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Volumn 2, Issue 1, 2006, Pages 58-63

A physician's guide to azathioprine metabolite testing

Author keywords

6 mercaptopurine; Azathioprine; IBD; Metabolites; Therapy

Indexed keywords

AZATHIOPRINE; DRUG METABOLITE; MERCAPTOPURINE; MESALAZINE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE;

EID: 33845980547     PISSN: 15547914     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (14)

References (39)
  • 1
    • 0035987193 scopus 로고    scopus 로고
    • Review: Metabolism of immunosuppressant drugs
    • Kelly P, Kahan BD. Review: metabolism of immunosuppressant drugs. Curr Drug Metab. 2002;3:275-287.
    • (2002) Curr Drug Metab , vol.3 , pp. 275-287
    • Kelly, P.1    Kahan, B.D.2
  • 2
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyl transferase activity
    • Weinshilboum RN, Sladek SI. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyl transferase activity. Am J Hum Genet. 1980;32:651-662.
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.N.1    Sladek, S.I.2
  • 3
    • 0021148310 scopus 로고
    • 6-thioguanine induced DNA damage as a determinant of cytotoxicity in cultured hamster ovary cells
    • Christie NT, Drake S, Meyn RE. 6-thioguanine induced DNA damage as a determinant of cytotoxicity in cultured hamster ovary cells. Cancer Res. 1986;44:3665-3671.
    • (1986) Cancer Res , vol.44 , pp. 3665-3671
    • Christie, N.T.1    Drake, S.2    Meyn, R.E.3
  • 4
    • 0023002521 scopus 로고
    • Concurrent unilateral chromatid damage and DNA strand breaks in response to 6-thioguanine treatment
    • Fairchild C-R, Maybaum J, Kennedy KA. Concurrent unilateral chromatid damage and DNA strand breaks in response to 6-thioguanine treatment. Biochem Pharmacol. 1986;35:3533-3541.
    • (1986) Biochem Pharmacol , vol.35 , pp. 3533-3541
    • Fairchild, C.-R.1    Maybaum, J.2    Kennedy, K.A.3
  • 5
    • 0026758498 scopus 로고
    • The clinical pharmacology of 6-mercaptopurine in acute lymphoblastic leukemia
    • Lennard L. The clinical pharmacology of 6-mercaptopurine in acute lymphoblastic leukemia. Eur J Clin Pharmacol. 1992;43:329-339.
    • (1992) Eur J Clin Pharmacol , vol.43 , pp. 329-339
    • Lennard, L.1
  • 6
    • 0034050713 scopus 로고    scopus 로고
    • Screening of thiopurine methyl S-transferase mutations by horizontal conformation-sensitive gel electrophoresis
    • Alves S, Prata MJ, Ferreira F, Amorim A. Screening of thiopurine methyl S-transferase mutations by horizontal conformation-sensitive gel electrophoresis. Human Mutat. 2000;15:246-253.
    • (2000) Human Mutat , vol.15 , pp. 246-253
    • Alves, S.1    Prata, M.J.2    Ferreira, F.3    Amorim, A.4
  • 7
    • 0025837127 scopus 로고
    • Altered mercaptopurine metabolism, toxic effects, and dosage requirements in a thiopurine methyltransferase deficient child with acute lymphoblastic leukemia
    • Evans WE, Horner M, Chu YQ, et al. Altered mercaptopurine metabolism, toxic effects, and dosage requirements in a thiopurine methyltransferase deficient child with acute lymphoblastic leukemia. J Pediatr. 1991;119:985-989.
    • (1991) J Pediatr , vol.119 , pp. 985-989
    • Evans, W.E.1    Horner, M.2    Chu, Y.Q.3
  • 8
    • 0027405396 scopus 로고
    • Cellular pharmacology of 6-mercaptopurine in acute lymphoblastic leukemia
    • Bostrom B, Erdman G. Cellular pharmacology of 6-mercaptopurine in acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol 1993;15:80-86.
    • (1993) Am J Pediatr Hematol Oncol , vol.15 , pp. 80-86
    • Bostrom, B.1    Erdman, G.2
  • 9
    • 0020512528 scopus 로고
    • Childhood leukemia: A relationship between intracellular 6-mercaptopurine metabolites and neutropenia
    • Lennard L, Rees CA, Lilleyman JS, et al. Childhood leukemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia. Br J Clin Pharmacol. 1993:16:359-363.
    • (1993) Br J Clin Pharmacol , vol.16 , pp. 359-363
    • Lennard, L.1    Rees, C.A.2    Lilleyman, J.S.3
  • 10
    • 0020534019 scopus 로고
    • Variable bioavailability of oral mercaptopurine: Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered
    • Zimm S, Collins JM, Riccardi R, et al. Variable bioavailability of oral mercaptopurine: is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered. N Engl J Med. 1983;308:1005-1009.
    • (1983) N Engl J Med , vol.308 , pp. 1005-1009
    • Zimm, S.1    Collins, J.M.2    Riccardi, R.3
  • 11
    • 0028930908 scopus 로고    scopus 로고
    • McLeod HL, Relling MV, Liu Q, Pui CH, Evans WE. Polymorphic thiopurine methyl transferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia. Blood. 1995;85:1897-7-1902.
    • McLeod HL, Relling MV, Liu Q, Pui CH, Evans WE. Polymorphic thiopurine methyl transferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia. Blood. 1995;85:1897-7-1902.
  • 12
    • 0000221097 scopus 로고    scopus 로고
    • Crohn's disease
    • Sleisenger MH, Fordtran JS, eds, Philadelphia, Pa: WB Saunders;
    • Kombluth A, Sachar DB, Salomon P. Crohn's disease. In: Sleisenger MH, Fordtran JS, eds. Gastrointestinal Diseases. Philadelphia, Pa: WB Saunders;1998:1708-1734.
    • (1998) Gastrointestinal Diseases , pp. 1708-1734
    • Kombluth, A.1    Sachar, D.B.2    Salomon, P.3
  • 13
    • 0029134702 scopus 로고
    • Azathioprine and 6-mercaptopurine in Crohn's disease: A meta-analysis
    • Pearson DC, May GR, Fick GH, et al. Azathioprine and 6-mercaptopurine in Crohn's disease: a meta-analysis. Ann Intern Med. 1995;122:132-142.
    • (1995) Ann Intern Med , vol.122 , pp. 132-142
    • Pearson, D.C.1    May, G.R.2    Fick, G.H.3
  • 14
    • 0027181038 scopus 로고
    • Azathioprine combined with prednisolone or monotherapy with prednisolone in active Crohn's disease
    • Ewe K, Press AG, Singe CC, et al. Azathioprine combined with prednisolone or monotherapy with prednisolone in active Crohn's disease. Gastroenterology. 1993;105:367-372.
    • (1993) Gastroenterology , vol.105 , pp. 367-372
    • Ewe, K.1    Press, A.G.2    Singe, C.C.3
  • 15
    • 0025818064 scopus 로고
    • Use of azathioprine or 6-mercaptopurine in the treatment of Crohn's disease
    • O'Brien JJ, Bayless TM, Bayless JA. Use of azathioprine or 6-mercaptopurine in the treatment of Crohn's disease. Gastroenterology. 1991;101:39-46.
    • (1991) Gastroenterology , vol.101 , pp. 39-46
    • O'Brien, J.J.1    Bayless, T.M.2    Bayless, J.A.3
  • 16
    • 0027317141 scopus 로고
    • Long-term experience with 6-mercaptopurine in the treatment of Crohn's disease
    • Korelitz BI, Adler DJ, Mendelsohn RA, et al. Long-term experience with 6-mercaptopurine in the treatment of Crohn's disease. Am J Gastroenterol. 1993;88:1198-1205.
    • (1993) Am J Gastroenterol , vol.88 , pp. 1198-1205
    • Korelitz, B.I.1    Adler, D.J.2    Mendelsohn, R.A.3
  • 17
    • 0018888679 scopus 로고
    • Treatment of Crohn's disease with 6-mercaptopurine: A long-term, randomized, double-blind study
    • Present DH, Korelitz BI, Wisch N, et al. Treatment of Crohn's disease with 6-mercaptopurine: a long-term, randomized, double-blind study. N Engl J Med. 1980;302:981-987.
    • (1980) N Engl J Med , vol.302 , pp. 981-987
    • Present, D.H.1    Korelitz, B.I.2    Wisch, N.3
  • 18
    • 0028293868 scopus 로고
    • The role of leukopenia in 6-mercaptopurine- induced remission of refractory Crohn's disease
    • Colonna T, Korelitz BI. The role of leukopenia in 6-mercaptopurine- induced remission of refractory Crohn's disease. Am J Gastroenterol. 1993;89:362-366.
    • (1993) Am J Gastroenterol , vol.89 , pp. 362-366
    • Colonna, T.1    Korelitz, B.I.2
  • 19
    • 0022362197 scopus 로고
    • The effects of 6-mercaptopurine on natural killer cell activities in Crohn's disease
    • Brogan M, Hiserot J, Olicet M. The effects of 6-mercaptopurine on natural killer cell activities in Crohn's disease. J Clin Immunol. 1985;5:204-211.
    • (1985) J Clin Immunol , vol.5 , pp. 204-211
    • Brogan, M.1    Hiserot, J.2    Olicet, M.3
  • 20
    • 0024457688 scopus 로고
    • 6-mercaptopurine in the management of inflammatory bowel disease: Short and long-term toxicity
    • Present DH, Meltzer SJ, Krumholz MP, et al. 6-mercaptopurine in the management of inflammatory bowel disease: short and long-term toxicity. Ann Intern Med. 1995;111:641-649.
    • (1995) Ann Intern Med , vol.111 , pp. 641-649
    • Present, D.H.1    Meltzer, S.J.2    Krumholz, M.P.3
  • 21
    • 0029794073 scopus 로고    scopus 로고
    • 6-mercaptopurine metabolism in Crohn's disease: Correlation with efficacy and toxicity
    • Cuffari C, Theoret Y, Latour S, et al. 6-mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity. Gut. 1996;39:401-406.
    • (1996) Gut , vol.39 , pp. 401-406
    • Cuffari, C.1    Theoret, Y.2    Latour, S.3
  • 22
    • 0034067784 scopus 로고    scopus 로고
    • Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
    • Dubinsky MC, Lamothe S, Yang HY, et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology. 2000;118:705-713.
    • (2000) Gastroenterology , vol.118 , pp. 705-713
    • Dubinsky, M.C.1    Lamothe, S.2    Yang, H.Y.3
  • 23
    • 0035186469 scopus 로고    scopus 로고
    • 6-mercaptopurine metabolite levels in children with inflammatory bowel disease
    • Gupta P, Gokhlae R, Kirschner BS. 6-mercaptopurine metabolite levels in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2001;33:450-454.
    • (2001) J Pediatr Gastroenterol Nutr , vol.33 , pp. 450-454
    • Gupta, P.1    Gokhlae, R.2    Kirschner, B.S.3
  • 24
    • 0035134907 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn's disease
    • Belaiche J, Desager JP, Horsman Y, Louis E. Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn's disease. Scand J Gastroenterol. 2001;36:71-76.
    • (2001) Scand J Gastroenterol , vol.36 , pp. 71-76
    • Belaiche, J.1    Desager, J.P.2    Horsman, Y.3    Louis, E.4
  • 25
    • 0035037706 scopus 로고    scopus 로고
    • Utilization of erythrocyte 6-thioguanine metabolite levels to optimize therapy in IBD
    • Cuffari C, Hunt S, Bayless TM. Utilization of erythrocyte 6-thioguanine metabolite levels to optimize therapy in IBD. Gut. 2001;48:642-646.
    • (2001) Gut , vol.48 , pp. 642-646
    • Cuffari, C.1    Hunt, S.2    Bayless, T.M.3
  • 26
    • 0000086393 scopus 로고    scopus 로고
    • 6-Thioguanine levels versus white blood cell counts in guiding 6-mercaptopruine and azathioprine therapy
    • Achar JP, Stevens T, Brzezinski A, Seidner D, Lashner B. 6-Thioguanine levels versus white blood cell counts in guiding 6-mercaptopruine and azathioprine therapy. Am J Gastroenterol. 2000;95:A272.
    • (2000) Am J Gastroenterol , vol.95
    • Achar, J.P.1    Stevens, T.2    Brzezinski, A.3    Seidner, D.4    Lashner, B.5
  • 27
    • 0034780344 scopus 로고    scopus 로고
    • Leukopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine or balsalazide
    • Lowry PW, Franklin CL, Weaver AL, et al. Leukopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine or balsalazide. Gut. 2001;49:656-664.
    • (2001) Gut , vol.49 , pp. 656-664
    • Lowry, P.W.1    Franklin, C.L.2    Weaver, A.L.3
  • 28
    • 4544294487 scopus 로고    scopus 로고
    • The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease
    • Goldenberg BA, Rawsthorne P, Berstein CN. The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease. Am J Gastroenterol. 2004;99:1744-1748.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1744-1748
    • Goldenberg, B.A.1    Rawsthorne, P.2    Berstein, C.N.3
  • 29
    • 0036202803 scopus 로고    scopus 로고
    • 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease
    • Dubinsky MC, Yang H, Hassard PV, et al. 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology. 2002;122:904-915.
    • (2002) Gastroenterology , vol.122 , pp. 904-915
    • Dubinsky, M.C.1    Yang, H.2    Hassard, P.V.3
  • 30
    • 0033568538 scopus 로고    scopus 로고
    • Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: Relation to thiopurine metabolism
    • Bo J, Schroder H, Kristinsoon J, et al. Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: relation to thiopurine metabolism. Cancer. 1999;86:1080-1086.
    • (1999) Cancer , vol.86 , pp. 1080-1086
    • Bo, J.1    Schroder, H.2    Kristinsoon, J.3
  • 31
    • 0034034158 scopus 로고    scopus 로고
    • Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia
    • McLeod HL, Krynetski EY, Relling MV, Evans WE. Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia. Leukemia. 2000;14:567-572.
    • (2000) Leukemia , vol.14 , pp. 567-572
    • McLeod, H.L.1    Krynetski, E.Y.2    Relling, M.V.3    Evans, W.E.4
  • 32
    • 0032212759 scopus 로고    scopus 로고
    • Thiopurine methyl transferase predicts therapy-limiting severe toxicity from azathioprine
    • Black AJ, McLeod HL, Capell HA. Thiopurine methyl transferase predicts therapy-limiting severe toxicity from azathioprine. Ann Intern Med. 1998;129:716-718.
    • (1998) Ann Intern Med , vol.129 , pp. 716-718
    • Black, A.J.1    McLeod, H.L.2    Capell, H.A.3
  • 33
    • 0028917479 scopus 로고
    • Sulphasalazine inhibition of thio methyl transferase: Possible mechanism of interaction with 6-mercaptopurine
    • Szumlanski C, Weinshilboum RN. Sulphasalazine inhibition of thio methyl transferase: possible mechanism of interaction with 6-mercaptopurine. Br J Clin Pharmacol. 1995;39:456-459.
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 456-459
    • Szumlanski, C.1    Weinshilboum, R.N.2
  • 34
    • 1542671809 scopus 로고    scopus 로고
    • Molecular genotyping predicts complications of 6-mercaptopurine therapy in childhood IBD
    • Proujansky R, Maxwell M, Johnson J, et al. Molecular genotyping predicts complications of 6-mercaptopurine therapy in childhood IBD. Gastroenterology. 1999;116:A800.
    • (1999) Gastroenterology , vol.116
    • Proujansky, R.1    Maxwell, M.2    Johnson, J.3
  • 35
    • 2342420871 scopus 로고    scopus 로고
    • Thiopurine methyl-transferase activity influences clinical response to azathioprine therapy in patients with IBD
    • Cuffari C, Dassoupolus T, Bayless TM. Thiopurine methyl-transferase activity influences clinical response to azathioprine therapy in patients with IBD. Clin Gastroenterol Hepatol. 2004;2:410-417.
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 410-417
    • Cuffari, C.1    Dassoupolus, T.2    Bayless, T.M.3
  • 36
    • 0037214334 scopus 로고    scopus 로고
    • Safe treatment of thiopurine S-transferase deficient Crohn's disease patients with azathioprine
    • Kaskas BA, Louis E, Hinderof U, et al. Safe treatment of thiopurine S-transferase deficient Crohn's disease patients with azathioprine. Gut. 2003;52:140-142.
    • (2003) Gut , vol.52 , pp. 140-142
    • Kaskas, B.A.1    Louis, E.2    Hinderof, U.3
  • 37
    • 0024818659 scopus 로고
    • Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia
    • Lennard L, Lilleyman JS. Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia. J Clin Oncol. 1989;7:1816-1823.
    • (1989) J Clin Oncol , vol.7 , pp. 1816-1823
    • Lennard, L.1    Lilleyman, J.S.2
  • 38
    • 0032874716 scopus 로고    scopus 로고
    • Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease
    • Sandborn WJ, Tremaine WJ, Wolfe DC, et al. Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease. Gastroenterology. 1999;117:527-535.
    • (1999) Gastroenterology , vol.117 , pp. 527-535
    • Sandborn, W.J.1    Tremaine, W.J.2    Wolfe, D.C.3
  • 39
    • 0344124747 scopus 로고    scopus 로고
    • Changes in red cell mean corpuscular volume (MCV) during azathioprine or 6-mercaptopurine therapy for Crohn's disease may indicate optimal dose titration
    • Garza A, Sninsky CA. Changes in red cell mean corpuscular volume (MCV) during azathioprine or 6-mercaptopurine therapy for Crohn's disease may indicate optimal dose titration. Gastroenterology. 2001;120:A3166.
    • (2001) Gastroenterology , vol.120
    • Garza, A.1    Sninsky, C.A.2


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