Ciprofloxacin causes cytoskeletal changes and detachment of human and rat chondrocytes in vitro

Archives of Toxicology

Volumn 73, Issue 10-11, 2000, Pages 557-563

  Egerbacher, Monika ^b   Seiberl, Gertrude ^a   Wolfesberger, Birgitt ^b   Walter, Ingrid ^b  

^a KAISER FRANZ JOSEF HOSPITAL   (Austria)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

Chondrocytes; Cytoskeleton; Fluoroquinolones; Integrins; Magnesium

Indexed keywords

ACTIN; CIPROFLOXACIN; COLLAGEN TYPE 2; INTEGRIN; MAGNESIUM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VIMENTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL ADHESION; CELL GROWTH; CELL SHAPE; CHONDROPATHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; HUMAN TISSUE; MAGNESIUM DEFICIENCY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPECIES DIFFERENCE;

ANIMALIA;

EID: 0001406037     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050008     Document Type: Article

References (32)

1. Akiyama SK (1996) Integrins in cell adhesion and signaling. Hum Cell 9: 181-186
2. Albelda SM, Buck CA (1990) Integrins and other cell adhesion molecules. FASEB J 4: 2868-2880
3. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD (1990) Molecular biology of the cell, 2nd edn. Garland Publishing, NY
4. Ball P (1998) The quinolones: history and overview. In: Andriole VT (ed) The quinolones, 2nd edn. Academic Press, San Diego, CA, pp 2-22
5. Bergan T (1998) Pharmacokinetics of the fluoroquinolones. In: Andriole VT (ed) The quinolones, 2nd edn. Academic Press, San Diego, CA, pp 143-182
6. Bretscher A (1991) Microfilament structure and function in the cortical cytoskeleton. Annu Rev Cell Biol 7: 337-374
7. Burkhardt JE (1996) Review of quinolone arthropathy in the dog. Chemotherapie J 5: 14-18
8. Burkhardt JE, Hill MA, Lamar CH, Smith GN, Carlton WW (1993) Effects of difloxacin on the metabolism of glycosaminoglycans and collagen in organ cultures of articular cartilage. Fundam Appl Toxicol 20: 257-263
9. Carlier MF (1991) Actin: protein structure and filament dynamics. J Biol Chem 266: 1-4
10. Chysky V, Hullmann R (1992) How safe is ciprofloxacin in pediatrics? Worldwide clinical experience based on compassionate use. Antimicr Antineopl Chemother 11: 277-287
11. Defilippi P, Gismondi A, Santoni A, Tarone G (1997) Signal transduction by integrins. Landes Biosience, Austin, Texas
12. Dickeson SK, Walsh JJ, Santoro SA (1997) Contributions of the I and EF hand domains to the divalent cation-dependent collagen binding activity of the alpha2betal integrin. J Biol Chem 272: 7661-7668
13. Dürr J, Goodman S, Potocnik A, Von Der Mark H, Von Der Mark K (1993) Localization of beta 1-integrins in human cartilage and their role in chondrocyte adhesion to collagen and fibronectin. Exp Cell Res 207: 235-244
14. Egerbacher M, Wolfesberger B, Walter I, Seiberl G (1999) Integrins mediate the effects of quinolones and magnesium deficiency on cultured rat chondrocytes. Eur J Cell Biol 78: 391-397
15. Förster C, Kociok K, Shakibaei M, Merker HJ, Vormann J, Günther T, Stahlmann R (1996a) Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats. Arch Toxicol 70: 261-270
16. Förster C, Zippel U, Lozo E, Vormann J, Günther T, Merker HJ, Stahlmann R (1996b) Effects of quinolones enjoint cartilage in juvenile rats and other animals. Chemother J 5 [Suppl]: 6-13
17. Förster C, Rücker M, Shakibaei M, Baumann-Wilschke I, Vormann J, Stahlmann R (1998) Effects of fluoroquinolones and magnesium deficiency in murine limb bud cultures. Arch Toxicol 72: 411-419
18. Hayem G, Petit PX, Levacher M, Gaudin C, Kahn MF, Pocidalo JJ (1994) Cytofluorometric analysis of chondrotoxicity of fluoroquinolones antimicrobial agents. Antimicrob Agents Chemother 38: 243-247
19. Hynes RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11-25
20. Kato M, Takada S, Ogawara S, Takayama S (1995) Effect of levofloxacin on glycosaminoglycan and DNA synthesis of cultured rabbit chondrocytes at concentrations inducing cartilage lesions in vivo. Antimicrob Agents Chemother 39: 1979-1983
21. Menschik M, Neumüller J, Steiner CW, Erlacher L, Köller M, Ullrich R, Graninger W, Graninger WB (1997) Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro. Antimicrob Agents Chemother 41: 2562-2565
22. Loeser RF (1993) Integrin-mediated attachment of articular chondrocytes to extracellular matrix proteins. Arthritis Rheum 36: 1103-1108
23. Loeser RF (1994) Modulation of integrin-mediated attachment of chondrocytes to extracellular matrix proteins by cations, retinoic acid, and transforming growth factor beta. Exp Cell Res 211: 17-23
24. Ross D, Riley R (1993) Physicochemical properties of the fluoroquinolone antimicrobials. V. Effect of fluoroquinolone structure and pH on the complexation of various fluoroquinolones with magnesium and calcium ions. Appl Pharmacol 51: 177-187
25. Schaad UB, Salam MA, Aujard Y, Dagan R, Green SDR, Peltola H, Rubio T, Smith AL, Adam D (1995) Use of fluoroquinolones in pediatrics: consensus report of an international society of chemotherapy commission. Pediatr Infect Dis J 14: 1-9
26. Schwabe R, Borner K, Zippel U, Förster C, Baumann-Wilschke I, Stahlmann R (1997) Concentration of sparfloxacin and ofloxacin in plasma and joint cartilage from juvenile rats. Clin Microbiol Inf 3: 85
27. Stahlmann R, Merker HJ, Hinz N, Chahoud I, Webb J, Heger W, Neubert D (1990) Ofloxacin in juvenile non-human primates and rats. Arthropathia and drug plasma concentrations. Arch Toxicol 64: 193-204
28. Stahlmann R, Förster C, Shakibaei M, Vormann J, Günther T, Merker HJ (1995) Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy. Antimicrob Agents Chemother 39: 2013-2018
29. Stahlmann R, Vormann J, Günther T, Förster C, Zippel U, Lozo E, Schwabe R, Kociok K, Shakibaei M, Merker HJ (1997) Effects of quinolones, magnesium deficiency or zinc deficiency on joint cartilage in rats. Magnesium Bull 19: 7-22
30. Tatsumi H, Senda H, Yatera S, Takemoto J, Yamayoshi M, Ohnishi K (1978) Toxicological studies on pipedimic acid V. Effect on diarthrodial joints of experimental animals. J Toxicol Sci 3: 357-367
31. Vormann J, Förster C, Zippel U, Lozo E, Günther T, Merker HJ, Stahlmann R (1997) Effects of magnesium deficiency on magnesium and calcium content in bone and cartilage in developing rats in correlation to chondrotoxicity. Calcif Tissue Int 61: 230-238
32. Walter I, Egerbacher M, Wolfesberger B, Seiberl G (1998) Confocal laser scanning microscopy of chondrocytes in vitro: cytoskeletal changes after quinolone treatment. Scanning 20: 511-515