregation analysis of urinary albumin excretion in families with type 2 diabetes. Diabetes 49: 1057-1063, 2000
10. Fox CS, Yang Q, Guo CY, Cupples LA, Wilson PW, Levy D, Meigs JB: Genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: The Framingham Heart Study. Kidney Int 67: 70-74, 2005
11. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ: Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet 12: 44-51, 1996
12. Shiozawa M, Provoost AP, van Dokkum RP, Majewski RR, Jacob HJ: Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy. J Am Soc Nephrol 11: 2068-2078, 2000
13. Garrett MR, Dene H, Rapp JP: Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. J Am Soc Nephrol 14: 1175-1187, 2003
14. Poyan MA, Siegel AK, Kossmehl P, Schulz A, Plehm R, de Bruijn JA, de HE, Kreutz R: Early onset albuminuria in Dahl rats is a polygenetic trait that is independent from salt loading. Physiol Genomics 14: 209-216, 2003
15. Schulz A, Standke D, Kovacevic L, Mostler M, Kossmehl P, Stoll M, Kreutz R: A major gene locus links early onset albuminuria with renal interstitial fibrosis in the MWF rat with polygenetic albuminuria. J Am Soc Nephrol 14: 3081-3089, 2003
16. Yagil C, Sapojnikov M, Wechsler A, Korol A, Yagil Y: Genetic dissection of proteinuria in the Sabra rat. Physiol Genomics 25: 121-133, 2006
17. Fassi A, Sangalli F, Maffi R, Colombi F, Mohamed EI, Brenner BM, Remuzzi G, Remuzzi A: Progressive glomerular injury in the MWF rat is predicted by inborn nephron deficit. J Am Soc Nephrol 9: 1399-1406, 1998
18. Rothermund L, Nierhaus M, Fialkowski O, Freese F, Ibscher R, Mieschel S, Kossmehl P, Grimm D, Wehland M, Kreutz R: Genetic low nephron number hypertension is associated with dysregulation of the hepatic and renal insulin-like growth factor system during nephrogenesis. J Hypertens 24: 1857-1864, 2006
19. Markel P, Shu P, Ebeling C, Carlson GA, Nagle DL, Smutko JS, Moore KJ: Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet 17: 280-284, 1997
20. Kreutz R, Kovacevic L, Schulz A, Rothermund L, Ketteier M, Paul M: Effect of high NaCl diet on spontaneous hypertension in a genetic rat model with reduced nephron number. J Hypertens 18: 777-782, 2000
21. Remuzzi A, Puntorieri S, Alfano M, Macconi D, Abbate M, Bertani T, Remuzzi G: Pathophysiologic implications of proteinuria in a rat model of progressive glomerular injury. Lab Invest 67: 572-579, 1992
22. Rothermund L, Luckert S, Kossmehl P, Paul M, Kreutz R: Renal endothelin ET(A)/ET(B) receptor imbalance differentiates salt-sensitive from salt-resistant spontaneous hypertension. Hypertension 37: 275-280, 2001
23. de Heer E, Sijpkens YW, Verkade M, den Dulk M, Langers A, Schutrups J, Bruijn JA, van Es LA: Morphometry of interstitial fibrosis. Nephrol Dial Transplant 15[Suppl 6]: 72-73, 2000
24. Nyengaard JR: Stereologic methods and their application in kidney research. J Am Soc Nephrol 10: 1100-1123, 1999
25. Gundersen HJ: Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc 143: 3-45, 1986
26. Fink L, Stahl U, Ermert L, Kummer W, Seeger W, Bohle RM: Rat porphobilinogen deaminase gene: A pseudogene-free internal standard for laser-assisted cell picking. BioTechniques 26: 510-516, 1999
27. Cowley AW Jr, Liang M, Roman RJ, Greene AS, Jacob HJ: Consomic rat model systems for physiological genomics. Acta Physiol Scand 181: 585-592, 2004
28. Remuzzi A, Puntorieri S, Mazzoleni A, Remuzzi G: Sex related differences in glomerular ultrafiltration and proteinuria in Munich-Wistar rats. Kidney Int 34: 481-486, 1988
29. Remuzzi A, Puntorieri S, Battaglia C, Bertani T, Remuzzi G: Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in the rat. J Clin Invest 85: 541-549, 1990
30. Iordache BE, Imberti O, Foglieni C, Remuzzi G, Bertani T, Remuzzi A: Effects of angiotensin-converting enzyme inhibition on glomerular capillary wall ultrastructure in MWF/Ztm rats. J Am Soc Nephrol 5: 1378-1384, 1994
31. Macconi D, Ghilardi M, Bonassi ME, Mohamed EI, Abbate M, Colombi F, Remuzzi G, Remuzzi A: Effect of angiotensin-converting enzyme inhibition on glomerular basement membrane permeability and distribution of zonula occludens-1 in MWF rats. J Am Soc Nephrol 11: 477-489, 2000
32. Remuzzi A, Gagliardini E, Sangalli F, Bonomelli M, Piccinelli M, Benigni A, Remuzzi G: ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease. Kidney Int 69: 1124-1130, 2006
33. Macconi D, Bonomelli M, Benigni A, Plati T, Sangalli F, Longaretti L, Conti S, Kawachi H, Hill P, Remuzzi G, Remuzzi A: Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury. Am J Pathol 168: 42-54, 2006
34. van Goor H, van der Horst ML, Atmosoerodjo J, Joles JA, van TA, Grond J: Renal apolipoproteins in nephrotic rats. Am J Pathol 142: 1804-1812, 1993
35. Hackbarth H, Gartner K, Alt JM, Stolte H: A subline of the Munich Wistar (MW) strain: Response to selection for surface glomeruli. Rat News Lett 7: 1378-1384, 1980
36. Stoll M, Kwitek-Black AE, Cowley AWJ, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ: New target regions for human hypertension via comparative genomics. Genome Res 10: 473-482, 2000
37. Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ: RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J Am Soc Nephrol 16: 852-856, 2005
38. Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR, Evans DJ, Domin J, Flint J, Boyle JJ, Pusey CD, Cook HT: Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature 439: 851-855, 2006