A new inducible adenoviral expression system that responds to inflammatory stimuli in vivo

Journal of Gene Medicine

Volumn 8, Issue 12, 2006, Pages 1369-1378

  Cai, Gang ^a   Nie, Xiaomeng ^a   Guo, Pin'e ^a   Guan, Zheng ^a   Zhang, Jun ^a   Shen, Qian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Adenoviral vector; Autoimmune diseases; Gene therapy; Inducible promoter

Indexed keywords

ADENOVIRUS VECTOR; CYTOKINE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; LUCIFERASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PLACEBO; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BAGG ALBINO MOUSE; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DOSE RESPONSE; ENZYME ASSAY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY DISEASE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC VECTORS; HEART; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; LUCIFERASES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYOCARDIUM; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; TRANS-ACTIVATORS;

ADENOVIRIDAE;

EID: 33845982899     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.983     Document Type: Article

References (25)

1. Fang IM, Lin CP, Yang CH, et al. Inhibition of experimental autoimmune anterior uveitis by adenovirus-mediated transfer of the interleukin-10 gene. J Ocul Pharmacol Ther 2005; 21: 420-428.
2. Smith R, Tarner IH, Hollenhorst M, et al. Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis. Gene Ther 2003; 10: 1248-1257.
3. Tellez N, Montolio M, Biarnes M, et al. Adenoviral overexpression of interleukin-1 receptor antagonist protein increases beta-cell replication in rat pancreatic islets. Gene Ther 2005; 12: 120-128.
4. Hartung HP. Early treatment and dose optimisation. BENEFIT and BEYOND. J Neurol 2005; 252: (Suppl 3): iii44-iii5O.
5. Imhof MO, Chatellard P, Mermod N. Comparative study and identification of potent eukaryotic transcriptional repressors in gene switch systems. J Biotechnol 2002; 97: 275-285.
6. Varley AW, Geiszler SM, Gaynor RB, et al. A two-component expression system that responds to inflammatory stimuli in vivo. Nat Biotechnol 1997; 15: 1002-1006.
7. Bakker AC, van de Loo FA, Joosten LA, et al. C3-Tat/HIV-regulated intraarticular human interleukin-1 receptor antagonist gene therapy results in efficient inhibition of collagen-induced arthritis superior to cytomegalovirus-regulated expression of the same transgene. Arthritis Rheum 2002; 46: 1661-1670.
8. Miagkov AV, Varley AW, Munford RS, et al. Endogenous regulation of a therapeutic transgene restores homeostasis in arthritic joints. J Clin Invest 2002; 109: 1223-1229.
9. Garden GA, Morrison RS. HIV-dementia, Tat-induced oxidative stress, and antioxidant therapeutic considerations. Brain Res Brain Res Rev 2005; 50: 14-26.
10. van de Loo AA, Arntz OJ, Bakker AC, et al. Role of interleukin 1 in antigen-induced exacerbations of murine arthritis. Am J Pathol 1995; 146: 239-249.
11. Cai G, Zhang J, Liu L, et al. Successful treatment of experimental autoimmune myocarditis by adenovirus-mediated gene transfer of antisense CIITA. J Mol Cell Cardiol 2005; 38: 593-605.
12. Butler M, Ng CY, van Heel DA, et al. Modulation of dendritic cell phenotype and functioning an in vitro model of the intestinal epithelium. Eur J Immunol 2006; 36: 864-874.
13. Abe M, Tanaka Y, Saito K, et al. Regulation of interleukin (IL)-1beta gene transcription induced by IL-1beta in rheumatoid synovial fibroblast-like cells, E11, transformed with simian virus 40 large T antigen. J Rheumatol 1997; 24: 420-429.
14. He TC, Zhou S, da Costa LT, et al. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A 1998;95:2509-2514.
15. Lahiri T, Moore PE, Baraldo S, et al. Effect of IL-1beta. on CRE-dependent gene expression in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2002; 283: L1239-1246.
16. Nikcevich KM, Piskurich JF, Hellendall RP, et al. Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-alpha. J Neuroimmunol 1999; 99: 195-204.
17. Herz J, Gerard RD. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 1993; 90: 2812-2816.
18. Huard J, Lochmuller H, Acsadi G, et al. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Ther 1995;2:107-115.
19. Coulthard MG, Swindle J, Munford RS, et al. Adenovirus-mediated transfer of a gene encoding acyloxyacyl hydrolase (AOAH) into mice increases tissue and plasma AOAH activity. Infect Immunol 1996; 64: 1510-1515.
20. Perry MG, Richards L, Harbuz MS, et al. Sequential synovial fluid sampling suggests plasma and synovial fluid IL-6 vary independently in rheumatoid arthritis. Rheumatology (Oxford) 2006;45:229-230.
21. Cheeran MC, Hu S, Gekker G, et al. Decreased cytomegalovirus expression following proinflammatory cytokine treatment of primary human astrocytes. J Immunol 2000; 164: 926-933.
22. Prosch S, Stein J, Staak K, et al. Inactivation of the very strong HCMV immediate early promoter by DNA CpG methylation in vitro. Biol Chem Hoppe Seyler 1996; 377: 195-201.
23. Curradi M, Izzo A, Badaracco G, et al. Molecular mechanisms of gene silencing mediated by DNA methylation. Mol Cell Biol 2002;22:3157-3173.
24. Razin A. CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J 1998; 17: 4905-4908.
25. Brigham KL, Stecenko AA. Gene therapy in acute critical illness. New Horiz 1995; 3: 321-329.