Intramuscular injection of islet neogenesis-associated protein peptide stimulates pancreatic islet neogenesis in healthy dogs

Pancreas

Volumn 34, Issue 1, 2007, Pages 103-111

  Pittenger, Gary L ^a   Taylor Fishwick, David A ^a   Johns, Robert H ^a   Burcus, Niculina ^a   Kosuri, Srivenkat ^a   Vinik, Aaron I ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

Canine; INGAP; Islet; Neogenesis; Pancreas

Indexed keywords

ISLET NEOGENESIS ASSOCIATED PROTEIN; PROTEIN DERIVATIVE; RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG DISTRIBUTION; DRUG MECHANISM; FEMALE; GENE EXPRESSION; HAMSTER; HISTOLOGY; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS CELL; PANCREAS ISLET; PRIORITY JOURNAL; RNA ANALYSIS;

ANIMALS; ANTIGENS, NEOPLASM; CELL DIVISION; CRICETINAE; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DOGS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; ISLETS OF LANGERHANS; LECTINS, C-TYPE; MALE; MESOCRICETUS; RECOMBINANT FUSION PROTEINS; REGENERATION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 33845982235     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpa.0000240609.56806.43     Document Type: Article

References (34)

1. Brockenbrough JS, Weir GC, Bonner-Weir S. Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes. 1988;37:232-236.
2. Smith F, Rosen K, Villa-Kamoroff L, et al. Enhanced IGF-I gene expression in regenerating rat pancreas is localized to capillaries and proliferating ductules. Diabetes. 1990;39(suppl 1):66A.
3. Yonemura Y, Takashima T, Miwa K, et al. Amelioration of diabetes mellitus in partially depancreatized rats by poly(ADP-ribose) synthetase inhibitors. Evidence of islet B-cell regeneration. Diabetes. 1984;33:401-404.
4. Miyaura C, Chen L, Appel M, et al. Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass. Mol Endocrinol. 1991;5:226-234.
5. Rosenberg L, Brown RA, Duguid WP. A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas. J Surg Res. 1983;35:63-72.
6. Terazono K, Yamamoto H, Takasawa S, et al. A novel gene activated in regenerating islets. J Biol Chem. 1988;263:2111-2114.
7. Watanabe T, Yonekura H, Terazono K, et al. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem. 1990;265:7432-7439.
8. Chakraborty C, Katsumata N, Myal Y, et al. Age-related changes in peptide-23/pancreatitis-associated protein and pancreatic stone protein/reg gene expression in the rat and regulation by growth hormone-releasing hormone. Endocrinology. 1995;136:1843-1849.
9. Graf R, Schiesser M, Reding T, et al. Exocrine meets endocrine: pancreatic stone protein and regenerating protein - two sides of the same coin. J Surg Res. 2005;133:113-120.
10. Rafaeloff R, Pittenger GL, Barlow SW, et al. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest. 1997;99:2100-2109.
11. Pittenger GL, Vinik AI, Rosenberg L. The partial isolation and characterization of ilotropin, a novel islet-specific growth factor. Adv Exp Med Biol. 1992;321:123-130.
12. Rosenberg L, Vinik AI, Pittenger GL, et al. Islet-cell regeneration in the diabetic hamster pancreas with restoration of normoglycaemia can be induced by a local growth factor(s). Diabetologia. 1996;39:256-262.
13. Rafaeloff-Phail R, Schmitt E, Sandusky G, et al. INGAP is a human cytokine expressed only in the presence of islet neogenesis. Diabetes. 1998;47(Suppl 1):A259. (Abstract).
14. Semakula C, Pambuccian S, Gruessner R, et al. Clinical case seminar: hypoglycemia after pancreas transplantation: association with allograft nesidiodysplasia and expression of islet neogenesis-associated peptide. J Clin Endocrinol Metab. 2002;87:3548-3554.
15. Rosenberg L, Lipsett M, Yoon JW, et al. A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice. Ann Surg. 2004;240:875-884.
16. Thompson RJ, Doran JF, Jackson P, et al. PGP 9.5 - a new marker for vertebrate neurons and neuroendocrine cells. Brain Res. 1983;278:224-228.
17. Kennedy WR, Wendelschafer-Crabb G, Johnson T. Quantitation of epidermal nerves in diabetic neuropathy. Neurology. 1996;47:1042-1048.
18. McArthur JC, Stocks EA, Hauer P. Epidermal nerve fiber density: normative reference range and diagnostic efficiency. Arch Neurol. 1998;55:1513-1520.
19. Pittenger GL, Ray M, Burcus NI, et al. Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients. Diabetes Care. 2004;27:1974-1979.
20. Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes. 1995;44:249-256.
21. Topp B, Promislow K, deVries G, et al. A model of beta-cell mass, insulin, and glucose kinetics: pathways to diabetes. J Theor Biol. 2000;206:605-619.
22. Lipsett M, Finegood DT. Beta-cell neogenesis during prolonged hyperglycemia in rats. Diabetes. 2002;51:1834-1841.
23. Tam J, Rosenberg L, Maysinger D. INGAP peptide improves nerve function and enhances regeneration in streptozotocin-induced diabetic C57BL/6 mice. FASEB J. 2004;18:1767-1769.
24. Tam J, Rosenberg L, Maysinger D. Islet-neogenesis-associated protein enhances neurite outgrowth from DRG neurons. Biochem Biophys Res Commun. 2002;291:649-654.
25. Dudek RW, Lawrence IE Jr. Morphologic evidence of interactions between adult ductal epithelium of pancreas and fetal foregut mesenchyme. Diabetes. 1988;37:891-900.
26. Dudek RW, Lawrence IE Jr, Hill RS, et al. Induction of islet cytodifferentiation by fetal mesenchyme in adult pancreatic ductal epithelium. Diabetes. 1991;40:1041-1048.
27. Dor Y, Brown J, Martinez OI, et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004;429:41-46.
28. Bonner-Weir S, Baxter LA, Schuppin GT, et al. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes. 1993;42:1715-1720.
29. DCCT Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.
30. DCCT Research Group. The effect of intensive diabetes therapy on the development and progression of neuropathy. Ann Intern Med. 1995;122:561-568.
31. The DCCT Research Group. Effects of age, duration and treatment of insulin-dependent diabetes mellitus on residual beta-cell function: observations during eligibility testing for the Diabetes Control and Complications Trial (DCCT). J Clin Endocrinol Metab. 1987;65:30-36.
32. Palmer JP, Fleming GA, Greenbaum CJ, et al. C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes. 2004;53:250-264.
33. Ratner RE, Feeley D, Team TSR. Double-blind, placebo-controlled trial of islet neogenesis gene associated protein (INGAP) therapy in subjects with type 1 diabetes mellitus (T1DM). Program: 65th Scientific Sessions of the American Diabetes Association. 2005: Late Breaking Abstracts.
34. Ratner RE, Feeley D, Team TSR. Double-blind, placebo-controlled trial of islet neogenesis gene associated protein (INGAP) therapy in subjects with type 2 diabetes mellitus (T2DM). Program: 65th Scientific Sessions of the American Diabetes Association. 2005: Late-Breaking Abstracts.